Psychological stress disturbs bone metabolism via miR-335-3p/Fos signaling in osteoclast.

It has been well validated that chronic psychological stress leads to bone loss, but the underlying mechanism remains unclarified. In this study, we established and analyzed the chronic unpredictable mild stress (CUMS) mice to investigate the miRNA-related pathogenic mechanism involved in psychological stress-induced osteoporosis. Our result found that these CUMS mice exhibited osteoporosis phenotype that is mainly attributed to the abnormal activities of osteoclasts.

Identification and Molecular Marker Detection of Leaf Rust Resistance Genes in Wheat Lines from China: Development of an Efficient Software for Gene Postulation.

Wheat leaf rust, caused by Erikss. (), is one of the most devastating diseases in common wheat ( L.) globally.

Concomitant chronic lateral ankle instability affects postoperative functional outcomes in patients with osteochondral lesions of the talus, but does not affect cartilage repair after restoration of ankle stability.

Purpose: To investigate the effect of concomitant chronic lateral ankle instability (CLAI) on postoperative clinical outcomes in patients with osteochondral lesions of the talus (OLTs).

Methods: Patients who underwent surgery for OLTs between January 2018 and May 2022 were retrospectively evaluated. OLT procedures involved debridement, microfracture, or bone grafting, while concomitant CLAI underwent lateral ligament repair or reconstruction.

Artificial Intelligence in Medical Metaverse: Applications, Challenges, and Future Prospects.

The medical metaverse is a combination of medicine, computer science, information technology and other cutting-edge technologies. It redefines the method of information interaction about doctor-patient communication, medical education and research through the integration of medical data, knowledge and services in a virtual environment. Artificial intelligence (AI) is a discipline that uses computer technology to study and develop human intelligence.

Application and Prospects of Deep Learning Technology in Fracture Diagnosis.

Artificial intelligence (AI) is an interdisciplinary field that combines computer technology, mathematics, and several other fields. Recently, with the rapid development of machine learning (ML) and deep learning (DL), significant progress has been made in the field of AI. As one of the fastest-growing branches, DL can effectively extract features from big data and optimize the performance of various tasks.

Performance Assessment of GPT 4.0 on the Japanese Medical Licensing Examination.

Objective: To evaluate the accuracy and parsing ability of GPT 4.0 for Japanese medical practitioner qualification examinations in a multidimensional way to investigate its response accuracy and comprehensiveness to medical knowledge.

Methods: We evaluated the performance of the GPT 4.

Energy-Efficient Adaptive Bidirectional Transmission Strategy in Simultaneous Wireless Information and Power Transfer (SWIPT)-Enabled Cognitive Relay Network.

Introducing collaborative relay and simultaneous wireless information and power transfer (SWIPT) techniques into a cognitive wireless network, named the SWIPT-enabled cognitive relay network (CRN), is considered a promising approach to deal with insufficiency and the low utilization of spectrum resources, as well as the node's energy-constrained issues in wireless networks. In this paper, to improve the network spectrum efficiency (SE) and energy efficiency (EE) of the SWIPT-enabled CRN, we design an energy-efficient adaptive bidirectional transmission strategy. To be specific, we first select an energy-constrained best relay node with the consideration of signal-to-noise ratio and global channel gain to achieve a better bidirectional relay transmission (BRT).

Comparative analysis of three jaw motion tracking systems: A study on precision and trueness.

Purpose: The purpose of this study was to assess the precision and trueness of three jaw motion tracking systems, the KaVo ARCUSdigma system, SDiMatriX system, and Modjaw system, in recording mandibular movements based on optical and ultrasonic principles.

Materials And Methods: Twenty-five healthy subjects were selected for the present study to measure protrosive movement and left and right lateral movements using the three jaw motion tracking systems. Each subject's mandibular movement was recorded twice with a 1-week interval.

Comparison between a Novel Knee Arthrometer and Simultaneous Stress Radiography for the Diagnosis of Complete and Partial Acute Anterior Cruciate Ligament Tears.

Objectives: The type of ligamentous tear and the degree of knee laxity have important guiding significance for the diagnosis and management of anterior cruciate ligament (ACL) tears. Instrumental measurement is necessary for ACL tears since physical examination and magnetic resonance imaging (MRI) cannot provide an objective and quantitative assessment of knee laxity. This study aimed to compare the application of a novel knee arthrometer and simultaneous stress radiography in differentiating between complete and partial acute ACL tears, and further assess the correlation between the two measurements.

