Comparison of efficacy and safety between gonioscopy-assisted transluminal trabeculotomy and trabeculectomy for primary open-angle glaucoma treatment: a retrospective cohort study.

Background: Trabeculectomy (TRAB) traditionally has been the gold-standard surgical treatment for primary open-angle glaucoma (POAG), while gonioscopy-assisted transluminal trabeculotomy (GATT) is an emerging minimally invasive surgery used for the treatment of various open-angle glaucoma (OAG) types. In this study, we aimed to compare the efficacy and safety between GATT and TRAB for the treatment of POAG.

Methods: This cohort study included eyes with POAG that underwent a single GATT (30 eyes) or TRAB (34 eyes).

Density Functional Theory Provides Insights into β-SnSe Monolayers as a Highly Sensitive and Recoverable Ozone Sensing Material.

This study explores the potential of β-SnSe monolayers as a promising material for ozone (O) sensing using density functional theory (DFT) combined with the non-equilibrium Green's function (NEGF) method. The adsorption characteristics of O molecules on the β-SnSe monolayer surface were thoroughly investigated, including adsorption energy, band structure, density of states (DOSs), differential charge density, and Bader charge analysis. Post-adsorption, hybridization energy levels were introduced into the system, leading to a reduced band gap and increased electrical conductivity.

Extra cut-off value of aldosterone-to-renin ratio for screening primary aldosteronism in hypertensive patients with diabetes mellitus.

Primary aldosteronism (PA) and diabetes mellitus (DM) may coexist. We previously found that DM and impaired glucose tolerance (IGT) may decrease the efficiency of the aldosterone-to-renin ratio (ARR) for screening PA. Thus, we wanted to determine appropriate ARR cut-off values for screening PA in patients with hypertension with DM and IGT.

Microstructure and molten pool morphology of TiB/ AlSi7Mg composites fabricated by infrared-blue hybrid laser powder bed fusion.

A hybrid laser composed of infrared and blue laser is applied in fabricating TiB/AlSi7Mg composites on AlSi7Mg substrate by LPBF. The effect on formability, molten pool morphology, molten pool size and microstructure under infrared, blue and hybrid laser were compared. It was confirmed that hybrid laser can make up for the unbalanced energy distribution of infrared laser and the low energy density of blue laser.

CXCL16 exacerbates Pseudomonas aeruginosa keratitis by promoting neutrophil activation.

Pseudomonas aeruginosa (PA) keratitis is a major cause of blindness characterized by corneal inflammation. In a murine model of PA keratitis, we assessed the detrimental effects of CXC chemokine ligand 16 (CXCL16). Quantitative PCR (qPCR), western blotting (WB) and immunofluorescence were used to measure the expression and localization of CXCL16 and its receptor, CXC chemokine receptor 6 (CXCR6).

Intraocular lens power calculation for silicone oil-dependent eyes.

Background: Silicone oil tamponade is widely used in vitreoretinal surgery. In some cases, silicone oil may not be extracted for a long time or even permanently and is referred to as silicone oil-dependent eyes. In this study, we aimed to deduce a theoretical formula for calculating intraocular lens power for silicone oil-dependent eyes and compare it with clinical findings.

A DFT Study of Volatile Organic Compounds Detection on Pristine and Pt-Decorated SnS Monolayers.

Real-time monitoring of volatile organic compounds (VOCs) is crucial for both industrial production and daily life. However, the non-reactive nature of VOCs and their low concentrations pose a significant challenge for developing sensors. In this study, we investigated the adsorption behaviors of typical VOCs (CH, CH, and CH), on pristine and Pt-decorated SnS monolayers using density functional theory (DFT) calculations.

Excess Deaths of Gastrointestinal, Liver, and Pancreatic Diseases During the COVID-19 Pandemic in the United States.

To evaluate excess deaths of gastrointestinal, liver, and pancreatic diseases in the United States during the COVID-19 pandemic. We retrieved weekly death counts from National Vital Statistics System and fitted them with a quasi-Poisson regression model. Cause-specific excess deaths were calculated by the difference between observed and expected deaths with adjustment for temporal trend and seasonality.

Plant-inspired multifunctional fluorescent cellulose nanocrystals intelligent nanocomposite hydrogel.

