The relationship between keratin 18 and epithelial-derived tumors: as a diagnostic marker, prognostic marker, and its role in tumorigenesis.

As a structural protein, keratin is mainly expressed in epithelial cells and skin appendages to provide mechanical support and external resistance. The keratin family has a total of 54 members, which are divided into type I and type II. Two types of keratins connect to each other to form keratin intermediate filaments and participate in the construction of the cytoskeleton.

[Effect of folic acid coated-crosslinked urethane-doped polyester elastomer nerve conduit on promoting the repair of long distance peripheral nerve injury in rats].

Objective: To investigate the effect of folic acid coated-crosslinked urethane-doped polyester elastomer (fCUPE) nerve conduit in repairing long distance peripheral nerve injury.

Methods: Thirty-six 3-month-old male Sprague Dawley rats weighing 180-220 g were randomly assigned to 3 groups, each consisting of 12 rats: CUPE nerve conduit transplantation group (group A), fCUPE nerve conduit transplantation group (group B), and autologous nerve transplantation group (group C), the contralateral healthy limb of group C served as the control group (group D). A 20-mm-long sciatic nerve defect model was established in rats, and corresponding materials were used to repair the nerve defect according to the group.

Simultaneous solubilization and extended release of insoluble drug as payload in highly soluble particles of γ-cyclodextrin metal-organic frameworks.

The inclusion and nanocluster formed in cyclodextrin-metal organic framework (CD-MOF) make it a remarkable vehicle in improving the solubility and bioavailability of insoluble drugs, but rarely in elongation of drug release kinetics. In this research, an insoluble compound, 18β-glycyrrhetinic acid (GA), encapsulated in CD-MOF (GA@nano-CD-MOF) had prominent effects in the treatment of bleomycin-induced idiopathic pulmonary fibrosis in rats with an enhanced bioavailability by 6.8 times.

Influence of volar margin of the lunate fossa fragment fixation on distal radius fracture outcomes: A retrospective series.

Background: Distal radius fractures accompanied by the volar margin of the lunate fossa (VMLF) lesions are often overlooked or inadequately reduced in clinical practice.

Aim: To investigate the impact of VMLF fragment in distal radius fractures on the stability and function of the wrist joint.

Methods: This was a retrospective study of patients with distal radius fractures who underwent surgical treatment between January 2013 and December 2017.

A double-network hydrogel for the dynamic compression of the lumbar nerve root.

Current animal models of nerve root compression due to lumbar disc herniation only assess the mechanical compression of nerve roots and the inflammatory response. Moreover, the pressure applied in these models is static, meaning that the nerve root cannot be dynamically compressed. This is very different from the pathogenesis of lumbar disc herniation.

Folic acid contributes to peripheral nerve injury repair by promoting Schwann cell proliferation, migration, and secretion of nerve growth factor.

After peripheral nerve injury, intraperitoneal injection of folic acid improves axon quantity, increases axon density and improves electromyography results. However, the mechanisms for this remain unclear. This study explored whether folic acid promotes peripheral nerve injury repair by affecting Schwann cell function.

The critical chemical and mechanical regulation of folic acid on neural engineering.

The mandate of folic acid supplementation in grained products has reduced the occurrence of neural tube defects by one third in the U.S since its introduction by the Food and Drug Administration in 1998. However, the advantages and possible mechanisms of action of using folic acid for peripheral nerve engineering and neurological diseases still remain largely elusive.

Non-invasive quantification of age-related changes in the vertebral endplate in rats using in vivo DCE-MRI.

Background: Small animal models that can mimic degenerative disc disease (DDD) are commonly used to examine DDD progression. However, assessments such as histological studies and macroscopic measurements do not allow for longitudinal studies because they can only be completed after the animal is sacrificed. Dynamic contrast-enhanced MRI (DCE-MRI) may provide a reliable, non-invasive in vivo method for detecting the progression.

[The Biomechanics Influence of unilateral laminectomy and discectomy surgery on the adjacent different grades of Disc Degeneration].

Objectives: To study the stress distribution of the adjacent different grades of disc degeneration underwenting unilateral laminectomy and discectomy surgery using non-linear finite element analysis.

Methods: Based on the lumbar CT scans, the finite element model (FEM) of lumbar spinal segment (L3-L5) was established. According to L3-L4 intervertebral disc degeneration, different grades of disc degeneration (healthy, mild, moderate and severe) models were established and unilateral laminectomy and discectomy surgery were also established.

Finite element analysis in adjacent segment degeneration after lumbar fusion.

