Publications by authors named "Jiayi Peng"

Purpose: Fertility preservation (FP) is a critical concern for young breast cancer (YBC) patients receiving gonadotoxic treatments. Breast surgical healthcare providers (HCPs) play a pivotal role in discussing FP options and facilitating timely referrals. This study aimed to assess the knowledge, attitudes, and practices of breast surgical HCPs in China regarding FP, identify barriers to FP discussions, and examine factors influencing referral practices.

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Thermoelectrics can mutually convert between thermal and electrical energy, ensuring its utilization in both power generation and solid-state cooling. BiTe exhibits promising room-temperature performance, making it the sole commercially available thermoelectrics to date. Guided by the lattice plainification strategy, we introduce trace amounts of Cu into n-type Bi(Te, Se) (BTS) to occupy Bi vacancies, thereby simultaneously weakening defect scattering and modulating the electronic bands.

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The widespread accumulation of androgenic steroid endocrine disruptors in water and food has garnered increasing attention due to their significant risks to ecosystems and human health. These steroids, which cannot be completely eliminated, highlight the urgent need for advanced detection technologies. In this study, we present a novel emulsion-induced interface-anisotropic assembly strategy to synthesize bowl-like mesoporous polydopamine (PDA) particles, which exhibit high sensitivity in surface-enhanced Raman scattering (SERS) detection.

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Background: Cutaneous Mycobacterium marinum (M. marinum) infection can lead to the formation of infectious granulomas containing Langhans giant cells (LGCs). Due to concerns about prolonged antibiotic use and the development of drug resistance, its treatment poses challenges.

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The strain data acquired from structural health monitoring (SHM) systems of large-span bridges are often contaminated by a mixture of temperature-induced and vehicle-induced strain components, thereby complicating the assessment of bridge health. Existing approaches for isolating temperature-induced strains predominantly rely on statistical temperature-strain models, which can be significantly influenced by arbitrarily chosen parameters, thereby undermining the accuracy of the results. Additionally, signal processing techniques, including empirical mode decomposition (EMD) and others, frequently yield unstable outcomes when confronted with nonlinear strain signals.

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  • Gain-of-function (GOF) variants enhance or change protein functions and are crucial for understanding diseases, but identifying them is tough due to scattered data and limited databases.
  • The authors reviewed existing research to gather 3089 single-nucleotide variants and 72 small insertions/deletions across 579 genes linked to 1299 diseases, combining this with 3.5 million predicted GOF variants and employing a custom scoring system to rank their significance.
  • They created GoFCards, a user-friendly database that allows geneticists and clinicians to easily access and analyze GOF variants, providing extensive annotations and the ability to prioritize variants even for those with limited bioinformatics experience.
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  • - A 57-year-old healthy Canadian man developed severe invasive group A Streptococcus (GAS) diseases like necrotizing fasciitis and myositis after hiking in the Gobi Desert, leading to Streptococcal Toxic Shock-Like Syndrome (STSS).
  • - Despite comprehensive treatment, including antimicrobial therapy and surgery, he ultimately required amputation of his right leg but managed to recover after 43 days in the hospital.
  • - Whole-genome sequencing revealed the presence of 15 virulence factors in the strain and highlighted the need for early detection and intervention for invasive GAS infections, particularly the concerning 22/ST46 variant in China.
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Background: Pituitary adenomas (PAs) are the second most common intracranial tumor. While current diagnostic practices rely primarily on histological testing, they often fail to capture the molecular complexities of pituitary adenomas, underscoring the need for a molecular-based classification to refine therapeutic strategies and prognostic assessments. This study aims to provide a molecularly unbiased classification of pituitary adenomas and explore their unique gene expression patterns and clinical features.

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The development of an affordable, portable, and instrument-free colorimetric biosensor holds significant importance for routine monitoring and clinical diagnosis. To overcome the limitations that traditional monochromatic colorimetric kits struggle to distinguish subtle color changes with the naked eye, we designed and constructed a portable hydrogel kit for polychromatic semi-quantitative and quantitative sensing analysis. When the actual samples and I- were introduced into a gelatin hydrogel encapsulated with MIL-88A(Fe), Au NRs and oxidase (Au@GM88A/I), a noticeable color change occurred.

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Background: The COVID-19 pandemic, caused by the novel coronavirus, has had a profound impact on global health and economies worldwide. This unprecedented crisis has affected individuals, communities, and nations in diverse manners. Developing simple and accurate diagnostic methods is an imperative task for frequent testing to mitigate the spread of the virus.

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  • Fusarium wilt is a bad disease for banana plants caused by a fungus called Fusarium oxysporum f. sp. cubense (Foc).
  • Scientists changed a gene called FoAce2 in the fungus to see how it affects the fungus's ability to make bananas sick.
  • Without this gene, the fungus grew slower, had thicker cell walls, and was much less harmful to bananas, showing that FoAce2 is really important for the fungus to be strong and grow properly.
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  • The study investigates how gestational weight gain (GWG) affects the timing of lactogenesis II (DOL II), which is when mammals start producing mature breast milk after giving birth.
  • It analyzes data from 16 articles, encompassing over 248,000 women, finding that excessive GWG increases the risk of delayed lactogenesis II, especially in overweight, obese, and underweight women who gained too much weight.
  • Additionally, women with excessive GWG are likely to stop exclusive breastfeeding within one month after giving birth, indicating a negative impact of high GWG on breastfeeding practices.
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With the public heightened emphasis on mitigating the occurrence risks of health-related ailment and optimizing personal physical performance, portable chemical sensing devices emerged as an indispensable component of pervasive health monitoring. Chemical sensing enabled the immediate and on-site identification of biomarkers in biological fluids by integrating colorimetry, fluorescence, electrochemical, and other methods into portable sensor devices. These sensor devices incorporated microneedles, hydrogels, microfluidic modules, and papers, facilitating conformal human-device contact and providing several visual sensing options for disease prevention and healthcare management.

