Publications by authors named "Jiazi Ma"
The exposure of humans and animals to environmental compounds is rarely restricted to a single chemical. Unfortunately, very few studies were conducted to determine cadmium and lead combined effect. The aim of this study was to clarify the neurotoxicity induced by combined exposure to lead and cadmium and its mechanism of action.
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- Coal worker's pneumoconiosis (CWP) is a serious lung disease caused by long-term exposure to coal dust, impacting the health and lifespan of miners while also straining economic resources and reducing workforce participation.
- The study analyzes trends and changes in the global impact of CWP from 1990 to 2019, anticipating shifts in how the disease affects miners due to changes in the coal industry.
- By providing a detailed overview of CWP's current and future implications, the study aims to aid countries in creating better health policies and preventive measures for coal miners.
As a small molecule, hydrogen is colorless, odorless and lightest. Many studies conducted that hydrogen can protect almost every organ, including the brain, heart muscle, liver, small intestine, and lungs. To verify whether high concentrations of hydrogen (HCH) has anti-inflammatory and antioxidant activities on respiratory system, we product a systematic review and meta-analysis.
View Article and Find Full Text PDFUnderstanding the Mechanism of Ferroptosis in Neurodegenerative Diseases.
Front Biosci (Landmark Ed)
August 2024
Neurodegenerative disorders are typified by the progressive degeneration and subsequent apoptosis of neuronal cells. They encompass a spectrum of conditions, including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), epilepsy, brian ischemia, brian injury, and neurodegeneration with brain iron accumulation (NBIA). Despite the considerable heterogeneity in their clinical presentation, pathophysiological underpinning and disease trajectory, a universal feature of these disorders is the functional deterioration of the nervous system concomitant with neuronal apoptosis.
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- Silicosis is a progressive lung disease caused by inhaling silica particles and currently has no specific treatment.
- Hydrogen combined with tetrandrine was tested on rats exposed to silica, showing significant reduction in inflammation and fibrosis markers over time.
- The study suggests that this combination may alleviate silicosis symptoms by targeting specific cellular pathways, but it acknowledges limitations in assessing lung function dynamics.
Pleckstrin homeolike domain, family A, member 1 (PHLDA1) is a multifunctional protein that plays diverse roles in A variety of biological processes, including cell death, and hence its altered expression has been found in different types of cancer. Although studies have shown a regulatory relationship between p53 and PHLDA1, the molecular mechanism is still unclear. Especially, the role of PHLDA1 in the process of apoptosis is still controversial.
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