Publications by authors named "Jibu Thomas"

The requirement for accurate treatments for skin diseases and wounds, generated a rising interest towards multifunctional polymer composites, that are capable of mimicking the natural compositions in human body. Also, electroactive composite films disseminate endogenous electrical stimulations that encourage cell migration and its proliferation at wound site, proposing greater opportunities in upgrading the conventional wound patches. In this work, the composite film made of graphene oxide, AgO, PVA and chitosan were developed for wound healing applications, by the solution casting method.

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Scientific research targeted at enhancing scaffold qualities has increased significantly during the last few decades. This emphasis frequently centres on adding different functions to scaffolds in order to increase their usefulness as instruments in the field of regenerative medicine. This study aims to investigate the efficacy of a multifunctional sustainable polymer scaffold, specifically Polycaprolactone (PCL) embedded with hydroxyapatite co-doped with vanadium and strontium (HVS), for bone tissue engineering applications.

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Silica nanoparticles, also known as SiO nanoparticles, have wider applications in biomedical, building, water treatment, agriculture, and food industries. It is used as an anticaking agent in the food industry, used to remove heavy metals from water, and used in cement-based materials. SiO nanoparticles synthesized by physical and chemical methods require high energy and use of toxic chemicals which is quite expensive, have a greater impact causing health-related issues, and have environmental side effects.

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HLA typing serves as a standard practice in hematopoietic stem cell transplantation to ensure compatibility between donors and recipients, preventing the occurrence of allograft rejection and graft-versus-host disease. Conventional laboratory methods that have been widely employed in the past few years, including sequence-specific primer PCR and sequencing-based typing (SBT), currently face the risk of becoming obsolete. This risk stems not only from the extensive diversity within HLA genes but also from the rapid advancement of next-generation sequencing and third-generation sequencing technologies.

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Introduction: The primary goal of quality improvement is to enhance patient outcomes, particularly in the emergency department (ED). Timely and effective care is crucial in these situations. By comprehending the challenges, evaluating current performance and implementing quality improvement projects, areas in need of enhancement can be pinpointed and addressed, resulting in better outcomes.

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Practically, high-yield conversion of biomass into value-added products at low cost is a primary goal for any lignocellulosic refinery. In the industrial context, the limitation in the practical adaptation of the conventional techniques practically involves multiple reactors for the conversion of biomass to bioproducts. Therefore, the present manuscript critically reviewed the advancements in one-pot reaction systems with a major focus on the scientific production of value-added products from lignocellulosic biomass.

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Objectives: Palliative care (PC) referral in serious and critical COVID-19 improves decision-making, health resource utilisation, end-of-life symptom management and family support. In this study, we explored developing a systematic decision-making matrix for PC referral in COVID-19 and audited its outcomes.

Materials And Methods: A team of interdisciplinary experts developed a hospital COVID-19 PC plan.

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One nucleotide substitution in codon 179 of HLA-DRB4*01:03:01:01 results in a novel allele HLA-DRB4*01:152.

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One nucleotide substitution in codon 85 of HLA-DPA1*01:03:01:04 results in a novel allele HLA-DPA1*01:03:34.

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Tea is by and large a highly penetrated product in south India. Hence the adulteration risk in tea dust gets hiked in the markets. We constructed a standard database using plant plastid markers () and nuclear () locus from prominent south Indian tea clones representing Assam, China, and Cambod varieties.

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An effective antitumor drug like cisplatin has toxic effects leading to kidney injury. The authors investigated the nephroprotective action of leaf buds (CSB) and its flowers (CSF), both individually and in combined therapy against cisplatin-induced renal injury. Renal functional tests, oxidant, anti-oxidant and histopathology of kidney tissues are assessed.

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A structured-segregated dynamic model for biomass growth, sucrose utilization and flavonoid production in Ocimum tenuiflorum suspension culture is proposed, considering a dynamic heterogeneous population of viable active, viable nonactive and dead cell. The sucrose hydrolysis (into glucose and fructose), substrate uptake by biomass and intracellular flavonoid production are modelled using Contois kinetics, a competitive double-substrate Monod, and Luedeking-Piret model, respectively. The conversion of active to viable-nonactive biomass has been formulated as a function of the total substrate and biomass concentrations.

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Oleaginous microalgae with high biomass productivity, lipid content, and lipid productivity are desirable for sustainable biofuel production. Rapid and accurate quantification of lipid content facilitates the identification of promising microalgae candidates. In the present study, 23 freshwater microalgae species from river Noyyal were isolated and identified based on their morphological and molecular (18S rRNA) features and recorded as Karunya Algae Culture Collection (KACC).

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The present investigation embarks on understanding the relationship between microalgal species assemblages and their associated physico-chemical parameter dynamics of the catchment region of river Noyyal. Totally, 142 microalgae cultures belonging to 10 different families were isolated from five different sites during four seasons and relative percentage distribution showed that Scenedesmaceae (36.6%) and site S1 (26.

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Mulberry (M. alba L.) has prominent use in traditional Chinese medicine since ancient times but its therapeutic properties have not been sufficiently explored in India.

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The approach of combining the microalgae cultivation with wastewater provides a cost-effective and eco-friendly perspective in the production of microalgae-based bio-products. In the present investigation, microalgae Scenedesmus rubescens KACC 2 isolated from catchment region of River Noyyal was found to be efficient in removing nitrogen, phosphorus, and heavy metals from industrial and domestic effluents, which was optimized through central composite design matrix for higher biomass generation. Nutrient requirements for the growth were optimized and evaluated using Plackett-Burman design to check the effect of variables.

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Research on bioremediation of polycyclic aromatic hydrocarbons (PAHs) has established that several remediating microbial species are capable of degrading only low molecular weight (LMW)-PAHs, whereas high molecular weight (HMW)-PAHs are hardly degradable. In the present study, the efficiency of degradation of both LMW and HMW-PAHs by cytochrome P450 monooxygenase (CYP) of microalgae was studied. CYP have a key role in the detoxification of xenobiotics.

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Economically viable production facilities for microalgae depend on the optimization of growth parameters with regard to nutrient requirements. Using microalgae to treat industrial effluents containing heavy metals presents an alternative to the current practice of using physical and chemical methods. Present work focuses on the statistical optimization of growth of Chlorococcum humicola to ascertain the maximum production of biomass.

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The heterogeneous Indian tea germplasm includes 'China', 'Assam', 'Cambod', and their hybrids which were evaluated using biochemical markers viz., total catechin and their fractions, for varietal identification and characterization. Principal component analysis (PCA) of biochemical characters showed that the total catechin and trihydroxylated catechin has higher eigenvalues.

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A study has been undertaken to characterize 15 field grown somaclonal variants derived from cotyledonary tissues of UPASI-10 using morphological, physiological and biochemical characters. Although variants were derived from UPASI-10, a very few variants possessed unique "Chinery" characters while others exhibited "Assam" characters. However, no variant showed identical morphological characters aligning with the parent.

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Adoption of inter simple sequence repeats (ISSR) technique to analyze the genetic variability of somatic embryo derived tea plants was evaluated. Morphological characterisation of the field grown plants revealed no identical character aligning with the parent, UPASI-10. Out of 40 primers, 15 exhibited concurrent polymorphism were selected for the study.

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