Effects of bacteriocin-producing Lactiplantibacillus plantarum on bacterial community and fermentation profile of whole-plant corn silage and its in vitro ruminal fermentation, microbiota, and CH emissions.

Background: Silage is widely used to formulate dairy cattle rations, and the utilization of antibiotics and methane emissions are 2 major problems for a sustainable and environmentally beneficial ruminant production systems. Bacteriocin has received considerable attention because of its potential as an alternative to antibiotics in animal husbandry. However, the impact of bacteriocin-producing lactic acid bacteria on the microbiological conversion process of whole-plant corn silage and rumen fermentation remains limited.

Gene editing therapy for cardiovascular diseases.

The development of gene editing tools has been a significant area of research in the life sciences for nearly 30 years. These tools have been widely utilized in disease detection and mechanism research. In the new century, they have shown potential in addressing various scientific challenges and saving lives through gene editing therapies, particularly in combating cardiovascular disease (CVD).

Does a Video-Based and 3D Animation Hybrid Learning System Improve Teaching Outcomes in Orthopedic Surgery? A Randomized Controlled Trial.

Objective: This study aims to evaluate the instructional efficacy of a 3D Surgical Training System (3DSTS), which combines real surgical footage with high-definition 3D animations, against conventional surgical videos and textbooks in the context of orthopedic proximal humerus fracture surgeries.

Design: Before the experiment, 89 participants completed a pre-educational knowledge assessment. They were then randomized into 3 groups: the 3DSTS group (n = 30), the surgical video (SV) group (n = 29), and the textbook group (n = 30).

Early Postoperative Rapid Rehabilitation Yields More Favorable Short-term Outcomes in Patients Undergoing Patellar Realignment Surgery for Recurrent Patellar Dislocation: A Prospective Randomized Controlled Study.

Background: Use of a rapid rehabilitation protocol for postoperative recovery after recurrent patellar dislocation (RPD) has gradually gained attention; nonetheless, evidence of its safety and effectiveness is lacking.

Purpose: To compare the short-term postoperative outcomes of early rapid rehabilitation with those of conservative rehabilitation in patients with RPD.

Study Design: Randomized controlled trial; Level of evidence, 2.

circ_WASF2 regulates ferroptosis by miR-634/ GPX4 signaling in pancreatic cancer.

Purpose: Pancreatic cancer (PC) is one of the most lethal malignant gastrointestinal tumors (GI) characterized by a poor prognosis. Ferroptosis is an emerging programmed cell death that plays an essential role in the progression of various cancers. Ferroptosis is driven by iron-dependent phospholipid peroxidation and is regulated by mitochondrial activity, lipid peroxidation, and reactive oxygen species (ROS).

Influence of Subchondral Cysts on the Outcomes of Surgical Treatment for Osteochondral Lesions of the Talus: A Systematic Review and Meta-analysis.

Background: Limited literature is available regarding the effect of subchondral cysts on the surgical outcomes for treatment of osteochondral lesion of the talus (OLT).

Purpose: To conduct a systematic review and meta-analysis of studies comparing surgical outcomes between OLTs with and without cysts.

Study Design: Systematic review; Level of evidence, 4.

Dynamic membrane filtration accelerates electroactive biofilms in bioelectrochemical systems.

Bioelectrochemical systems (BES) have emerged as a dual-function technology for treating wastewater and recovering energy. A vital element of BES is the rapid formation and maintenance of electroactive biofilms (EABs). Previous attempts to accelerate EAB formation and improve electroactivities focused on enhancing the bacterial adhesion process while neglecting the rate-limiting step of the bacterial transport process.

Primary hepatic mucosa-associated lymphoid tissue lymphoma complicated with atrial fibrillation: A case report and literature review.

Rationale: Primary hepatic mucosa-associated lymphoid tissue (MALT) lymphoma is a rare malignant primary hepatic lymphoma. The sensible choice of treatment for patients with primary lymphoma combined with atrial fibrillation (AF) is controversial and challenging.

Patient Concerns: The patient presented with both primary hepatic MALT lymphoma and AF, which was difficult to manage.