Optimization Design of a Multi-String Standing Wave Electrospinning Apparatus Based on Electric Field Simulations.

The mass production of uniform, high-quality polymer nanofibers remains a challenge. To enhance spinning yield, a multi-string standing wave electrospinning apparatus was developed by incorporating a string array into a standing wave electrospinning device. The process parameters such as string spacing, quantity, and phase difference were optimized, and their effects on the electric field distribution within the spinning area were analyzed using electric field simulations.

Demonstration of 120 Gbit/s turbulence-resilient coherent optical communication employing cylindrical vector beam multiplexing.

Free space optical (FSO) communication has gained widespread attention due to its advantages, including high confidentiality, high communication capacity, and no limitation of spectrum. One of the great challenges in FSO communication is the transmission performance degradation in atmospheric turbulence channel due to wavefront distortion and scintillation. Here, we proposed and experimentally demonstrated a 120 Gbit/s vector beam multiplexed coherent optical communication system with turbulence-resilient capacity.

URI1 suppresses irradiation-induced reactive oxygen species (ROS) by activating autophagy in hepatocellular carcinoma cells.

Radiotherapy has been extensively applied in cancer treatment. However, this treatment is ineffective in Hepatocellular carcinoma (HCC) due to lack of radiosensitivity. Unconventional prefoldin RPB5 interactor 1 (URI1) exhibits characteristics similar to those oncoproteins, which promotes survival of cancer cells.

PD-L1/LAG-3 bispecific antibody enhances tumor-specific immunity.

Anti-programmed cell death-1 (PD-1)/PD-ligand-1 (PD-L1) treatments are effective in a fraction of patients with advanced malignancies. However, the majority of patients do not respond to it. Resistance to cancer immunotherapy can be mediated by additional immune checkpoints.

Combined strategies for effective cancer immunotherapy with a novel anti-CD47 monoclonal antibody.

CD47 is a widely expressed cell-surface protein that regulates phagocytosis mediated by cells of the innate immune system, such as macrophages and dendritic cells. CD47 serves as the ligand for a receptor on these innate immune cells, signal regulatory protein (SIRP)-α, which in turn inhibits phagocytosis. Several targeted CD47 therapeutic antibodies have been investigated clinically; however, how to improve its therapeutic efficacy remains unclear.

Impact of Equalization-Enhanced Phase Noise on Digital Nonlinearity Compensation in High-Capacity Optical Communication Systems.

Equalization-enhanced phase noise (EEPN) can severely degrade the performance of long-haul optical fiber transmission systems. In this paper, the impact of EEPN in Nyquist-spaced dual-polarization quadrature phase shift keying (DP-QPSK), dual-polarization 16-ary quadrature amplitude modulation (DP-16QAM), and DP-64QAM optical transmission systems is investigated considering the use of electrical dispersion compensation (EDC) and multi-channel digital backpropagation (MC-DBP). Our results demonstrate that full-field DBP (FF-DBP) is more susceptible to EEPN compared to single-channel and partial-bandwidth DBP.

RMP/URI inhibits both intrinsic and extrinsic apoptosis through different signaling pathways.

The evading apoptosis of tumor cells may result in chemotherapy resistance. Therefore, investigating what molecular events contribute to drug-induced apoptosis, and how tumors evade apoptotic death, provides a paradigm to explain the relationship between cancer genetics and treatment sensitivity. In this study, we focused on the role of RMP/URI both in cisplatin-induced endogenous apoptosis and in TRAIL-induced exogenous apoptosis in HCC cells.