Background: The effects of restrictive versus liberal transfusion strategies in critically ill patients with traumatic brain injury (TBI) and anemia, particularly in adult patients with moderate to severe TBI, remain inconclusive. Therefore, this systematic review and meta-analysis aim to evaluate the comparative impact of restrictive and liberal red blood cell transfusion strategies among critically ill adult patients with moderate to severe TBI.
Methods: We conducted a search of PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials from their inception through October 20, 2024, to identify randomized controlled trials that compared restrictive (transfusions at a hemoglobin level of ≤ 7 g/dL) and liberal (transfusions at a hemoglobin level of ≤ 9-10 g/dL) transfusion strategies in adult patients with TBI.
Background: Aerobic glycolysis is a tumor cell phenotype and a hallmark in cancer research. The alternative splicing of the pyruvate kinase M (PKM) gene regulates the expressions of PKM1/2 isoforms and the aerobic glycolysis of tumors. Polypyrimidine tract binding protein (PTBP1) is critical in this process; however, its impact and underlying mechanisms in colorectal cancer (CRC) remain unclear.
View Article and Find Full Text PDFIn this work, lactoferrin (LF)-chitosan (CS) composite hydrogels with good loading capacity of thermosensitive bioactive substances were successfully obtained by microbial transglutaminase (MTG)-induced cross-linking. We evaluated the rheological, textural, and microstructural characteristics of the composite hydrogels under different conditions. The results demonstrated that the concentrations of LF and CS as well as the amount of MTG could regulate the textural properties, rheological properties, and water holding capability.
View Article and Find Full Text PDFLactoferrin (LF) with various biological functions demonstrates great application potential. However, its application was restricted by its poor gelation and instability. The aim of this work was to explore the effect of microbial transglutaminase (MTGase) and Tremella fuciformis polysaccharide (TP) on the functional properties of LF.
View Article and Find Full Text PDFHerein, we reported a new contaminant purification paradigm, which enabled highly efficient reductive denitration and dechlorination using a green, stable reducing agent thiourea dioxide (TDO) coupled with biochar (BC) over a wide pH range under anoxic conditions. Specifically, BC acted as both activators and electron shuttles for TDO decomposition to achieve complete anoxic degradation of p-nitrophenol (PNP), p-nitroaniline, 4-chlorophenol and 2,4-dichlorophenol within 2 h. During this process, multiple strongly reducing species (i.
View Article and Find Full Text PDFMung bean protein isolate (MBPI) has attracted much attention as an emerging plant protein. However, its application was limited by the poor gelling characteristics. Thus, the effect of sanxan (SAN) on the gelling behavior of MBPI under microbial transglutaminase (MTG)-induced condition were explored in this study.
View Article and Find Full Text PDFAerobic composting stands as a widely-adopted method for treating organic solid waste (OSW), simultaneously producing organic fertilizers and soil amendments. This biologically-driven biochemical reaction process, however, presents challenges due to its complex non-linear metabolism and the heterogeneous nature of the solid medium. These characteristics inherently limit the simulation accuracy and efficiency optimization in aerobic composting.
View Article and Find Full Text PDFMature compost is safe and stable, yet quality assessments are challenging owing to current maturity indicators' limitations. This study employed density fractionation to separate organic carbon into light and heavy fractions, offering a new perspective for assessing maturity. Results showed that light fraction organic carbon progressively transitioned into heavy fraction during composting, reducing the proportion of total organic carbon from 82.
View Article and Find Full Text PDFThe low gelation capacity of pea protein isolate (PPI) limits their use in food industry. Therefore, microbial transglutaminase (MTG) and apple pectin (AP) were combined to modify PPI to enhance its gelling characteristics, and the mechanism of MTG-induced PPI-AP composite gel generation was investigated. PPI (10 wt%) could not form a gel at 40 °C, while MTG-treated PPI (10 wt%) formed a self-supporting gel at 40 °C.
View Article and Find Full Text PDFAlthough synaptotagmin 1 (SYT1) has been identified participating in a variety of cancers, its role in colorectal cancer (CRC) remains an enigma. This study aimed to demonstrate the effect of SYT1 on CRC metastasis and the underlying mechanism. We first found that SYT1 expressions in CRC tissues were lower than in normal colorectal tissues from the CRC database and collected CRC patients.
View Article and Find Full Text PDFBackground: Blood-based tests have public appeal in screening cancers due to their minimally invasive nature, ability to integrate with other routine blood tests, and high compliance. This study aimed to investigate whether certain epigenetic modulation of peripheral blood mononuclear cells (PBMCs) could be a biomarker of colorectal cancer (CRC).
Results: Western blotting of histones in the PBMCs from 40 colorectal cancer patients and 40 healthy controls was performed to identify the crotonylation sites of proteins.
