Analysis of Microbial Community Heterogeneity and Carbon Fixation Capabilities in Oil-Contaminated Soils in Chinese Onshore Oilfields.

This study selected 27 soil samples from four representative horizontally distributed onshore oilfields in China to explore the diversity of soil microbial communities and their carbon fixation capacity, with a focus on the potential interaction between pollution and carbon fixation under oil pollution stress. The analysis of the soil physicochemical properties and microbial community structures from these oilfield samples confirmed a clear biogeographic isolation effect, indicating spatial heterogeneity in the microbial communities. Additionally, the key factors influencing microbial community composition differed across regions.

Gemcitabine plus cisplatin versus docetaxel plus cisplatin and fluorouracil induction chemotherapy combined with locoregional radiotherapy in de novo metastatic nasopharyngeal carcinoma: A single center prospective phase II clinical trial.

Purpose: This prospective clinical trial aims to compare the efficacy and safety of gemcitabine plus cisplatin (GP) versus docetaxel plus cisplatin and fluorouracil (TPF) as induction chemotherapy combined with locoregional radiotherapy in de novo metastatic nasopharyngeal carcinoma (dmNPC).

Methods: 146 dmNPC patients were randomly assigned in a 1:1 ratio to receive 4-6 cycles of GP (GP group) or TPF induction chemotherapy (TPF group) followed by locoregional radiotherapy (LRRT). The primary endpoint was overall survival (OS).

Ascending aortic length predicts adverse outcomes in type A intramural haematoma.

Objectives: Ascending aortic length has recently been recognized as a novel predictor of adverse events in aortic diseases, but its prognostic value in type A intramural haematoma is unknown. We aimed to evaluate the association between ascending aortic length and outcomes in patients with type A intramural haematoma initially managed medically.

Methods: We retrospectively analysed patients with acute type A intramural haematoma.

Preparation of biochar/iron mineral composites and their adsorption of methyl orange.

Biochar-supported iron-containing minerals have received much attention due to their synergistic mechanism of decontamination in environmental pollution remediation. In this work, two types of iron/biochar were prepared from different biomasses using ferric chloride as the Fe source and rice husks and peanut shell as biomasses. The formation of fayalite (FeSiO) and magnetite (FeO) in rice husk and peanut shell derived biochar was proved by X-ray diffraction.

Sustainable Water Management with Photocatalytic Janus Mesh: Efficient Fog Harvesting, Water Purification, and Microbial Disinfection.

Water scarcity is a critical global challenge, especially in arid and semiarid regions. Fog harvesting has emerged as a promising solution; however, concerns about air pollution and bacterial growth in humid environments have raised doubts about the safety and sustainability of such systems. This study introduces a Janus mesh with asymmetric wettability on its two faces, fabricated through a simple and scalable method.

METTL3 governs thymocyte development and thymic involution by regulating ferroptosis.

Given its central role in immune aging, it is important to identify the regulators of thymic involution. While conventional programmed cell death has a fundamental role in thymocyte development, how cell death pathways contribute to thymic involution are unclear. In this study, we found that CD4CD8 double-positive (DP) thymocytes acquired the characteristics of senescence in aged mice undergoing thymic involution, while expression of the mA methyltransferase-like protein 3 (METTL3), which is enriched in DP cells from young mice, decreased with aging.

Occurrences, source apportionment, and potential risks of 55 progestins in surface water of the Yellow River Delta, China.

Progestins (PGs) are a group of emerging contaminants with endocrine disrupting effects. Despite their large amounts of use and excretion, investigations have been limited to several compounds in the aqueous phase, and the occurrences and distribution of numerous PGs in different matrices remain unclear. In this study, water, suspended particulate matter and sediment samples from rivers in the Yellow River Delta (YRD), China were investigated over two seasons to elucidate the occurrences, sources, and ecological risks of 55 natural and synthetic PGs.

Organochlorine pesticides and polychlorinated biphenyls in sediments of the Lanzhou reach of Yellow River (China): Spatial distribution, sources and risk assessment.

Knowledge about sediment levels and sources of persistent organic pollutants (POPs) in Lanzhou section Yellow River remains limited. Organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) levels in 12 sediment samples from this region were measured by GC/MS. OCPs concentrations ranged from 85.

RNF113A as a poor prognostic factor promotes metastasis and invasion of cervical cancer through miR197/PRP19/P38MAPK signaling pathway.

It has been discovered that aberrant expression of RNF113A plays a significant role in various diseases, including esophageal cancer, hepatocellular carcinoma, and X-linked trichothiodystrophy syndrome. Nevertheless, its functional implications in cervical cancer (CC) remain unclear. The objective of this study was to investigate the role of RNF113A in both the development and prognosis of CC.

Survival strategies and assembly mechanisms of microbial communities in petroleum-contaminated soils.

This study analyzed petroleum-contaminated soils from south and north locations in China to explore the structure, diversity, functional genes and assembly processes of microbial communities' . Compared with soils from south locations, soils from northern regions exhibited elevated pH, total nitrogen (TN), and total petroleum hydrocarbon (TPH) levels. Among these, TN and TPH were the most influential on the microbial community.

Computed Tomography Imaging Guided Microenvironment-Responsive Ir@WO Dual-Catalytic Nanoreactor for Selective Radiosensitization.

