Publications by authors named "Jiayu Yang"

Background: Plasma metabolite levels in patients with pancreatic cancer (PC) have changed, but the relationship between the altered plasma metabolites and the risk for PC occurrence is not fully clear, as well as the predictive value of the specific metabolites.

Methods: In this study, we obtained the metabolomics data of 243,145 people from the UK Biobank. An extreme gradient boosting (XGBoost) model, least absolute shrinkage and selection operator (Lasso) regression, and covariate-adjusted Cox proportional hazard regression models were used to evaluate the relationship between metabolites and PC risk.

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  • Monoclonal antibody production is influenced by cellular and metabolic factors, making their understanding essential for optimizing manufacturing and increasing yields.
  • A novel strategy using quantitative proton nuclear magnetic resonance (H qNMR) technology helps identify key metabolites like glucose and lactate that impact bioprocess variability and cell growth.
  • The study reveals that maintaining optimal glucose levels and considering other critical variables can significantly enhance mAb yields, providing a basis for future improvements in bioprocess optimization.
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Background: Triglyceride-Glucose (TyG) index, a novel surrogate marker for insulin resistance, has been linked to the risk of various cancers, such as breast and colorectal cancers. However, the relationship between the TyG index and its related indices with the risk of pancreatic cancer(PC) remains unclear.

Methods: This large-scale, prospective cohort study utilized data from the UK Biobank, involving 428,152 participants who were free of PC at baseline.

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Background: Perampanel is a promising epilepsy treatment with an innovative mechanism of action. This study was performed to investigate the factors affecting perampanel clearance in a population pharmacokinetic (PPK) model of Chinese pediatric and adult patients with epilepsy.

Methods: A total of 135 perampanel plasma concentrations from 125 patients with epilepsy were analyzed using the PPK model with nonlinear mixed-effects modeling.

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  • Warehouses, especially food freezer ones, are vital for maintaining food quality but face challenges like item density and low temperatures.
  • Traditional management techniques fall short in addressing these issues, highlighting the need for smarter, digital solutions.
  • The YOLOv8-RSS model is introduced as a lightweight and accurate solution designed specifically for food freezer environments, featuring advanced detection enhancements and proven effectiveness in reducing computational demands while improving accuracy.
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Microplastic pollution in marine environments has become a global concern due to its potential ecological risks. However, long-term data on microplastic distribution are scare, hindering the assessment of the ecological threats. This study monitored microplastics pollution in the surface water of the northern South China Sea from 2019 to 2023.

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Mucosal immunity plays a critical role in the pathogenesis of inflammatory immune diseases. This study leverages single-cell RNA sequencing, spatial transcriptomics, and spatial proteomics to compare the cellular mechanisms involved in periodontitis between humans and mice, aiming to develop precise strategies to protect the gingival mucosal barrier. We identified key conserved and divergent features in cellular landscapes and transcriptional profiles across the two species, underscoring the complexity of inflammatory responses and immune dynamics in periodontitis.

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Introduction: The residential environment significantly impacts the mental health of older adults. Urban agglomeration planning, while fostering regional economic development, also influences the psychological well-being of this demographic.

Methods: This study investigates the effects of urban agglomeration planning on depression levels in older adults, utilizing cohort data from the China Health and Retirement Longitudinal Study (CHARLS) and the multi-temporal double-difference-in-differences (DID) model.

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  • Carbon emissions from land-use change have been a major contributor to global emissions, prompting the rise of low-carbon zoning governance as a critical approach for cities to mitigate climate change.
  • The study introduces a new theoretical framework for urban low-carbon governance that combines urban characteristics with spatial relationships, using China's Yangtze River Delta as a case study.
  • This framework categorizes cities into nine governance zones based on their attributes and network positions, offering a comprehensive approach that integrates socio-economic factors to enhance low-carbon planning and accelerate urban carbon neutrality.
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Background: Current guidelines support routine perioperative antibiotic prophylaxis (PAP) to minimize surgical site infection in kidney transplantation (KT), though data regarding the current practices of PAP is lacking in China.

Objective: To survey the routine PAP strategies in KT, and analyze main clinical considerations associated with adjusted antibiotic dosing regimens in different Chinese hospitals.

Methods: A nationwide survey was conducted on behalf of the National Alliance of Transplant Pharmacists.

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The purpose of study was to evaluate the predictive performance of models for the development of arrhythmias in patients with acute coronary syndrome after percutaneous coronary intervention. Two researchers screened the literature according to CHARMS, and assessed the risk of bias and applicability based on PROBAST. A total of 44 studies were included in the review, comprising 62 models, of which 30 models identified as having a low risk of bias, and only 7 studies combined other machine learning algorithms.

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This study investigates the function of a newly identified 127-amino acid peptide, circR-127aa, encoded by hsa_circ_0075402 (circRACK1), in gastric cancer (GC), a condition with significant prevalence in China. Utilizing a comprehensive analysis of circular RNA (circRNA) ribosome profiling data alongside experimental validations through mass spectrometry, Western blot, and immunofluorescence, we demonstrate that circR-127aa Inhibits Malignant Phenotypes and suppresses tumor growth in nude mice models. Significantly, the interaction of circR-127aa with Vimentin, a crucial element in actin-actin-cytoskeletal remodeling, indicates that circR-127aa functions as a tumor suppressor by facilitating the ubiquitination of Vimentin.

