Synergistic catalytic degradation of benzene and toluene on spinel MMnO (MCo, Ni, Cu) catalysts.

Owing to the complexity of multicomponent gases, developing multifunctional catalysts for synergistic removal of benzene and toluene remains challenging. The spinel MMnO (MCo, Ni, or Cu) catalysts were successfully synthesized via the sol-gel method and tested for their catalytic performance for simultaneous degradation of benzene and toluene. The CuMnO sample exhibited the best catalytic performance, the conversion of benzene reached 100 % at 350 °C, and toluene conversion reached 100 % at 250 °C.

Deficiency of psmb6 suppresses proteasome activity and promotes apoptosis in larval zebrafish brain.

In humans, the abnormal accumulation of proteins is strongly correlated with neurodegenerative diseases. PSMB6 is a member of the proteasome family and encodes the 20S subunit beta 6 which performs caspase-like proteasome activity. However, the biological roles of PSMB6 in neurodevelopment are poorly defined.

An in-depth study of the growth inhibition of Vibrio parahaemolyticus by Surfactin and its effects on cell membranes, ROS levels and gene transcription.

Acute hepatopancreatic necrosis disease (AHPND) caused by Vibrio parahaemolyticus (Vp) poses a significant challenge to the shrimp farming industry. Although lipopeptides produced by Bacillus subtilis have been shown to exert strong inhibitory effects against Vibrio parahaemolyticus, the underlying mechanisms remain largely unexplored. This study reveals that the lipopeptide surfactin, produced by Bacillus subtilis, significantly inhibits the Vp strain JSHY-1669 through multiple mechanisms.

Argon improves microglia-mediated hippocampal neuronal hyperexcitability to alleviate anxiety-like behaviors in mice.

The role of inflammation in psychiatric disorders, such as anxiety, has gained increasing attention, with the hippocampus being identified as a key region involved in emotional regulation. Argon has been reported to alleviate the symptoms of psychiatric disorders; however, its underlying mechanism remains unclear. In this study, we found that argon significantly suppressed lipopolysaccharide (LPS)-induced anxiety-like behaviors and attenuated hippocampal neuronal hyperexcitability in mice.

Post-pericardiectomy ECMO for constrictive pericarditis: a case series and literature review.

Background: Pericardiectomy is the curative treatment for constrictive pericarditis, yet postoperative low cardiac output syndrome (LCOS) may occur. The application of venoarterial extracorporeal membrane oxygenation (VA-ECMO) in post-pericardiectomy refractory LCOS has limited case reports, and its effectiveness and safety remain unclear. This study aims to provide evidence for the effectiveness of ECMO in treating post-pericardiectomy refractory LCOS.

Cleaving PINK1 or PGAM5? Involvement of PARL in Methamphetamine-Induced Excessive Mitophagy and Neuronal Necroptosis.

Background: Methamphetamine (Meth) is a potent psychoactive stimulant that triggers complex neurotoxicity characterized by autophagy-associated neuronal death. However, the potential mechanisms remain poorly understood. This study aimed to decipher the Meth-induced neuronal necroptosis involving mitochondrial defect-initiated excessive mitophagy caused by aberrant presenilin-associated rhomboid-like (PARL) cleavage of PTEN-induced kinase 1 (PINK1) and phosphoglycerate mutase family member 5 (PGAM5).

Discovery and biological evaluation of hederagenin derivatives as non-substrate inhibitors of P-glycoprotein-mediated multidrug resistance.

Multidrug Resistance (MDR) is an essential cause of failure of tumor chemotherapy, and P-glycoprotein (P-gp) overexpression is one of the major causes of MDR in tumor cells. Hederagenin (HRG) derivatives showed significant inhibitory effects in P-gp-mediated tumor MDR. Herein, we designed and synthesized 30 HRG derivatives and evaluated these compounds' tumor MDR reversal ability.

Copy Number Variations of the Gene and Their Associations with Growth Traits in Three Chinese Sheep Breeds.