Intelligent hydrogel has great application potentials in flexible sensing and artificial intelligence devices due to its intrinsic characteristics. However, developing an intelligent hydrogel with favorable properties including high strength, superior toughness, excellent conductivity and ionic sensing via a facile route is still a challenge. Herein, inspired by biologically chelating interactions of phytic acid (PA) in plants, a plant-inspired versatile intelligent nanocomposite hydrogel was readily fabricated by incorporating PA into the interface of fluorescent cellulose nanocrystals (F-CNC).

Photoelectrochemical biosensor based on SiW@CdS quantum dots for the highly sensitive detection of HPV 16 DNA.

A highly sensitive biosensor for detecting HPV 16 DNA was prepared based on Keggin-type polyoxometalate (SiW)-grafted CdS quantum dots (SiW@CdS QDs) and colloidal gold nanoparticles (Au NPs), which exhibited remarkable selectivity and sensitivity upon target DNA detection because of its excellent photoelectrochemical (PEC) response. Here, an enhanced photoelectronic response ability was achieved with the strong association of SiW@CdS QDs by polyoxometalate modification, which was developed through a convenient hydrothermal process. Furthermore, on Au NP-modified indium tin oxide slides, a multiple-site tripodal DNA walker sensing platform coupled with T7 exonuclease was successfully fabricated with SiW@CdS QDs/NP DNA as a probe for detecting HPV 16 DNA.

Protective effects of resolvin D1 in Pseudomonas aeruginosa keratitis.

Purpose: Here, we explored the protective effects of resolvin D1 (RvD1) in Pseudomonas aeruginosa (PA) keratitis.

Methods: C57BL/6 (B6) mice were used as an animal model of PA keratitis. Plate counting and clinical scores were used to assess the severity of the infection and the therapeutic effects of RvD1 in the model.

Accelerate wound healing by microscale gel array patch encapsulating defined SDF-1α gradient.

Recruiting endogenous stem cells to deliver signaling molecules is an attractive therapeutic strategy for the treatment of skin injuries. Although various signaling molecule delivery techniques have been developed, they are limited in their ability to accurately mimic the natural physiological process in which stem cells are recruited via signaling molecule concentration gradients. Hence, herein, we developed an approach to generate persistent signaling molecule concentration gradients in microscale gel arrays.

The risk factors for Group B Streptococcus colonization during pregnancy and influences of intrapartum antibiotic prophylaxis on maternal and neonatal outcomes.

Background: Group B Streptococcus (GBS), also referred as Streptococcus agalactiae, is one of the leading causes of life-threatening invasive diseases such as bacteremia, meningitis, pneumonia and urinary tract infection in pregnant women and neonates. Rates of GBS colonization vary by regions, but large-sample studies on maternal GBS status are limited in southern China. As a result, the prevalence of GBS among pregnant women and its associated risk factors and the efficacy of intrapartum antibiotic prophylaxis (IAP) intervention in preventing adverse pregnancy and neonatal outcomes remain poorly understood in southern China.

A longitudinal study on college students' depressive symptoms during the COVID-19 pandemic: The trajectories, antecedents, and outcomes.

The ongoing COVID-19 pandemic is not only an immediate hazard but also a long-term risk to the development of depressive symptoms. However, it remains unclear how people's depressive symptoms change with the process of COVID-19. Further, there is also a paucity of research on the underlying antecedents and outcomes of depressive symptoms during this global health crisis.

Zirconium Phosphate Assisted Phosphoric Acid Co-Catalyzed Hydrolysis of Lignocellulose for Enhanced Extraction of Nanocellulose.

The high mechanical strength, large specific surface area, favorable biocompatibility, and degradability of nanocellulose (CNC) enable it to be a potential alternative to petroleum-based materials. However, the traditional preparation of CNCs requires a large amount of strong acid, which poses a serious challenge to equipment maintenance, waste liquid recycling, and economics. In this study, a solid and easily recoverable zirconium phosphate (ZrP) was used to assist in the phosphoric acid co-catalyzed hydrolysis of lignocellulose for extracting CNCs.

Evaluation of the Rapid Antigen Detection Test for Diagnosing SARS-CoV-2 during the COVID-19 Pandemic: Experience from a Centralized Isolation Site in Shanghai, China.

Rapid and reliable diagnosis is important for the management of individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The rapid antigen detection test (RADT) is a rapid, inexpensive, and easy method. Several studies have reported that RADTs performed well in many countries; however, very few studies have been reported in China.

