Publications by authors named "Jibrin Paul"
Background: Through whole-exome sequencing of 60 formalin-fixed paraffin-embedded Nigerian (NGRn) benign prostatic hyperplasia (BPH) samples, we identified germline and somatic alterations in apoptotic pathways impacting BPH development and progression. Prostate enlargement is a common occurrence in male aging; however, this enlargement can lead to lower urinary tract symptoms that negatively impact quality of life. This impact is disproportionately present in men of African ancestry.
View Article and Find Full Text PDFUnlabelled: In this study, we used whole-exome sequencing of a cohort of 45 advanced-stage, treatment-naïve Nigerian (NG) primary prostate cancer tumors and 11 unmatched nontumor tissues to compare genomic mutations with African American (AA) and European American (EA) The Cancer Genome Atlas (TCGA) prostate cancer. NG samples were collected from six sites in central and southwest Nigeria. After whole-exome sequencing, samples were processed using GATK best practices.
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- Ovarian cancer is more prevalent among Black women in West Africa compared to those in North America, and survival rates are lower for Black women than White women, with factors like histotype and age at diagnosis affecting outcomes.
- The study analyzed data from Nigerian patients, Caribbean-born Blacks, and US-born Blacks, revealing that Nigerians had a higher percentage of germ cell and sex-cord stromal tumors, whereas Caribbean and US-born blacks had more cases of serous ovarian cancer.
- Nigerians were diagnosed with epithelial ovarian cancers at a younger age compared to their Caribbean and US counterparts, with all Black women showing earlier diagnosis of germ cell and sex-cord stromal tumors than White women.
Background: Peptic ulcer disease (PUD) remains one of the most prevalent gastrointestinal diseases and has been linked to () infection. This condition may be suspected on clinical grounds, but diagnosis is established using upper gastrointestinal endoscopy.
Aims: To determine the correlation between the endoscopic and pathological findings among suspected PUD patients who have been referred for diagnostic upper gastrointestinal endoscopy in National Hospital Abuja.
Background: Anal precancers and cancers can be detected during screening with high-resolution anoscopy (HRA). The sensitivity of HRA depends on the burden and duration of human papillomavirus (HPV) among those screened as well as anoscopist proficiency, which is highly correlated with prior screening experience. Our objective was to compare the identification and type of HPV and the likelihood of HRA-detected precancer for men who have sex with men (MSM) undergoing their first HRA-screening in Nigeria.
View Article and Find Full Text PDFBackground: Men who have sex with men (MSM) living with HIV are at increased risk for anal cancer. We evaluated satisfaction with first-time anal cancer screening using high resolution anoscopy (HRA) as a cross sectional survey among men who have sex with men (MSM) attending a community-engaged clinic in Abuja, Nigeria.
Methods: Between March and August 2017, 342 MSM underwent screening and 307 (89%) completed a satisfaction survey that evaluated 8 domains related to expectations, convenience, staff interpersonal skills, physical surroundings, technical competence, pain/discomfort, general satisfaction, and intention to re-screen if symptomatic.
Cryptococcosis, a global disease problem, seen frequently in the immuno-suppressed, also affects patients without apparent immuno-suppression. Pulmonary cryptococcosis patients often present as cryptococcal pneumonia, whereas intracranial cryptococcosis presents with meningitis. We present a 33-year-old immunocompetent man, diagnosed with invasive pulmonary cryptococcal disease with spread to the brain.
View Article and Find Full Text PDFIntroduction: Neuronavigation has become a standard of care in contemporary neurosurgery since more than two decades and is gradually being embraced in our local practice. It is, therefore, important to share our local experience, including practical challenges encountered with this technology.
Aims And Objectives: The aim of this study is to review and present our early experience with stealth neuronavigation and to discuss the practical challenges encountered with the application of this technology in this environment.
Article Synopsis
- * By comparing gene expressions during prostate cancer regression and regrowth, researchers found that the protein soluble guanylate cyclase 1 subunit alpha plays a key role in enabling castration-resistant prostate cancer.
- * Virtual screening of 242 anti-prostate cancer phytochemicals identified (8'R)-neochrome and (8'S)-neochrome from spinach as promising drug candidates for inhibiting both normal and mutant forms of the soluble guanylate cyclase 1 protein.
Purpose: Anal cancer risk is substantially higher among HIV-infected men who have sex with men (MSM) as compared with other reproductive-age adults, but screening is rare across sub-Saharan Africa. We report the use of high-resolution anoscopy (HRA) as a first-line screening tool and the resulting early outcomes among MSM in Abuja, Nigeria.
Methods: From August 2016 to August 2017, 424 MSM enrolled in an anal cancer screening substudy of TRUST/RV368, a combined HIV prevention and treatment cohort.
Background/aims: Intracranial tumours demonstrate characteristic diagnostic histopathological features. Our aims were to look at the histo-pathological pattern of intracranial tumours in our environment including their age and sex distribution.
Methods: The histology request forms and slides of all intracranial specimens submitted to the histo-pathology department of National Hospital, Abuja, over an 11 year period (2005 and 2015) were retrospectively reviewed.