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Background: We investigated the presence of Chlamydia psittaci in poultry and the environment in live poultry wholesale markets in Changsha during 2021-2022 and conducted a phylogenetic analysis to understand its distribution in this market.

Methods: In total, 483 samples were analyzed using real-time polymerase chain reaction and 17 C. psittaci-positive samples using high-throughput sequencing, BLAST similarity, and phylogenetic analysis.

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Introduction And Hypothesis: Catheterization is a common treatment for postpartum urinary retention (PUR); however, its application before diagnosis of PUR remains unclear. The aim was to give an overview of the existing literature on the effectiveness and safety of intrapartum or postpartum catheterization in the prevention of PUR.

Methods: This scoping review followed a methodological framework.

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  • Head and neck squamous cell carcinoma (HNSCC) is a common and aggressive cancer with low survival rates, emphasizing the need for new treatment targets.
  • * Integrin αV (ITGAV) is found to be upregulated in HNSCC, with higher levels linked to poorer survival outcomes and greater invasiveness in specific cancer cell lines.
  • * The study highlights that ITGAV plays a key role in the spread of HNSCC cells, and its expression may be controlled by the SOX11 protein.
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The accumulation of unfolded or misfolded proteins within the endoplasmic reticulum (ER), due to genetic determinants and extrinsic environmental factors, leads to endoplasmic reticulum stress (ER stress). As ER stress ensues, the unfolded protein response (UPR), comprising three signaling pathways-inositol-requiring enzyme 1, protein kinase R-like endoplasmic reticulum kinase, and activating transcription factor 6 promptly activates to enhance the ER's protein-folding capacity and restore ER homeostasis. However, prolonged ER stress levels propels the UPR towards cellular demise and the subsequent inflammatory cascade, contributing to the development of human diseases, including cancer, neurodegenerative disorders, and diabetes.

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  • High-resolution SNP arrays were utilized to identify copy number variations (CNVs) in fetuses diagnosed with congenital heart defects (CHDs), revealing a link between genetic abnormalities and these conditions.
  • A significant percentage of fetuses with isolated or complex CHDs demonstrated abnormal CNVs, indicating that traditional chromosomal analyses alone may not capture all genetic factors involved in these defects.
  • The study suggests that using high-resolution SNP arrays enhances diagnostic rates and helps clarify the genetic underpinnings of CHDs through the detection of pathogenic deletions and duplications in specific genes.
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Introduction: Recent studies have found that lipid levels in patients with chronic hepatitis B (CHB) may change during antiviral therapy.

Objective: To assess the effects of first-line nucleot(s)ide analogues (NAs) on lipid profiles in patients with CHB using network meta-analysis.

Methods: Seven electronic databases (PubMed, Embase, Cochrane Library, and four Chinese databases) were searched for cohort studies on the effect of NA on lipids in patients with CHB up to August 1, 2023.

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Objective: To explore the differential expression of genes between wild-type chronic compressive injury (CCI) mice (WT-CCI) and interferon regulatory factors 4 (IRF4) knockout CCI mice (KO-CCI) by RNA-seq analysis of the mouse spinal cord.

Methods: RNA-seq analysis of the spinal cord tissue of the chronic sciatic nerve ligation mice and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were used.

Results: A total of 104 genes were up-regulated and 116 genes were down-regulated in spinal cord of the mice in IRF4 knockout (KO-CCI) group compared with that in the wild-type CCI (WT-CCI) group.

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Ginsenoside Rg1 (GRg1), a key bioactive component of medicinal herbs, has shown beneficial effects on non-alcoholic fatty liver disease (NAFLD) and numerous other conditions. Nevertheless, the specific targets that are actively involved and the potential mechanisms underlying NAFLD treatment remain unclear. This study aimed to elucidate the therapeutic effects and mechanism of GRg1 in alleviating NAFLD using a combined approach of network pharmacology and molecular biology validation.

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In the era of single-cell biology, spatial proteomics has emerged as an important frontier. However, it still faces several challenges in technology. Formalin-fixed paraffin-embedded (FFPE) tissues are an important material in spatial proteomics, in which fixed tissues are excised using laser capture microdissection (LCM), followed by protein identification with mass spectrometry.

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Background: Hepatocellular carcinoma (HCC) comprises several distinct molecular subtypes with varying prognostic implications. However, a comprehensive analysis of a prognostic signature for HCC based on molecular subtypes related to disulfidptosis and glycolysis, as well as associated metabolomics and the immune microenvironment, is yet to be fully explored.

Methods: Based on the differences in the expression of disulfide-related glycolytic genes (DRGGs), patients with HCC were divided into different subtypes by consensus clustering.

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Droplet digital polymerase chain reaction (ddPCR) is a new quantitative PCR method based on water-oil emulsion droplet technology. ddPCR enables highly sensitive and accurate quantification of nucleic acid molecules, especially when their copy numbers are low. In ddPCR, a sample is fractionated into ~20,000 droplets, and every nanoliter-sized droplet undergoes PCR amplification of the target molecule.

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Peripheral neurotoxicity injury caused by local anesthetics is a common complication of clinical anesthesia. The study of its mechanism is helpful to prevent and treat the neurotoxic injury of local anesthetics. Previous studies on peripheral neurotoxicity injury caused by local anesthetics have mainly focused on in vitro cell experiments.

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