Publications by authors named "Jiayun Tan"

To increase pancreatic tumor-targeted phototoxicity of photosensitizers, a hyperbranched cationic amylopectin derivative conjugated with 3-(dimethylamino)-1-propylamine (DMAPA-Amp) was invevstigated as a multi-guest molecular host for the targeted delivery of a photosensitizer to human pancreatic cancer (Panc-1) cells. We selected protoporphyrin IX (PpIX) and folic acid as a photosensitizer and a tumor-targeting factor, respectively. The complexation mechanism of DMAPA-Amp with PpIX and folic acid was characterized using NMR spectroscopy including H NMR, two-dimensional diffusion ordered spectroscopy (2D DOSY) NMR, fluorescence and UV-vis spectroscopy.

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Background: Diabetic retinopathy is the most common complication in diabetic patients relates to high expression of VEGF and microaneurysms. Scutellarin (Scu) turned out to be effective against diabetes related vascular endothelial cell dysfunction. However, its clinical applications have been limited by its low bioavailability.

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To improve the small intestinal absorption efficacy of Astragalus polysaccharides (APS) through oral administration, amphiphilic chitosan derivatives conjugated with deoxycholic acid residues in the absence and presence of vitamin B residues (DA-Chit and VB-DA-Chit, respectively) were synthesized and characterized by FTIR and NMR spectroscopy. APS and the amphiphilic chitosan derivatives formed the nano-complexes with positive zeta potentials in the size of 100-150nm observed using scanning electron microscopy. To investigate the fluorescent properties of APS, a Congo red residue-conjugated APS derivative (CR-APS) was synthesized.

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Amylopectin is a naturally hyperbranched biopolymer with an extremely high molecular weight. Furthermore, this material is non-toxic in nature, and exhibits good biocompatibility and biodegradability properties. Herein, we describe the development of a one-step reaction strategy for the synthesis of amphiphilic high-molecular-weight hyperbranched amylopectin derivatives with hydrophobic shells and large hydrophilic cores.

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