Publications by authors named "Jiayi Ai"

Article Synopsis
  • - Gallium (Ga(III)) is emerging as a potential antibacterial agent with unique mechanisms, differing from traditional antibiotics by replacing iron in bacterial processes.
  • - In a study, researchers used quantitative proteomics to analyze how Ga(NO) affects Pseudomonas aeruginosa, finding that Ga(III) inhibits bacterial growth by altering key metabolic pathways and reducing the expression of virulence-related proteins.
  • - The findings highlight the importance of understanding bacterial metabolic responses to Ga(III), suggesting it could enhance treatment strategies against antibiotic-resistant infections.
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The high mechanical strength and self-healing properties of hydrogels are the focus of tissue engineering and biomedical research. Furthermore, the incompatibility between hydrogel toughness and self-healing has not been resolved. It is noteworthy that the double network (DN) hydrogels show great promise as a viable method for producing self-healing hydrogels with the above properties.

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Background: The Chinese herbal compound Heshouwuyin has been shown to downregulate the apoptotic rate of testicular tissue cells in Wistar naturally aging rats, and this effect might be related to the mitochondrial pathway [15]. Apoptotic protease activating factor-1 (Apaf-1) is a major component of the apoptotic complex, which is a key element of the mitochondrial endogenous apoptotic pathway [13]. To further clarify the mechanism of Heshouwuyin in the mitochondrial apoptotic pathway, this study used Apaf-1 as a target to explore the mechanism by which Heshouwuyin inhibits the Apaf-1 pathway of spermatogenic cell apoptosis.

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