Background/objectives: Copy number variations (CNVs) are a significant source of genetic variation and have been shown to influence growth traits in livestock. This study aimed to validate previous CNV candidates within the gene (XM_015093798.1) and identify novel CNV markers for molecular breeding in sheep.

Recent Advances, Challenges, and Functional Applications of Natural Phenolic Compounds in the Meat Products Industry.

Natural phenolic compounds (NPCs) have been proven to effectively extend the storage time of meat products in recent years. To promote the discovery of more NPCs and their applications, this review examines recent progress in the classification, antioxidant, and antibacterial mechanisms of NPCs used in meat products. These compounds are found in both edible and inedible parts of plants, including fruits, vegetables, and trees.

The application of endoscopic debridement combined with metagenomic next-generation sequencing technology in primary spinal infections: a retrospective study.

Purpose: Spinal endoscopy is a novel minimally invasive spinal surgery technique used in recent years to treat various degenerative spinal diseases. Metagenomic next-generation sequencing (mNGS) is a new method for identifying infectious microorganisms in infectious diseases. We aim to evaluate the application effect of combining spinal endoscopy with mNGS in diagnosing and treating spinal infections.

Bone marrow mesenchymal stem cells alleviate neurological dysfunction by reducing autophagy damage via downregulation of SYNPO2 in neonatal hypoxic-ischemic encephalopathy rats.

Neonatal hypoxic-ischemic encephalopathy (HIE) is worsened by autophagy-induced neuronal damage, with SYNPO2 playing a key role in this process. This study investigates the involvement of SYNPO2 in neuronal autophagy and explores the potential of bone marrow mesenchymal stem cells (BMSCs) to alleviate HIE-induced dysfunction by inhibiting SYNPO2-mediated autophagy. Using in vitro and in vivo neonatal HIE models, we observed an upregulation of SYNPO2 expression, accompanied by increased neuronal injury and aggregation of autophagy-related proteins.

Indole derivatives ameliorated the methamphetamine-induced depression and anxiety via aryl hydrocarbon receptor along "microbiota-brain" axis.

In addition to the high neurotoxicity, depression, and anxiety are the most prominent characteristics of methamphetamine (Meth) withdrawal. Studies to date on the issue of Meth-associated depression and anxiety are focused on the brain, however, whether peripheral homeostasis, especially the "microbiota-gut" axis participates in these adverse outcomes, remains poorly understood. In the current study, with the fecal microbiota transplantation (FMT) assay, the mice received microbiota from Meth withdrawal mice displayed marked depression and anxiety behaviors.

Investigation of anti-inflammatory effect of essential oil extracted from Achillea alpina L. through multi-omics analysis in zebrafish tail fin amputation model.

Ethnopharmacological Relevance: Achillea alpina L. is a traditional herbal medicine with a long history, which is often used to detoxify and relieve pain. Achillea alpina L.

Corrigendum: Metabolic changes before and after weaning in Dezhou donkey foals in relation to gut microbiota.

[This corrects the article DOI: 10.3389/fmicb.2023.

Current status and influencing factors of sleep-related worry among nurses in the department of anesthesiology: a cross-sectional study.

Background: Anesthesiology, as the core field of the treatment of critically ill patients, carries great work risks and pressure. Due to the uniqueness of their working environment and nature, medical staff have become a high incidence group of sleep-related worry and sleep disorders.

Objective: To investigate the sleep status of anesthesia nurses and analyze related influencing factors, so as to provide a reference for formulating targeted intervention measures.

Reprogrammed Plant Metabolism During Viral Infections: Mechanisms, Pathways and Implications.

Plant viruses pose a significant threat to global agriculture, leading to substantial crop losses that jeopardise food security and disrupt ecosystem stability. These viral infections often reprogramme plant metabolism, compromising key pathways critical for growth and defence. For instance, infections by cucumber mosaic virus alter amino acid and secondary metabolite biosynthesis, including flavonoid and phenylpropanoid pathways, thereby weakening plant defences.

