Publications by authors named "Jiayuan Lei"
Article Synopsis
- Aberrant lipid metabolism is linked to endometrial cancer, prompting the study of statins as potential therapies, using Mendelian randomization (MR) to explore lipid traits' impact on the cancer.
- The study employed two-sample MR, finding no causal relationship between genetically predicted lipid traits and endometrial carcinoma, but identifying drug targets like apolipoprotein B (APOB) and cholesteryl ester transfer protein (CETP) as relevant.
- Conclusions indicated no direct link between lipid traits (LDL-C, TG, TC, HDL-C) and endometrial cancer, yet highlighted APOB's association with lower risk and CETP's with higher risk for endometrioid carcinoma, pointing to