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  • * Research involving cytological experiments and bioinformatics revealed a poor prognosis for GC patients with EGFR overexpression, which also affects redox metabolism, increasing GSH levels and contributing to DDP resistance.
  • * A specific group of miRNAs (miR-135b, miR-106a, miR-29a, miR-23a, and miR-15a) was found to be upregulated in these
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The objective of this study was to explore the relationship between calf birth traits and their susceptibility to diseases before reaching adulthood. A total of 5253 birth traits of Chinese Holstein calves were examined, including gestation length (GL), calf weight at birth (CW), and calving ease score (CES), which ranges from 1 (easy) to 5 (very difficult). Furthermore, monthly medical records were scrutinized for pneumonia and diarrhea in these calves.

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A chemical investigation of the extracts from the soft coral led to the isolation and identification of four new meroterpenes, brassihydroxybenzoquinone A and B ( and ) and brassinaphthoquinone A and B ( and ), along with two known related meroterpenes ( and ). Their structures were elucidated using high-resolution electrospray ionization mass spectrometry (HRESIMS), nuclear magnetic resonance (NMR) spectroscopy, and a comparison with the literature data. All compounds were evaluated for antibacterial activity against six pathogenic bacterial strains and for cytotoxic activity against three cancer cell lines.

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Background: One-dimensional proton nuclear magnetic resonance (1D H NMR) spectroscopy is a non-destructive, non-targeted analytical technique providing both qualitative and quantitative insights, particularly beneficial for mixture analysis. However, the qualitative analysis of 1D H NMR spectra for mixture samples is laborious and time-consuming, involving extensive database searches and verification experiments like spiking. This process heavily relies on the analyst's expertise, leading to efficiency discrepancies.

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The average five-year survival rate for esophageal cancer, a common malignant tumor of the digestive system, is barely 20%. The majority of esophageal squamous cell carcinoma (ESCC) patients had already progressed to a locally advanced or even advanced stage at initial diagnosis, making routine surgery ineffective. Chemotherapy and immunotherapy are important neoadjuvant treatments for ESCC, however, it remains unknown how treatment will affect the immunological microenvironment, especially at the spatial level.

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  • * The research found that offspring of depressed mothers exhibited anxiety and depression-like behaviors, and the gut microbiota from these mothers played a significant role in this transmission.
  • * The findings highlight the importance of maternal mental health on children's emotional well-being and suggest that changing gut microbiota could be a potential treatment for childhood anxiety and depression.
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Introduction: The effective accumulation of nanoparticles (NPs) in the tumour area is an important goals of current nanotechnology research, and a targeted nanoplatform is an effective solution. So we designed a multifunctional sound-sensitive targeted NP that combines a sonosensitizer to enable precisely targeted, deep-penetration sonodynamic therapy (SDT) in combination with multimodal imaging for the diagnosis and monitoring of renal cell carcinoma (RCC).

Methods: ZnPP@PP NPs (ZnPP@PLGA- PFP NPs) were prepared via a double emulsion method, and G250 was covalently attached to the NPs shell via the carbon diimide method.

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As climate change, such as global warming, has become a global environmental issue, clarifying the mechanism driving the carbon budget based on land use change has become an inevitable path to realize the "double carbon" goal. Based on the land use change characteristics in the Hangzhou Metropolitan Area from 1995 to 2020, this study employed the inventory accounting method, concentration index, and panel regression models to investigate the driving mechanisms of carbon budget dynamics influenced by land use changes. Moreover, the study utilized a "scenario-actor" policy analysis framework to propose low-carbon strategies through the integration of land use management within territorial spatial planning.

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  • Decision fatigue is when people get tired of making decisions, which can make it hard for nurses to do their job well, especially during tough times like the COVID-19 pandemic.
  • A study with 14 nurses showed that decision fatigue has three main themes: how it affects their thinking and feelings, what causes it, and ways to avoid it.
  • The study found that decision fatigue is common among nurses and negatively impacts their health and patient care, and more education about decision fatigue is needed for nurses.
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In the context of global aging, promoting the health of the elderly has become a critical issue. However, whether the development of smart cities can impact the health of older adults remains to be further validated. In this paper, based on panel data from the China Health and Retirement Longitudinal Study (CHARLS), a difference in difference model is used to empirically investigate whether smart city construction improves the health of older people in the region.

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Clarifying the mechanism of influence of urban form on carbon emissions is an important prerequisite for achieving urban carbon emission reduction. Taking the Yangtze River Economic Belt as an example, this study elaborated on the general mechanism of urban form on carbon emissions, used multi-source data to quantitatively evaluate the urban form, and explored the impacts of urban form indicators on carbon emissions from 2005 to 2020 at global and sub-regional scales with the help of spatial econometric models and geodetector, respectively. The results showed that:① The carbon emissions of the Yangtze River Economic Belt increased from 2 365.

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Synopsis of recent research by authors named "Jiayu Yang"

  • - Jiayu Yang's recent research spans various interdisciplinary areas including oncology, animal health, marine chemistry, environmental science, and public health.
  • - Key findings highlight the mechanisms of chemoresistance in gastric cancer, the influence of birth traits on calf disease susceptibility, and the role of gut microbiota in transmitting anxiety and depression-like behaviors in rats.
  • - Yang's studies also explored innovative therapeutic approaches, such as targeted nanoplatforms for renal cell carcinoma treatment, and the impact of smart city development on the health of elderly populations, indicating a focus on both health-related outcomes and environmental factors.

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