High-temperature laser bed powder fusion (HT-LPBF) technology is an ideal method for processing poly-ether-ether-ketone (PEEK) implants with personalized bionic structures, but the biological inertia of PEEK limits its medical applications. In this study, we evaluated the mechanical and biological properties of a novel akermanite (AKM)/PEEK composite for HT-LPBF. The results showed that tiny AKM particles are evenly attached to the surface of the PEEK particle.
View Article and Find Full Text PDFLivestock and poultry manure are repositories of antibiotic resistance genes (ARGs). Accumulating evidence suggests that composting is an important way to effectively attenuate ARGs, but how to reinforce the reduction in ARGs during composting needs to be further investigated. This study explored the influence of an external static magnetic field on ARG mitigation enhancement during swine manure composting.
View Article and Find Full Text PDFAnaerobic digestion (AD) is a promising technology for recovering value-added resources from organic waste, thus achieving sustainable waste management. The performance of AD is dictated by a variety of factors including system design and operating conditions. This necessitates developing suitable modelling and optimization tools to quantify its off-design performance, where the application of machine learning (ML) and soft computing approaches have received increasing attention.
View Article and Find Full Text PDFUntil now, Streptoverticillium mobaraense transglutaminase (TG) is the only commercialized TG, but limited information is known about its selection tendency on crosslinking sites at the protein level, restricting its application in the food industry. Here, four recombinant Bacillus TGs were stable in a broad range of pH (5.0−9.
View Article and Find Full Text PDFScleroglucan is obtained from and is widely used in many fields. In this study, transcriptomics combined with metabolomics were used to study the global metabolites and gene changes. The results of the joint analysis showed that the DEGs (differentially expressed genes) and DEMs (differentially expressed metabolites) of SEPS_48 (fermented with sucrose as a carbon source for 48 h) and GEPS_48 (fermented with glucose as a carbon source for 48 h) comparison groups were mainly related to cell metabolism, focusing on carbohydrate metabolism, amino acid metabolism, and amino sugar and nucleoside sugar metabolism.
View Article and Find Full Text PDFCOVID-19 has had a lasting impact on the public's mental health. Understanding the mechanism of the formation of the public's aversion to COVID-19-infected people can not only help eliminate the irrational stigma, rejection, and aversion of the public but also promote the creation of a harmonious and healthy social atmosphere. Based on stimulus-organism-response theory, this study explored the relationships between environmental stimuli, public negative physiology, and aversion responses.
View Article and Find Full Text PDFBackground: Bladder cancer (BLCA) is one of the most common genitourinary malignancies in the world, but its pathogenic genes have not been fully identified and the treatment outcomes are still unsatisfactory. Although the members of 2', 5'-oligoadenylate synthetase (OAS) gene family are known involved in some tumorous biological processes, the roles of the OAS gene family in BLCA are still undetermined.
Methods: By combining vast bioinformatic datasets analyses of BLCA and the experimental verification on clinical BLCA specimen, we identified the expressions and biological functions of OAS gene family members in BLCA with comparison to normal bladder tissues.
Front Psychol
August 2022
China leads the world in the development and rollout of 5G network, yet less research has been done on the drivers of Chinese people's adoption of 5G network, especially the specific role of national sentiments, such as the influence of patriotism on their attitude toward 5G network. The study obtained 804 effective online questionnaires from the respondents of various ages, genders, areas, and educational levels. The results based on the structural equation modeling (SEM) analysis showed that patriotism was an antecedent to Chinese users' cognition of the conditions provided by the government and telecom operators and the extent that users were influenced by media and surrounding people, which in turn increased users' expectations of the performance of 5G network and their confidence in adapting to 5G network, and resulted in an increased willingness to use 5G network.
View Article and Find Full Text PDFA prediction model of the welding process of Ti-6Al-4V titanium alloy was established by using the finite element method, which was used to evaluate the phase composition, residual stress and deformation of the welded joints of Ti-6Al-4V sheets with different processes (including tungsten inert gas welding, TIG, and laser beam welding, LBW). The Ti-6Al-4V structures of TIG welding and LBW are widely used in marine engineering. In order to quantitatively study the effects of different welding processes (including TIG welding and LBW) on the microstructure evolution, macro residual stress and deformation of Ti6Al4V titanium alloy sheets during welding, a unified prediction model considering solid-state phase transformation was established based on the ABAQUS subroutine.
View Article and Find Full Text PDFBiochem Biophys Res Commun
November 2021
Lysine crotonylation (Kcr) is a newly identified protein translational modification and is involved in major biological processes including glycolysis, but its role in colorectal cancer (CRC) is unknown. Here, we found that the Kcr of α enolase (ENO1) was significantly elevated in human CRC tissues compared with the paratumoral tissues. CREB-binding protein (CBP) functioned as a crotonyltranferase of ENO1, and SIRT2 was involved in the decrotonylation of ENO1.
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