Atrial Fibrillation Types and Chronic Kidney Disease are Independent Predictors of Atrial Fibrillation Recurrence After Radiofrequency Ablation.

Purpose: Atrial fibrillation (AF) is classified into paroxysmal, persistent, long-term persistent, and permanent types. It is commonly treated by radiofrequency ablation (RFA), which is more successful than conventional anti-arrhythmic drugs, but it is still largely unknown whether these beneficial effects are equally present for all AF types. Here, we evaluated the impact that AF type has on post-RFA patient conditions and identified underlying factors affecting AF prognoses.

Predictive Modeling with Temporal Graphical Representation on Electronic Health Records.

Deep learning-based predictive models, leveraging Electronic Health Records (EHR), are receiving increasing attention in healthcare. An effective representation of a patient's EHR should hierarchically encompass both the temporal relationships between historical visits and medical events, and the inherent structural information within these elements. Existing patient representation methods can be roughly categorized into sequential representation and graphical representation.

High-Performance 2D Ambipolar MoTe Lateral Memristors by Mild Oxidation.

2D transition metal dichalcogenides (TMDCs) have been intensively explored in memristors for brain-inspired computing. Oxidation, which is usually unavoidable and harmful in 2D TMDCs, could also be used to enhance their memristive performances. However, it is still unclear how oxidation affects the resistive switching behaviors of 2D ambipolar TMDCs.

Comprehensive molecular evolutionary analysis of small heat shock proteins in five diploid Gossypium species.

The small heat shock proteins (sHSPs) are important components in plant growth and development, and stress response. However, a systematical understanding of the sHSP family is yet to be reported in five diploid Gossypium species. In this study, 34 GlsHSPs, 36 GrsHSPs, 37 GtsHSPs, 37 GasHSPs, and 38 GhesHSPs were identified in Gossypium longicalyx, Gossypium raimondii, Gossypium turneri, Gossypium arboreum, and Gossypium herbaceum, respectively.

Direct abdominal vein thrombus imaging (DATI): a contrast-free black-blood MR technique for the diagnosis of abdominal vein thrombosis.

Objectives: To develop and evaluate a direct abdominal vein thrombus imaging (DATI) technique, based on a respiratory navigating SPACE sequence with DANTE black-blood preparation, for diagnosing abdominal vein thrombosis (AVT) without the use of exogenous contrast agents.

Methods: We prospectively enrolled 10 healthy subjects and 28 suspected AVT patients who underwent DATI scans on 3.0 T MRI.

Serum albumin is associated with the inherent property of acute myeloid leukemia and correlates with patient outcomes.

An accurate prognostic model for acute myeloid leukemia (AML) can guide personalized treatment. In our prospective cohort of 591 patients newly diagnosed with AML, we evaluated the prognostic significance of serum albumin levels. We recognized baseline serum albumin as a prognostic factor by univariate Cox regression analysis (albumin-high vs albumin-low: overall survival [OS]: hazard ratio [HR]: 0.

Wet adhesive hydrogels based on niobium carbide for experimental research of oral mucosal impairment.

Oral mucosal impairment is a prevalent oral disease that frequently causes pain for patients. Conventional treatments have limited effectiveness and can cause adverse reactions. Furthermore, the moist and dynamic nature of the oral mucosal environment makes persistent adherence of conventional materials challenging, which can affect treatment efficacy.

Identification of red blood cell distribution width as a prognostic factor in acute myeloid leukemia.

Many prognostic factors have been identified in acute myeloid leukemia (AML). In this study, we investigated novel prognostic biomarkers using machine learning and Cox regression models in a prospective cohort of 591 patients with AML and tried to identify potential therapeutic targets based on transcriptomic data. We found that elevated red blood cell distribution width (RDW) at diagnosis was an adverse prognostic factor for AML, independent of the 2022 European LeukemiaNet (ELN2022) genetic risk.

[Effects and Mechanisms of Homoharringtonine on Expression of CEBPA Protein].

Objective: To investigate the effect of homoharringtonine (HHT) on CEBPA protein and explore the mechanism of HHT in the treatment of acute myeloid leukemia (AML) with double mutations.

