Adjustment of the ACEF score by the triglyceride glucose index improves the prediction of clinical outcomes in patients undergoing percutaneous coronary intervention.

Background: The ACEF score (age, creatinine, and left ventricular ejection fraction) and the triglyceride-glucose (TyG) index have been identified as robust risk prediction models for adverse outcomes post-percutaneous coronary intervention (PCI) in coronary atherosclerotic heart disease (CHD) patients. This study aimed to assess whether incorporating the TyG index enhances the predictive ability of the ACEF score and enhances risk stratification for CHD patients undergoing PCI.

Methods: This observational cohort study enrolled 1248 patients diagnosed with CHD who underwent PCI at the Third People's Hospital of Chengdu, China, between May 2018 and December 2022.

Legacy effects of precipitation change: Theories, dynamics, and applications.

The intensification of climate-induced precipitation change poses a dual challenge to terrestrial ecosystems: immediate effects on their structure and function, coupled with legacy effects that persist beyond the cessation of precipitation change. Quantifying these legacy effects accurately can greatly assist in assessing the long-term impact of precipitation change. However, their broader understanding is just beginning.

Development and Validation of the Resident Healthcare-Seeking Culture Scale (RHCS) Among Chinese Demographics in the Community Setting.

Objective: This study aimed to develop a measurement scale with good reliability and validity to assess the reasonableness of resident healthcare-seeking culture.

Methods: This investigation utilized a cross-sectional research design, employing a multi-stage random sampling technique to select adult inhabitants aged eighteen and above who possess fundamental literacy abilities. An online survey was conducted from March to April 2021 across 27 provinces in China, encompassing 911 questionnaires for scale development.

Conicity index and sex differences in relation to carotid plaque instability in Chinese community residents: Conicity index and carotid plaque.

Objectives: The conicity index (CI), an anthropometric parameter of visceral obesity, has exhibited a strong correlation with the incidence of atherosclerosis and cardiovascular events. This study aimed to explore the relationship between CI and carotid plaque instability, as well as the potential differences between sexes in this context.

Methods: Our cross-sectional study included a total of 44,248 participants from the China Stroke High-risk Population Screening and Intervention Program (CSHPSIP), all of whom underwent carotid ultrasound for the evaluation of carotid plaque.

Point mutations in functionally diverse genes are associated with increased natural DNA transformation in multidrug resistant Streptococcus pneumoniae.

DNA transformation is key for phenotypic diversity and adaptation of Streptococcus pneumoniae including in the emergence of multidrug resistance (MDR). Under laboratory conditions, DNA transformation is facilitated by the artificial triggering of competence by the competence stimulating peptide (CSP). In ongoing DNA transformation work, we observed that exogenous CSP was dispensable depending on the combination of strains and culture media.

Optimizing acute chest pain diagnosis: Efficacy of 64-channel multi-slice CT with Snap-Shot Freeze technique in Triple-Rule-out CT angiography.

Objective: This study evaluates the efficacy of Snap-Shot Freeze (SSF) technology combined with optimized contrast medium (CM) injection protocols in Triple-Rule-Out (TRO) computed tomography angiography (CTA) using 64-channel multi-slice CT (MSCT) for diagnosing acute chest pain (ACP).

Materials And Methods: A total of 111 patients presenting with ACP were enrolled and divided into two groups: Group 1 (23 patients) underwent TRO CTA using 64-channel MSCT with SSF technology, while the control group (88 patients) which was further divided into three cohorts underwent specific site CTA scans. Quantitative metrics such as CT values, standard deviation (SD), signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) were calculated for pulmonary artery, coronary arteries, and aortic imaging.

A CIA strategy with eminent drug-loading capacities for tumor ferroptosis-gas synergistic therapy.

: A common challenge of drug loading and delivery using magnetic resonance imaging (MRI) contrast agents (CAs) is the tendency of aggregation and precipitation at high drug loading conditions. Herein, we propose a generic strategy of controlled ideal aggregation (CIA) to restrict the tendency. : Fe, β-Lapachone (LAP), brequinar (BQR), or Sorafenib (SOR) was respectively loaded onto Gd poly (acrylic acid) macrochelate (GP), an MRI CA, in the hollow core of nitrite-modified hollow mesoporous organosilica nanoparticles (HMON-SNO).

Effects of CYP2C19 and CYP2C9 polymorphisms on the efficacy and plasma concentration of lacosamide in pediatric patients with epilepsy in China.

Unlabelled: To evaluate the effects of cytochrome P450 family 2 subfamily C member 9 (CYP2C9) and cytochrome P450 family 2 subfamily C member 19 (CYP2C19) polymorphisms on the plasma concentrations, efficacy, and safety of lacosamide (LCM) among pediatric patients with epilepsy. This prospective study was conducted at two institutions. It included 215 pediatric patients with epilepsy who were under LCM.

A "Janus" Zwitterionic Hydrogel Patch for Tissue Repair and Prevention of Post-Operative Adhesions.