Background: Adjacent segment degeneration (ASD) following lumbar fusion has been well documented in recent years. However, the pathogenesis of ASD is not clear. To investigate this issue, we established a finite element model of segments L2-L5, simulated a single-segment posterior fixation in L3-L4 and investigated the stress variation and the effects of the instrumented lumbar posterior fixation on adjacent levels.

[Finite element analysis of adolescent idiopathic scoliosis of PUMC II d2 surgical treatment with different fusion levels].

Objective: To explore the best surgical fusion level for adolescent idiopathic scoliosis (AIS) of PUMC II d(2) with finite element model (FEM).

Methods: FEM (T(5)-S) of PUMC II d(2) idiopathic scoliosis was used to simulate upper thoracic curve, lower lumbar curve and double curve fusion manners. The pedicle of concave vertebral arch received 50, 100 and 150 N load respectively.

Histological analysis of single peripheral nerve fiber in acute nerve elongation process.

To observe the histological alterations of single nerve fiber structures after nerve elongation by employing a rabbit peroneal nerve stretching model. 14 rabbits weighing mean 3. 0 kg (2.

[Association study of Trp2 allele polymorphism with degenerative disc disease in a Chinese Han nationality].

Objective: To investigate the association between Trp2 allele polymorphism with degenerative disc disease (DDD) in a Chinese Han population.

Methods: A total of 125 DDD patients (58 males and 67 females, 51.8 +/- 7.

[Finite element analysis on stress change of the lumbar disc degeneration].

Objective: To investigate the mechanical changes of the degenerated lumbar disc with finite element analysis.

Methods: A three dimensional finite element model of a human lumbar spine at the L3-L4 disc was established by the software MIMICS and ABAQUS based on computer tomography images. Degeneration was modeled by changes in geometry and material properties.

[Assessment of correction effect in relation to fulcrum bending flexibility in adult idiopathic scoliosis patients].

Objective: To study the relationship between the fulcrum bending flexibility (FBF) and correction rate (CR) of adult idiopathic scoliosis, and to explore the ability of FBF to assess the correction effect in relation to fulcrum bending flexibility.

Methods: 69 patients with adult idiopathic scoliosis with structural curves at thoracic or lumbarthoracic segments, 16 males and 53 females, aged 26.5 (19 - 53) were treated by pedicle screws instrumentation.

[Finite element analysis on stress change of lumbar spine].

Objective: To build a 3D finite element model of whole lumbar spine and verify its efficiency and analyze the biomechanical change of L3-4 motion segment.

Methods: L1-L5 segment data were obtained from computed tomography (CT) scans of the lumbar spine of a 40-year-old man with no abnormal findings. A three-dimensional finite element model of the human whole lumbar spine was built in the Mimics and the ABAQUS software.

[Finite element analysis of stress changes of posterior spinal pedicle screw infixation].

Objective: To evaluate the mechanical response of L3-L4 segment after posterior interfixation with a transpedicle screw system.

Methods: Spiral CT machine was used to conduct continuous parallel scan on the L3-L4 section of a 40-year-old healthy male Chinese. The image data thus obtained were introduced into MIMICS software to reconstruct the 2-D data into volume data and obtain 3-D models of every element.

[Imaging diagnosis of degenerative scoliosis and adult idiopathic scoliosis].

Objective: To analyze and compare the Imaging findings of adult idiopathic scoliosis and degenerative scoliosis which were the most common adult scoliosis, and evaluate imaging characteristics.

Method: The radiological and clinical data of 98 case, among them, 41 cases of adult idiopathic scoliosis and 57 cases of degenerative scoliosis, were analyzed retrospectively.

Result: There were differences at presence age, sex ratio, anatomic area of scoliosis and apex between two types of adult scoliosis.

Dynamic observation of biomechanic properties of sciatic nerve at the suture site in rats following repairing.

To observe the biomechanic properties of the sciatic nerve at the suture site following repairing in rats. The right sciatic nerves of 40 white Sprague-Dawley 300~350 gm rats were exposed, cut and then repaired with 10-0 nylon sutures with four stitches, laced in the epineurium 0, 1, 3, and 6 weeks after operation, the tensile strength of the sciatic nerves were measured, and the data analyzed statistically. The load elongation curves for both the normal unoperated and operated nerves had similar shape.

[Dynamic observation of the biomechanic properties of sciatic nerve at the suture site in rats following repairing].

Objective: To observe the biomechanic properties of sciatic nerve at the suture site in rats following repairing.

Methods: The right sciatic nerves of 40 white Sprague-Dawley 300-350 gm rats were exposed, cut and then repaired with 10-0 nylon sutures, laced in the epineurium. 0, 1, 3, 6 weeks after operation, the tensile strength of the sciatic nerves were measured, the data analyzed statistically.