Controllable Construction of Temperature-Sensitive Supramolecular Hydrogel Based on Cellulose and Cyclodextrin.

In temperature sensitive hydrogels, the swelling degree or light transmittance of the gel itself changes with variations in ambient temperature, prompting its wide application in controlled drug release, tissue engineering, and material separation. Considering the amphiphilic structure of β-cyclodextrin (β-CD), a cellulose-based supramolecular hydrogel with superior temperature sensitivity was synthesized based on a combination of cellulose and β-CD as well as the host-guest interaction between β-CD and polypropylene glycol (PPG). In the one-pot tandem reaction process, chemical grafting of β-CD on cellulose and the inclusion complexation of β-CD with PPG were performed simultaneously in a NaOH/urea/water system.

Passivator-Free Microwave-Hydrothermal Synthesis of High Quantum Yield Carbon Dots for All-Carbon Fluorescent Nanocomposite Films.

Based on the self-passivation function of chitosan, an efficient, and green synthesis strategy was applied to prepare chitosan carbon dots (CDs). The quantum yield of carbon dots reached 35% under the conditions of hydrothermal temperature of 200 °C, hydrothermal time of 5 h, and chitosan concentration of 2%. Moreover, the obtained carbon dots had high selectivity and sensitivity to Fe.

One-Pot Synthesis of UPy-Functionalized Nanocellulose under Mechanochemical Synergy for High-Performance Epoxy Nanocomposites.

The high strength, high specific surface area, excellent biocompatibility, and degradability of nanocellulose (NCC) make it a potential reinforcing phase for composite materials. However, the polyhydroxyl property of NCC renders it prone to self-aggregation and it has weak interfacial compatibility with non-polar substrates, limiting its enhancement performance for composite materials. Therefore, based on the high reactivity of NCC, the chemical modification of NCC to introduce functional groups is the basis for effectively reducing its self-aggregation, improving its interfacial compatibility with the polymer matrix, and creating nanocellulose-based functional materials.

One-Pot Green Preparation of Fluorescent Cellulose Nanofibers.

Fluorescent cellulose nanofibers (FCNFs), with a high yield, were prepared via one-pot hydrolysis and the grafting reaction of cellulose with thiazolipyridine carboxylic acid (TPCA). The hydrolysis and Fischer esterification of cellulose were conducted under microwave-hydrothermal conditions; meanwhile, TPCA formation was induced by the dehydration reaction between L-cysteine and citric acid. The effects of the reaction temperature and reaction time on the yield and performance of FCNF were investigated.

Interactions of thymic stromal lymphopoietin with interleukin-4 in adaptive immunity during keratitis.

Aim: To investigate the potential interactions of thymic stromal lymphopoietin (TSLP) with interleukin-4 (IL-4) in adaptive immunity during fungal keratitis (FK).

Methods: An FK mouse model was induced with (AF) hyphal infection. Mice were divided into several groups: untreated, phosphate buffer saline (PBS), infected with AF, and pretreated with a scrambled siRNA, a TSLP-specific siRNA (TSLP siRNA), murine recombinant TSLP (rTSLP), immunoglobulin G (IgG), murine recombinant IFN (rIFN-γ), murine recombinant IL-4 (rIL-4), rIL-13, murine recombinant IL-17A (rIL-17A), and murine recombinant IL-17F (rIL-17F) groups.

Vortices-interaction-induced microstreaming for the pump-free separation of particles.

Microfluidic techniques have emerged as promising strategies for a wide variety of synthetic or biological sorting. Unfortunately, there is still a lack of sorting with automatic and handy operation. In contrast to passively generated vortices, the thermocapillary vortices produced by temperature gradient have the advantages of flexible manipulation, stable strength, and simple integration.

Thymic stromal lymphopoietin participates in the TLR2-and TLR4-dependent immune response triggered by Aspergillus fumigatus in human corneal cells.

Fungal keratitis constitutes a serious vision-threatening disease. Toll-like receptors (TLRs) comprise key mediators of innate immunity triggered by Aspergillus fumigatus (AF) in the cornea, but the messenger between innate and adaptive immunity remained unknown. Thymic stromal lymphopoietin (TSLP) represents a critical factor of adaptive immunity.