Discovery of Novel Small-Molecule Inhibitors Disrupting the MTDH-SND1 Protein-Protein Interaction.

MTDH-SND1 protein-protein interaction (PPI) plays an important role in the initiation and development of tumors, and it is a target for the treatment of breast cancer. In this study, we identified and synthesized a series of novel small-molecule inhibitors of MTDH-SND1 PPI. The representative compound showed potent activity against MTDH-SND1 PPI with an IC of 487 ± 99 nM and tight binding to the SND1-purified protein with a value of 279 ± 17 nM.

Towards real-time myocardial infarction diagnosis: a convergence of machine learning and ion-exchange membrane technologies leveraging miRNA signatures.

Rapid diagnosis of acute myocardial infarction (AMI) is crucial for optimal patient management. Accurate diagnosis and time of onset of an acute event can influence treatment plans, such as percutaneous coronary intervention (PCI). PCI is most beneficial within 3 hours of AMI onset.

Effect evaluation of decentralized domestic sewage treatment facilities in rural areas - a case study of Nantong City, China.

Rural domestic sewage has the characteristics of large and scattered discharge, as well as complex components; thus, how to effectively and efficiently manage rural domestic sewage is a big challenge for policy makers. Current decentralized domestic sewage treatment facilities (DDSTF) involve different treatment processes and power drive modes; at the same time, the treatment effect is also affected by a variety of local factors. However, there is a lack of research to explore the implementation performance of the DDSTF from a comprehensive perspective.

Gene liposome nanocomplex-loaded dermal substitute promotes diabetic chronic wound healing and angiogenesis in rat.

The incidence of chronic diabetic wounds is increasing with the growing number of diabetic patients, and conventional wound dressings have proven to be ineffective in treating them. To address this challenge, researchers have developed artificial dermal substitutes using collagen and hyaluronic acid, which are crucial extracellular matrices. However, these subsitiues lack precision and targeted treatment.

High-resolution mapping of the rainfall runoff pollution: case study of Shiwuli River watershed, China.

Rainfall runoff is the key factor of water quality deterioration in highly urbanized area, which is characterized by intensive human activities and frequent extreme weather events. Urban landscape system is composed of highly diverse and heterogeneous land patches, which makes the effective management of urban runoff pollution difficult. Therefore, high-resolution land-use data is imperative for the identification and analysis of spatial-temporal characteristics of urban runoff pollution.

One-Pot Rapid Access to Benzyl Silanes, Germanes, and Stannanes from Toluenes Mediated by a LiN(SiMe)/CsCl System.

Organo-silanes, germanes, and stannanes are considered to be conducive to the development of cross-coupling reactions because they are stable, nontoxic, and easy to handle. Using feedstock toluenes, one-pot direct benzylic C-H silylations, germylations, and stannylations are developed. Simply combining toluenes, LiN(SiMe)/CsCl, and RMCl (M = Si, Ge, Sn) generates a diverse array of bench-stable benzyl silanes, germanes, and stannanes (38 examples, 53-90% yields).

Efficiency of Multifunctional Antibacterial Hydrogels for Chronic Wound Healing in Diabetes: A Comprehensive Review.

Diabetic chronic wounds or amputation, which are complications of diabetes mellitus (DM), are a cause of great suffering for diabetics. In addition to the lack of oxygen, elevated reactive oxygen species (ROS) and reduced vascularization, microbial invasion is also a critical factor that induces non-healing chronic diabetic wounds, ie, wounds still remaining in the stage of inflammation, after which the wound tissue begins to age and becomes necrotic. To clear up the infection, alleviate the inflammation in the wound and prevent necrosis, many kinds of hydrogel have been fabricated to eliminate infections with pathogens.

Cardiac Cell Patterning on Customized Microelectrode Arrays for Electrophysiological Recordings.

Cardiomyocytes (CMs) and fibroblast cells are two essential elements for cardiac tissue structure and function. The interactions between them can alter cardiac electrophysiology and thus contribute to cardiac diseases, such as arrhythmogenesis. One possible explanation is that fibroblasts can directly affect cardiac electrophysiology through electrical coupling with CMs.

Structural configuration and tetragonal phase stability in the equiatomic quaternary Heusler compound TiZnMnSi.

Heusler materials have aroused great scientific research interest during recent years due to their special electronic and magnetic properties. Especially for the equiatomic quaternary Heusler compounds, they exhibit very high composition flexibility and structure tunability. In this work, we have carried out a systematic study on the structural configuration and tetragonal stability for the Heusler compound TiZnMnSi by first-principles calculations.

Animal based diets and environment: Perspective from phosphorus flow quantifications of livestock and poultry raising in China.

Identifying the key nodes of the phosphorus flows in animal raising system is fundamental to improve P utilization efficiency and reduce the P contamination. This study established a phosphorus flow analysis model for livestock and poultry raising, depicted P flows for major livestock and poultry under two raising modes, and further analyzed their spatial and temporal distributions. We find that around 15% of P input was transferred into the products, and in P output around 40% lost into the environment in 2015.