Publications by authors named "Jiayun Liu"
Dermatosis Neglecta and Chilblain Lupus Erythematosus Occurred Post Surgery of Basal Cell Carcinoma: A Case Report.
Clin Cosmet Investig Dermatol
February 2025
Dermatosis neglecta (DN) is a rare condition, often linked to psychosomatic disorders, with an unclear etiology. Chilblain lupus erythematosus (CHLE) constitutes a rare variant of cutaneous lupus erythematosus, frequently mistaken for idiopathic chilblain due to its chilblain-like lesions. To date, no instances of concurrent DN and CHLE occurring at the site of a skin flap or graft have been documented.
View Article and Find Full Text PDFBackground & Aims: The effect of transarterial chemoembolization (TACE) plus radiofrequency ablation (RFA) (TACE-RFA) for hepatocellular carcinoma (HCC) in high-risk locations is not satisfactory. The aim of this study was to compare the clinical outcomes of TACE-RFA plus iodine-125 (I) seed implantation (TACE-RFA-I) therapy with those of TACE-RFA for unresectable HCC (≤5 cm) in high-risk locations.
Methods: From January 2010 to June 2023, the clinical data of 126 patients with unresectable HCC (≤5 cm) in high-risk locations who received TACE-RFA-I or TACE-RFA treatment were retrospectively analyzed.
Objective: This study sought to conduct a meticulous systematic review, delving into the efficacy of exercise interventions on depressive symptoms among middle-aged and older adults. Additionally, we aimed to scrutinize the nuanced influence of various intervention factors on the intricate relationship between exercise and depressive symptoms within this demographic.
Methods: Our investigation involved an extensive search across multiple databases, including PubMed, Embase, Web of Science, and the Cochrane Library, spanning from the inception of these repositories to December 2023.
Background: Melanoma is an aggressive skin tumor with limited therapeutic options due to rapid proliferation, early metastasis, and poor prognosis. Baicalin (BA), a natural flavonoid, shows promise in inducing ferroptosis and apoptosis but faces challenges of poor solubility and bioavailability. To address these issues, we developed a multifunctional drug delivery system: manganese-doped ZIF-8 nanoparticles (ZIF(Mn)) loaded with BA and modified with folic acid (FA) and polyethylene glycol (PEG).
View Article and Find Full Text PDF: To investigate the diagnostic value of oviduct glycoprotein 1 (OVGP1) levels for polycystic ovary syndrome (PCOS). : Serum OVGP1 concentrations were measured by enzyme-linked immunosorbent assay (ELISA). Associations between OVGP1 and endocrine parameters were evaluated by Spearman's correlation analysis.
View Article and Find Full Text PDFNew Delhi metallo-β-lactamase-1 (NDM-1)-producing bacteria are resistant to nearly all available β-lactam antibiotics and have become a public health threat. Antibiotic resistance often carries fitness costs, which typically manifest as a reduced bacterial growth rate. Here, we investigated the mechanism of fitness cost in NDM-1-producing bacteria.
View Article and Find Full Text PDF[Research progress on the role of exosomes in respiratory diseases].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
November 2024
Exosomes are extracellular vesicles that can be secreted by various cells and widely exist in body fluids such as blood and urine. During the progression of respiratory tract diseases, exosomes derived from epithelial and immune cells can secrete substances such as RNA and proteins, disrupting the respiratory defense system and inducing or exacerbating the disease. Exosomes derived from circulating and lung tissues can be used as potential diagnostic markers for respiratory diseases, which greatly improves the diagnostic sensitivity and specificity for respiratory diseases such as tumors and infections.
View Article and Find Full Text PDFObjective: The relationship between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and psoriasis remains unclear. This study aims to analyze the association between ACE gene I/D polymorphism and the risk of psoriasis vulgaris in the Chinese Han population and to examine the correlation between ACE gene I/D polymorphism and psoriasis with comorbid hypertension and diabetes.