Methods: The K562 cell line expressing p30 (K562 p30) was established. Western blot was used to determine the changes of the expression of CEBPA protein in K562 p30, U937 and MOLM-13 cell lines before and after treatments with HHT, daunorubicin (DNR) or cytarabine (Ara-C).

Acteoside ameliorates learning and memory impairment in APP/PS1 transgenic mice by increasing Aβ degradation and inhibiting tau hyperphosphorylation.

Alzheimer's disease (AD) is a neurodegenerative disease. Senile plaques and intracellular neurofibrillary tangles are pathological hallmarks of AD. Recent studies have described the improved cognitive and neuroprotective functions of acteoside (AS).

NRVC: Neural Representation for Video Compression with Implicit Multiscale Fusion Network.

Recently, end-to-end deep models for video compression have made steady advancements. However, this resulted in a lengthy and complex pipeline containing numerous redundant parameters. The video compression approaches based on implicit neural representation (INR) allow videos to be directly represented as a function approximated by a neural network, resulting in a more lightweight model, whereas the singularity of the feature extraction pipeline limits the network's ability to fit the mapping function for video frames.

Long-Wavelength Near-Infrared Divalent Nickel-Activated Double-Perovskite BaMgWO Phosphor as Imaging for Human Fingers.

Transmission near-infrared (NIR) imaging technology has great potential for biomedical imaging because of its lower water absorption coefficient and highly reduced photon scattering effect in biological tissues compared to visible light. The extent of biological tissue photon scattering is inversely proportional to wavelength; therefore, in principle, imaging with long-wavelength NIR helps improve the resolution of the optical image, but deep tissue high-resolution luminescence imaging is still very challenging technically. Here, we report the discovery of a BaMgWO:Ni double perovskite phosphor that emits broadband long-wavelength NIR (1200-2000 nm) under 365 nm near-ultraviolet (UV) excitation, with a full width at half-maximum of 255 nm.

Prediction of prognosis in COVID-19 patients using machine learning: A systematic review and meta-analysis.

Background: Accurate prediction of prognostic outcomes in patients with COVID-19 could facilitate clinical decision-making and medical resource allocation. However, little is known about the ability of machine learning (ML) to predict prognosis in COVID-19 patients.

Objective: This study aimed to systematically examine the prognostic value of ML in patients with COVID-19.

Activatable Mn-Armed nanoagonist augments antitumor immunity in colorectal cancer: A NIR-II Photonic neoadjuvant paradigm.

Postoperative recurrence frequently occurs in patients with colorectal cancer (CRC) due to residual microtumors and host cellular immune dysfunction, leading to major setbacks in clinical outcomes and CRC staging. As an increasingly prevalent therapeutic option for CRC patients, neoadjuvant chemoradiotherapy bears unmet challenges of limited tumor targeting and common side effects of gastrointestinal reaction and radiodermatitis. It is highly desirable to develop neoadjuvant treatment paradigms that impart both tumor-targeting accuracy and protection against recurrence of resectable CRC.

Assessment of Instant Loss of Elbow Flexion in Children with Untreated Gartland IIA Humeral Supracondylar Fractures-A Simulation Study with Lateral Elbow Radiographs.

Objective: The suitability of in situ cast fixation for treating Gartland IIA humeral supracondylar fractures has remained controversial due to concerns regarding loss of elbow flexion. This study aimed to assess the instant loss of elbow flexion after Gartland IIA humeral supracondylar fractures based on the relationship between the anterior marginal line of the humerus and capitellum in the lateral view.

Methods: This simulation study was conducted with normal radiographs using Adobe Photoshop 14.

Engineering CsPbX (X = Cl, Br, I) Quantum Dot-Embedded Borosilicate Glass through Self-Crystallization Facilitated by NaF as a Phosphor for Full-Color Illumination and Laser-Driven Projection Displays.

All inorganic perovskite (CsPbX, X = Cl, Br, I) quantum dot (QD) glass samples are considered the next generation of lighting materials for their excellent luminescence properties and stability, but crystallization conditions are difficult to control, which often leads to the inhomogeneous crystallinity of QDs. Here, we provided evidence that the presence of sodium fluoride induced self-crystallization of CsPbBr QDs during routine glass formation without the need for additional heat treatment. We showed that NaF simultaneously affected the network structure of glass and promoted the formation of CsPbBr QDs, that is, Na ions entered the glass network skeleton, partially interrupting the network structure, while the strong electronegativity of F ions attracted Cs and Pb ions into the gaps formed in the glass networks that had been loosened up by Na ions, which reduced the activation energy of crystallization processes.