Modulated regulation of the stress-feeding-growth neuroendocrine cascade in Chinese sea bass (Lateolabrax maculatus) under temperature and salinity changes.

Temperature and salinity are among the most important factors affecting food-intake, metabolism, and growth of aquatic animals through their neuroendocrine systems. However, how the regulation of feeding, metabolism and growth are integrated under thermo-saline interaction is still unclear. In this study, modulated transcriptomic responses to temperature and salinity changes were investigated in Chinese sea bass (Lateolabrax maculatus), the economically important fish in East Asia that can adapt to diverse thermo-saline environments.

Deep learning enabled open-set bacteria recognition using surface-enhanced Raman spectroscopy.

Accurate bacterial identification is vital in medical and healthcare settings. Traditional methods, though reliable, are often time-consuming, underscoring the need for faster, more efficient alternatives. Deep learning-assisted Surface-enhanced Raman spectroscopy (SERS) offers a rapid and sensitive method, demonstrating high accuracy in bacterial identification.

Hemodynamic and Pharmacokinetic Interactions of TPN171 with Alcohol in Healthy Male Subjects.

This study aimed to evaluate the effects of the concomitant administration of TPN171 and alcohol on hemodynamic and pharmacokinetic characteristics in healthy Chinese male subjects. Fifteen eligible subjects were randomly assigned to one of three sequences, each comprising three treatments: Treatment A (placebo +0.5 g/kg alcohol), Treatment B (TPN171 + 0.

Clinical validity of dried blood spot assay for the measurement of functional C1 inhibitor in angioedema due to C1 inhibitor deficiency.

Background: Functional C1 inhibitor (fC1INH) is a key biomarker for the diagnosis of hereditary angioedema due to C1 inhibitor (C1INH) deficiency. A novel fC1INH assay from dried blood spot (DBS) reduces practical fC1INH testing limitations versus conventional fC1INH assays, but its sensitivity and specificity have not yet been characterized.

Objective: We sought to assess the sensitivity and specificity of fC1INH DBS assay and conventional fC1INH ELISA and chromogenic assay.

Effects of pits of different ages on ethyl acetate and its metabolism-related microorganisms during strong-flavor Baijiu fermentation.

The esters are the most important flavor components in Baijiu as their species and content decide the style of Baijiu. During the formation of esters, pits play important roles. In this study, the main esters and their related microorganisms in different years of pits (5, 35 and 100 years) of strong-flavor Baijiu were comprehensively researched by headspace solid-phase microextraction gas chromatography mass spectrometry (HS-SPME-GC-MS) and amplicon sequencing.

Molecular insight into reproductive toxicity and transgenerational effects of Cadmium exposure on Drosophila melanogaster.

Cadmium (Cd), a widespread and serious environmental pollutant, has recently garnered increasing scientific scrutiny due to its profound adverse effects. Although the evidence for Cd-induced reproductive toxicity is well established, it remains elusive on the intricate dose-response relationship and underlying molecular mechanisms, especially for transgenerational toxicity in animals. Here, we employed fruit fly (Drosophila melanogaster) as a model organism to examine the reproductive performance across five generations by parental exposure to varying concentrations of Cd (5, 50, and 500 μM).

Weighted EHR-based prevalence estimates for hypertension at the state and local levels in Louisiana.

Background: Modernization of public health data systems is a national priority. Improved chronic disease surveillance can provide more timely, accurate, and local measures to inform public health policy and intervention. Although electronic health record (EHR) data have great potential for surveillance, population coverage is non-random, which may result in biased estimates.

Baculoviruses manipulate host lipid metabolism via adipokinetic hormone signaling to induce climbing behavior.

Baculoviruses can induce climbing behavior in caterpillar hosts, which provides an excellent model for studying parasite manipulation of host behavior. Herein, we found that Helicoverpa armigera single nucleopolyhedrovirus (HearNPV) promoted lipid metabolism of infected H. armigera larvae, and changes in lipid metabolism can affect climbing behavior.