Methods: A total of 358 patients with psoriasis vulgaris and 347 age- and sex-matched healthy volunteers from the Chinese Han population were selected.
Article Synopsis
- The study investigated how changes in amino acids and carnitine metabolism affect non-pregnant women with infertility, pregnant women without infertility, and infertility-treated pregnant women by analyzing 496 samples using advanced chromatography techniques.
- Researchers utilized multiple screening methods and algorithms to create and validate models for diagnosing infertility and pregnancy, achieving high accuracy metrics.
- Results suggest that pregnancy influences amino acid and carnitine metabolism in women with infertility, and the developed models show strong potential for improving diagnosis in these areas.
Article Synopsis
- Intracerebral hemorrhage (ICH) is a serious type of stroke with high rates of complications and no existing clinical biomarkers to diagnose it.
- The study involved analyzing blood samples from patients with ICH, ischemic stroke, hypertension, and healthy controls to identify RNA molecules that could serve as potential diagnostic biomarkers.
- Results showed significant differences in gene expression between ICH patients and controls, leading to the identification of a promising RNA panel (CKAP4, BCL6, TLR8) that demonstrates high diagnostic accuracy for ICH.
Article Synopsis
- Rosacea is a chronic skin condition that causes facial redness and visible blood vessels, with its exact causes still unclear, and current treatments not fully effective.
- The study investigated the effects of the JAK inhibitor tofacitinib on rosacea, showing promising results in a mouse model where it reduced inflammation and improved skin appearance.
- In patients, oral tofacitinib also led to significant improvements in redness and flushing, indicating its potential as a new therapeutic option targeting the JAK/STAT signaling pathway in rosacea treatment.
Article Synopsis
- - The study focuses on a family with a genetic deficiency in coagulation factor XII (FXII), aiming to understand its clinical characteristics and the mutations involved in the condition.
- - Diagnostic methods included measuring activated partial thromboplastin time (APTT) and FXII activity, alongside genetic analysis using Sanger sequencing and software for mutation impact assessment.
- - Findings reveal two harmful missense mutations (p.Gly175Cys and p.Gly542Ser) in the FXII gene, with the p.Gly175Cys mutation being identified for the first time globally, highlighting its role in hereditary FXII deficiency.
Past research supports the detrimental effects of parental psychological control on adolescent school adjustment in both emotional and academic domains. However, how psychological control changes during adolescence, and how such developmental course is related to adolescent psychological well-being and academic functioning are unclear. The direction of effects between parenting and child behaviors is also inconclusive.
View Article and Find Full Text PDFArticle Synopsis
- Valleytronics focuses on using the valley degree of freedom for creating energy-efficient electronic devices, highlighting the importance of manipulating valley information at room temperature in thick materials.
- The researchers successfully observed a circular photocurrent in few-layer molybdenum disulfide (MoS) through scanning photocurrent microscopy, indicating a lower system symmetry compared to bulk MoS.
- They also found that the photocurrent polarity can be reversed using electrical bias, suggesting that valley information can be maintained in thick-layer MoS and presenting new avenues for developing multilayer valleytronics devices through interface engineering.
Novel Providencia xianensis sp. nov.: A multidrug-resistant species identified in clinical infections.
Eur J Clin Microbiol Infect Dis
July 2024
Article Synopsis
- Researchers found two strains of bacteria originally thought to be Providencia rettgeri, but genome analysis revealed they are distinct enough to be classified as a new species named Providencia xianensis.
- The new strains demonstrate multidrug resistance and are resistant to last-resort antibiotics, indicating a serious public health threat.
- Their discovery highlights the need for increased monitoring and proactive measures to combat the spread of these emerging, drug-resistant pathogens.
Article Synopsis
- Radiofrequency ablation (RFA) is a non-surgical treatment option for some malignant solid tumors, but it may leave residual cancer cells, especially in larger tumors or those near large blood vessels due to the "heat-sink" effect.
