Electrospun microfibers, designed to emulate the extracellular matrix (ECM), play a crucial role in regulating the cellular microenvironment for tissue repair. Understanding their mechanical influence and inherent biological interactions at the ECM interface, however, remains a complex challenge. This study delves into the role of mechanical cues in tissue repair by fabricating Col/PLCL microfibers with varying chemical compositions and alignments that mimic the structure of the ECM.
View Article and Find Full Text PDFUltrasound-stimulated contrast agents have gained significant attention in the field of tumor treatment as drug delivery systems. However, their limited drug-loading efficiency and the issue of bulky, imprecise release have resulted in inadequate drug concentrations at targeted tissues. Herein, we developed a highly efficient approach for doxorubicin (DOX) precise release at tumor site and real-time feedback via an integrated strategy of "programmable ultrasonic imaging guided accurate nanodroplet destruction for drug release" (PND).
View Article and Find Full Text PDFX chromosome inactivation can balance the effects of the two X chromosomes in females, and emerging evidence indicates that numerous genes on the inactivated X chromosome have the potential to evade inactivation. The mechanisms of escape include modification of DNA, RNA, histone, epitope, and various regulatory proteins, as well as the spatial structure of chromatin. The study of X chromosome inactivation escape has paved the way for investigating sex dimorphism in human diseases, particularly autoimmune diseases.
View Article and Find Full Text PDFObjective: To find out if systemic immune-inflammation index (SII) has the potential to determine the clinical efficacy of TNF-α inhibitors in treating rheumatoid arthritis (RA).
Methods: A retrospective analysis was conducted in 154 RA patients who were treated from January 2021 to January 2023. The patients were grouped, based on their treatment response, into ineffective (32 cases) and effective (122 cases) groups.
Developing abundant Earth-element and high-efficient electrocatalysts for hydrogen production is crucial in effectively reducing the cost of green hydrogen production. Herein, a strategy by comprehensively considering the computational chemical indicators for H* adsorption/desorption and dehydrogenation kinetics to evaluate the hydrogen evolution performance of electrocatalysts is proposed. Guided by the proposed strategy, a series of catalysts are constructed through a dual transition metal doping strategy.
View Article and Find Full Text PDFHydrosulfonylation of alkenes with readily available aromatic iodides via a SO-insetion strategy is presented. The combination of non-noble Ni catalysis with (Pr)SiH as the final reductant enables the efficient formation of aryl and heteroaryl sulfinate intermediates, which undergo Michael-type additions to electron-deficient alkenes for initiating the hydrosulfonylation process. Moreover, the superiority of this protocol is demonstrated by broad substrate scope and good functional group compatibility.
View Article and Find Full Text PDFPurpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can cause systemic damage to multiple organs. This study aims to analyze the value and function of in the diagnosis and pathology of SLE by bioinformatics and immune infiltration analysis.
Patients And Methods: GSE49454 and GSE65391 of SLE were obtained from the GEO dataset, and R software was employed to identify DEGs and investigate their functions.
Background: Digit ratio, especially 2D:4D, is hypothesised as a potential biological marker of exposure to intrauterine sex hormones. The aim of this study was to investigate the association between 10 SNPs of sex steroid hormone receptor (SSHR) related genes and 2D:4D.
Subjects And Methods: 814 college students were randomly selected as research participants.
Developing highly active and robust electrocatalysts for the hydrogen/oxygen evolution reaction (HER/OER) is crucial for the large-scale utilization of green hydrogen. In this study, a collaborative interface optimization guided strategy was employed to prepare a metal-organic framework (MOF) derived heterostructure electrocatalyst (MXene@RuCo NPs). The obtained electrocatalyst requires overpotentials of only 20 mV for the HER and 253 mV for the OER to deliver a current density of 10 mA/cm in alkaline media, respectively, and it also exhibits great performance at high current density.
View Article and Find Full Text PDFThe development of Sn-based materials with electrochemically inactive matrices is a novel strategy to alleviate the volume expansion and giant structure strain/stress during the sodiation/desodiation process. In this work, a freestanding membrane based on the unique bean pod-like host composed by nitrogen-doped carbon fibers and hollow carbon spheres (HCSs) encapsulated with SnCo nanoparticles is synthesized by electrospinning (B-SnCo/NCFs). In this unique bean pod-like structure, Sn acts as a host for Na storage, while the Co plays the important role of an electrochemically inactive matrix that can not only buffer the volume variations but also inhibit aggregation and particle growth of the Sn phase during the electrochemical Na-Sn alloying process.
View Article and Find Full Text PDFBackground: Enterococcus faecalis (E. faecalis) is the most frequently isolated bacteria from teeth with root canal treatment failure. This study aims to evaluate the disinfection effect of ultrasonic-mediated cold plasma-loaded microbubbles (PMBs) on 7d E.
View Article and Find Full Text PDFDysregulation of the immune system is a cardinal feature of opioid addiction. Here, we characterize the landscape of peripheral immune cells from patients with opioid use disorder and from healthy controls. Opioid-associated blood exhibited an abnormal distribution of immune cells characterized by a significant expansion of fragile-like regulatory T cells (Tregs), which was positively correlated with the withdrawal score.