Radiotherapy (RT) is often administered, either alone or in combination with other therapies, for most malignancies. However, the degree of tumor oxygenation, damage to adjacent healthy tissues, and inaccurate guidance remain issues that result in discontinuation or failure of RT. Here, a multifunctional therapeutic platform based on Ir@WO is developed which simultaneously addresses these critical issues above for precision radiosensitization.

Tumor Cell-Targeting and Tumor Microenvironment-Responsive Nanoplatforms for the Multimodal Imaging-Guided Photodynamic/Photothermal/Chemodynamic Treatment of Cervical Cancer.

Purpose: Phototherapy, known for its high selectivity, few side effects, strong controllability, and synergistic enhancement of combined treatments, is widely used in treating diseases like cervical cancer.

Methods: In this study, hollow mesoporous manganese dioxide was used as a carrier to construct positively charged, poly(allylamine hydrochloride)-modified nanoparticles (NPs). The NP was efficiently loaded with the photosensitizer indocyanine green (ICG) via the addition of hydrogen phosphate ions to produce a counterion aggregation effect.

Carbon Dots Anchoring Single-Atom Pt on CN Boosting Photocatalytic Hydrogen Evolution.

Carbon nitride (CN) has gained considerable attention and has been regarded as an ideal candidate for photocatalytic hydrogen evolution. However, its photocatalytic efficiency is still unsatisfactory due to the rapid recombination rate of photo-generated carriers and restricted surface area with few active sites. Herein, we successfully synthesized a single-atom Pt cocatalyst-loaded photocatalyst by utilizing the anchoring effect of carbon dots (CDs) on CN.

COAP-Pd Catalyzed Asymmetric Formal [3+2] Cycloaddition for Optically Active Multistereogenic Spiro Cyclopentane-Indandiones Bearing Cyclic N-Sulfonyl Ketimine Skeletons.

We reported a chiral oxamide-phosphine ligand (COAP-Ph)-Pd-catalyzed asymmetric [3+2] cycloaddition reaction between vinyl cyclopropane compounds derived from 1,3-indanedione and 2-vinylcyclopropane-1,1-dicarboxylates with cyclic sulfonyl 1-azadienes. The corresponding reactions provided a series of enantiomerically active spiro cyclopentane-indandione and cyclopentane structures bearing three consecutive stereogenic centers in good yields with good diastereo- and enantioselectivity. The COAP-Pd complex serves not only to promote generation of chiral π-allyl-palladium intermediates and induce the asymmetry of the reaction, but also depress the background reaction.

Analysis of the current state of cervical cancer prevention awareness and its influencing factors among rural women in Luohe City.

The purpose of this cross-sectional study was to identify the current awareness about cervical cancer prevention among rural women in Luohe City as well as its potential influencing factors. Meanwhile, these data were expected to provide a theoretical basis for Luohe future cervical cancer prevention and therapy. Based on geographical distribution, 40 villages in Luohe City were randomly selected, and questionnaires were given to women in each village.

Calcium-sensing receptor alleviates gut damage caused by endotoxemia by regulating gut microbiota.

Background: Growing evidence points to an association between the gut microbiota and neonatal diseases. Calcium-sensing receptor (CaSR) is a major modulator of tissue responses associated with calcium homeostasis and is highly expressed in the mammalian gut. CaSR may affect the composition and balance of the intestinal microenvironment.

The intricate role of annexin A2 in kidney: a comprehensive review.

Annexin A2 (Anxa2) is a calcium (Ca)-regulated phospholipid binding protein composed of a variable N-terminus and a conserved core domain. This protein has been widely found in many tissues and fluids, including tubule cells, glomerular epithelial cells, renal vessels, and urine. In acute kidney injury, the expression level of this protein is markedly elevated in response to acute stress.

Integrated analysis of transcriptome and metabolome reveals insights for low-temperature germination in hybrid rapeseeds (Brassica napus L.).

Rapeseed (Brassica napus L.) is an important oil-producing crop in China. However, cold stress in winter can adversely affect rapeseed germination and subsequently result in poor seed yield at the mature stage.

Vitexin attenuates chronic kidney disease by inhibiting renal tubular epithelial cell ferroptosis via NRF2 activation.

Background: Chronic kidney disease (CKD) involves a variety of pathological processes, and ferroptosis plays a vital role in CKD progression. Targeting ferroptosis is a promising strategy for the treatment of CKD. However, inhibitors of ferroptosis have not been used in the clinical treatment of CKD.

Calcium-Sensitive Receptors Alters Intestinal Microbiota Metabolites Especially SCFAs and Ameliorates Intestinal Barrier Damage in Neonatal Rat Endotoxemia.

Purpose: The calcium-sensing receptor (CaSR) acts as a major modulator of tissue responses related to calcium homeostasis and expresses highly in the mammalian intestine. Endotoxemia tends to impair intestinal barrier function and poses significant obstacles in clinical treatment. This work is designed to decipher whether CaSR can protect lipopolysaccharide (LPS)-induced intestinal barrier dysfunction in neonatal rats by targeting intestinal metabolites.

SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of 4-butyl-polyhydroxybenzophenone compounds against NAFLD.

The mitochondria have been identified as key targets in nonalcoholic fatty liver disease (NAFLD), one of the most prevalent chronic liver damage diseases globally. Meanwhile, the biological information analysis in this study revealed that SIRT1, PPARG, PPARA, and PPARGC1A (mitochondrial biogenesis-related proteins) were NAFLD therapeutic targets. Therefore, the design and synthesis of targeted drugs that promote mitochondrial biogenesis and improve mitochondrial function are particularly important for NAFLD treatment.