Anti-peritoneal adhesions (PA) are very important after abdominal surgery for that PA often leads to other medical problems and imposes a huge financial burden on the national healthcare system. In this work, a "Janus" zwitterionic hydrogel patch where one side can adhere firmly to the tissue, while the other side has anti-fouling properties and has little interaction with the surrounding tissue has been developed. The "Janus" hydrogel patch is prepared by in situ formation of a bonding polymer layer poly(acrylic-co-N-hydroxysuccinimide acrylate) on one side of zwitterionic hydrogel.

Viable but nonculturable state in the zoonotic pathogen induced by low-grade fever temperature and antibiotic treatment.

The zoonotic pathogen is responsible for diverse human diseases, from mild to life-threatening, but it often eludes detection in culture-based assays. This study investigates the potential of to enter a viable but nonculturable (VBNC) state when exposed to human fever temperature or antibiotics, with this state confirmed by successful resuscitation. Viability was assessed using SYBR Green I/PI staining and propidium monoazide-quantitative polymerase chain reaction (PMA-qPCR), while culturability was determined through colony-forming unit (CFU) counting on blood agar plates.

Injectable and Degradable Zwitterionic Cryogels as Cancer Vaccine Platforms to Prevent Cancer Recurrence after Surgery.

Cancer has become a highly prevalent disease and poses serious threats to human health. Conventional cancer treatments still face high risks of recurrence. Training the immune system to recognize and eliminate tumors via external stimulation, such as vaccines, emerges as a promising approach for cancer prevention and treatment.

Physicians and hospital pharmacists' knowledge, attitudes, and practices towards polypharmacy in older patients with chronic diseases.

This web-based cross-sectional study aimed to evaluate the knowledge, attitudes, and practices of physicians and hospital pharmacists towards polypharmacy in older adult patients with chronic diseases in China. This study enrolled 374 physicians and pharmacists (270 females, 92 physicians) in 20 Chinese provinces between December 2022 and March 2023. The knowledge, attitude, and practice scores were 12.

LSD1 Demethylates and Destabilizes Autophagy Protein LC3B in Ovarian Cancer.

Autophagy is a complex cellular process that can either promote or inhibit cancer progression and development, depending on the context and molecular regulation involved. This study investigates how LSD1 regulates autophagy in ovarian cancer by interacting with the autophagy protein LC3B. Utilizing the bioinformatic analysis of TCGA, CPTAC, and GEO datasets, as well as immunohistochemistry in ovarian cancer patients, we explored the expression association between LSD1 and LC3B.

An environment-responsive platform based on acid-resistant metal organic framework for efficient oral insulin delivery.

Oral insulin delivery is considered a revolutionary alternative to daily subcutaneous injections in terms of compliance and convenience. However, significant challenges remain in terms of inactivation in gastrointestinal environment and limited permeation across the intestinal epithelium. Herein, we used acid-resistant metal-organic framework (PCN-222) to load insulin and modified the exterior with sodium dodecyl sulfate (SDS) to achieve efficient oral insulin delivery.

Age at type 2 diabetes diagnosis and the risk of mortality among US population.

To examine the relationship between age at diagnosis of type 2 diabetes (T2DM) with cardiovascular and all-cause mortality in the U.S. population.

Characteristics of the current situation of drug use in elderly patients with chronic diseases in Chongqing: A cross-sectional survey.

Following improved accessibility to medical services, the phenomenon of polypharmacy in elderly patients with comorbidity has been increasing globally. Polypharmacy patients are prone to drug interactions, adverse drug reactions, and even the risk of death etc. Therefore, there is an urgent need to fully understand the current status and characteristics of drug use in elderly patients with chronic diseases, focusing on polypharmacy factors to ensure that medications for elderly patients are effective and safe.

Laser-based approach to measure small nuclear cross sections in plasma.

We demonstrate an approach successfully measuring very small nuclear isomeric excitation cross sections (on the order of 10 to 100 picobarns) via laser-cluster interaction. The interaction between an intense laser pulse and Kr atomic clusters generates a high-temperature and high-density plasma ball in which nuclear excitations are facilitated by inelastic electron scattering. The electron temperature reaches several hundred keV (corresponding to 10[Formula: see text] K), similar to a stellar environment.

Possibility of diagnosing rotator cuff tears in areas with scarce medical resources: can non-standard anteroposterior radiographs accurately predict rotator cuff tears?

Background: Due to the scarcity and high cost of MRI in resource-constrained regions, prompt diagnosis and treatment of rotator cuff tears remain problematic in these areas. Therefore, extensive research has been conducted to predict rotator cuff tears using simple and affordable anteroposterior radiographs. It remains unclear whether non-standard anteroposterior radiographs would have a notable impact on the preciseness of the diagnosis.

SGLT1 inhibition alleviates radiation-induced intestinal damage through promoting mitochondrial homeostasis.

Radiation-induced intestinal injury (RIII) constitutes a challenge in radiotherapy. Ionizing radiation (IR) induces DNA and mitochondrial damage by increasing reactive oxygen species (ROS). Sodium-glucose cotransporter 1 (SGLT1) is abundant in the gastrointestinal tract and the protective effects of inhibited SGLT1 in kidney and cardiovascular disease have been widely reported.