View Article and Find Full Text PDFJ Coll Physicians Surg Pak
December 2022
Objective: To compare thoracic drainage tube placement on clinical outcomes and serum CRP, IL-6, cortisol in patients undergoing thoracoscopic partial pneumonectomy.
Study Design: Analytical study.
Place And Duration Of Study: Yulin Second Hospital, China, between January 2017 and January 2022.
ACS Appl Mater Interfaces
November 2022
As one of the most valuable endogenous gas signaling molecules, carbon monoxide (CO) has been demonstrated in numerous studies to show excellent promise in the treatment of diseases, such as cancer. However, for many years, the inherent high affinity of CO for hemoglobin severely impeded the clinical transformation of CO-based treatments. Therefore, the controlled delivery of CO to target tissues has become a common challenge.
View Article and Find Full Text PDFThe iron and steel industry is a major CO emitter and an important subject for the implementation of carbon emission reduction goals and tasks. Due to the complex ore composition and low iron grade, vanadium-bearing titanomagnetite smelting in a blast furnace consumes more coke and emits more carbon than in an ordinary blast furnace. Injecting hydrogen-rich gas into blast furnace can not only partially replace coke, but also reduce the carbon emission.
View Article and Find Full Text PDFTwo-dimensional (2D) nanomaterials have attracted much attention for lubrication enhancement of grease. It is difficult to disperse nanosheets in viscous grease and the lubrication performances of grease under harsh conditions urgently need to be improved. In this study, the 2D talc nanosheets are modified by a silane coupling agent with the assistance of high-energy ball milling, which can stably disperse in grease.
View Article and Find Full Text PDFBimetallic SbSn alloy stands out among the anode materials for sodium-ion batteries (SIBs) because of its high theoretical specific capacity (752 mAh g ) and good electrical conductivity. However, the major challenge is the large volume change during cycling processes, bringing about rapid capacity decay. Herein, to cope with this issue, through electrostatic spinning and high temperature calcination reduction, the unique bean pod-like free-standing membrane is designed initially, filling SbSn dots into integrated carbon matrix including hollow carbon spheres and nitrogen-doped carbon fibers (B-SbSn/NCFs).
View Article and Find Full Text PDFConventional methods used to control bacterial biofilm infection in root canals have poor efficacy, causing repeated and chronic infections, which pose a great challenge to clinical treatment. Microbubbles, due to their small size and ultrasound (US)-enhanced cavitation effects, have attracted considerable clinical attention. They possess the potential for therapeutic application in restricted spaces.
View Article and Find Full Text PDFClin Exp Rheumatol
January 2023
Objectives: We screened the type I interferon signal pathway factor involved in the pathogenesis of systemic lupus erythematosus (SLE) by whole-genome sequencing in SLE patients and initially analyse their potential functions.
Methods: Use high-throughput sequencing technology to sequence mRNAs on peripheral blood mononuclear cells from SLE patients and healthy controls,and screen out differentially expressed genes related to the type I interferon (IFN) pathway. Quantitative reverse transcription PCR (RT-qPCR) was utilised to verify the expression of the IFI44L gene in SLE patients and healthy controls, and the correlation between its expression level and clinical test indicators of SLE patients were analysed.
In this work, a two-dimensional porous structure of a V-doped NiO film with excellent electrochromic properties on an ITO substrate was synthesized by a hydrothermal method. The influence of V ions on the NiO film was explored by adjusting the amount of V doping, including refining the crystal grains, increasing the specific surface area of the film, and accelerating the diffusion rate of OH in the film. Compared with the undoped NiO film, a 3 atom % V-doped NiO film comes out with superior electrochromic properties with large optical transmittance modulation (81.
View Article and Find Full Text PDFFor the assembly of electrochromic devices (ECDs) with generally multilayer structures, supportive components usually are needed to be incorporated with EC materials. Herein, we reviewed several impressive methods to design and fabricate ECDs with high performance and versatility based on recent frontier research. The first part of the review is centered on the desirability and strengthening mechanism of nanostructured inorganic EC materials.
View Article and Find Full Text PDFColorectal cancer (CRC) is a major killer. Dysregulation of IL-37 and IL-38, both anti-inflammatory cytokines, is observed in auto-immune diseases. The precise regulatory mechanisms of IL-37/IL-38 during the development of CRC remains unclear, but chronic intestinal inflammation is involved in the carcinogenesis of CRC.
View Article and Find Full Text PDFBiomedical imaging technology (like digital subtraction angiography (DSA)) based on contrast agents has been widely employed in the diagnosis of vascular-related diseases. While the DSA achieves the high-resolution observation of specified vessels and their downstream perfusion at the cost of invasive, radioactive operation and hepatorenal toxicity. To address those problems, this study develops arterial labeling ultrasound (US) subtraction angiography (ALUSA) based on a new perfluorobutane (PFB) nanodroplets with a lower vaporization threshold through spontaneous nucleation.
View Article and Find Full Text PDFSilicon, as an anode candidate with great promise for next-generation lithium-ion batteries (LIBs), has drawn massive attention. However, the deficiencyies of tremendous volume change and intrinsic low electron/ion conductivity will hinder its further development. To cope with these bottlenecks, from the aspect of dimension design concept, the diverse dimensionality of microaggregates derived from cogenetic Si/C nano-building blocks was explored rather than the conventional strategies such as morphology control, structure design, and composition adjustment of Si/C.
View Article and Find Full Text PDF