Serum sirtuin-1 a potential marker in the diagnosis of rheumatoid arthritis.

To explore the value of serum sirtuin-1 (SIRT1) in the diagnosis and evaluation of joint mobility of rheumatoid arthritis (RA). Serum was randomly obtained from 212 RA patients,210 non-RA patients and 58 healthy controls in a large tertiary first-class hospital in Jiangxi province from November 2021 to June 2022. The level of serum Sirt1,anti-cyclic citrulline polypeptide antibody (anti-CCP), anti-mutant citrulline vimentin antibody (anti-MCV), rheumatoid factor (RF),high-mobility group box 1 (HMGB1), collagen triple helix repeat containing 1 (CTHRC1), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were detected by ELISA, to explore the correlation between them and their value in the diagnosis and evaluation of joint range of motion of RA and statistically analyse their diagnostic efficiency.

Multi-omics profiling of cholangiocytes reveals sex-specific chromatin state dynamics during hepatic cystogenesis in polycystic liver disease.

Background & Aims: Cholangiocytes transit from quiescence to hyperproliferation during cystogenesis in polycystic liver disease (PLD), the severity of which displays prominent sex differences. Epigenetic regulation plays important roles in cell state transition. We aimed to investigate the sex-specific epigenetic basis of hepatic cystogenesis and to develop therapeutic strategies targeting epigenetic modifications for PLD treatment.

Effect of Arbuscular Mycorrhiza Fungus Inoculation on and Growth, Cadmium Uptake, and Soil Cadmium Speciation in Cadmium-Contaminated Soil.

Cadmium (Cd) pollution has become aggravated during the past decades of industrialization, severely endangering human health through its entry into the food chain. While it is well understood that arbuscular mycorrhizal fungi (AMF) have a strong ability to regulate plant growth and Cd uptake, studies investigating how they affect soil Cd speciation and influence Cd uptake are limited. We designed a pot experiment comprising two AMF-inoculant groups (inoculation with or no inoculation), three Cd concentration levels (0, 5, and 15 mg/kg), and two plant species ( and ) to study the effect of AMF on plant growth, Cd uptake, and Cd speciation in the soil.

Tumor CEMIP drives immune evasion of colorectal cancer via MHC-I internalization and degradation.

Background: Loss of major histocompatibility complex class I (MHC-I) in tumor cells limits the use of immune checkpoint blockade (ICB) in colorectal cancer. Nevertheless, the regulatory mechanism of MHC-I downregulation in tumor cells has not been fully elucidated. Overexpression of CEMIP in tumor tissues is associated with a poor prognosis in colorectal cancer.

Effects of Arbuscular Mycorrhizal Fungi and Biochar on Growth, Nutrient Absorption, and Physiological Properties of Maize ( L.).

Arbuscular mycorrhizal fungi (AMFs) and biochar are two common alternatives to chemical fertilizers applied to soil to improve crop growth. However, their interactive effects on maize ( L.) growth, nutrient absorption, and physiological properties remain poorly understood.

A predictive model of macrosomic birth based upon real-world clinical data from pregnant women.

Background: Fetal macrosomia is associated with an increased risk of several maternal and newborn complications. Antenatal predication of fetal macrosomia remains challenging. We aimed to develop a nomogram model for the prediction of macrosomia using real-world clinical data to improve the sensitivity and specificity of macrosomia prediction.

Bacteria-mediated metformin-loaded peptide hydrogel reprograms the tumor immune microenvironment in glioblastoma.

The tumor immune microenvironment (TIME) is one of the significant hallmarks of cancer and has the important role of largely determining the malignancy level of tumors. As an approach to break through this bottleneck of tumor treatment methods, the TIME can be reprogrammed by certain nanomaterials. Here, we coated C-novyi-spores with melittin-RADA nanofiber hybrid peptide and loaded the immunomodulator metformin to obtain MRM-coated spores as a powerful antitumor nanodrug against glioblastoma (GBM), which is based on the activation of the TIME.