- Sublethal radiofrequency hyperthermia (RFH) can enhance the effectiveness of RFA when combined with other therapies (chemotherapy, radiotherapy, immunotherapy, gene therapy) by improving tumor response and reducing viable tumor margins.
- Mechanisms of RFH's enhancement include tissue fracturing, increased cell membrane permeability, boosted metabolism, disruption of repair pathways in damaged cells, and activation of heat shock proteins, which collectively contribute to lower rates of residual and recurrent tumors.
Article Synopsis
- - 3M syndrome is a rare genetic disorder characterized by severe growth retardation and specific physical features, but typically does not affect mental development or organs; identified genes are crucial for diagnosis.
- - A case study highlighted a patient with unusual symptoms and no typical facial features associated with 3M syndrome, leading to genetic testing which revealed a new and previously unreported genetic variant.
- - The findings underscore the variability in clinical features of 3M syndrome and the importance of genetic testing for accurate diagnosis, contributing to a broader understanding of the disorder's molecular profile.
Article Synopsis
- * Researchers explored how miRNA expression, specifically miR-337-3p, affects nerve cell survival during hypoxia-induced stress, finding that downregulation of miR-337-3p led to increased expression of KCTD11, promoting cell death.
- * This study identifies the miR-337-3p/KCTD11 axis as a potential regulatory mechanism that could help in developing therapies to improve nerve cell survival in hypoxic conditions.
Article Synopsis
- Radiofrequency ablation (RFA) is increasingly used for early-stage liver cancer (HCC), but large tumors present challenges in achieving effective treatment margins.
- This study explores combining RFA with OK-432, which activates the cGAS-STING pathway, and finds that radiofrequency hyperthermia (RFH) boosts this effect and TLR4 expression, potentially improving treatment outcomes.
- The results indicate that using RFH alongside OK-432 offers better tumor response and longer survival rates for patients with large, irregular HCCs, suggesting a promising new treatment strategy.
Article Synopsis
- * Findings show that about 23.3% of urine total EVs contain DNA, with larger fragments present and little effect from urine storage for less than 6 hours at 4°C.
- * Notably, RASSF1A methylation in urine EV DNA achieved a strong diagnostic accuracy (AUC of 0.874) for differentiating PCa from BPH, highlighting its promise as a new urinary tumor marker.
Article Synopsis
- The study analyzes key researchers in vocational education and training (VET) using a scientometric approach on 2,024 articles from the Web of Science.
- It finds that VET research is interdisciplinary, involving fields like psychology, sociology, economics, and pedagogy.
- The US, Netherlands, and Australia are the top contributors, with key research institutions including the University of Amsterdam, University of Utrecht, and University of Melbourne. Major research hotspots include topics like engagement, self-efficacy, and labor market predictors.
[Analysis of a Chinese pedigree affected with Hereditary coagulation factor Ⅻ deficiency due to compound heterozygous variants of F12 gene].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
December 2023
Article Synopsis
- A study was conducted on a Chinese family to investigate hereditary coagulation factor XII (FⅫ) deficiency, focusing on clinical features and genetic mutations.
- Testing showed a prolonged activated partial thromboplastin time (APTT) and significantly low levels of FⅫ activity and antigen in one family member, the proband.
- DNA analysis identified two harmful genetic variants in the F12 gene, suggesting these mutations are likely responsible for the family's FⅫ deficiency.
Article Synopsis
- - The study explored an injectable hydrogel (ROD) containing lysed OK-432 (lyOK-432) and doxorubicin (DOX) to treat residual liver cancer following incomplete radiofrequency ablation (iRFA) of hepatocellular carcinoma (HCC).
- - Results showed that lyOK-432 enhanced dendritic cell activation and improved immune response more effectively than OK-432 alone, leading to increased tumor necrosis and longer survival rates in treatment groups.
- - The ROD hydrogel successfully stimulated antitumor immunity by activating the cGAS/STING/IFN-I signaling pathway, indicating its potential as an effective therapy for residual liver cancer post-iRFA.