Molecular acceptor engineering to precisely design a NIR type I photosensitizer for efficient PDT-based synergistic therapy.

Molecular design plays a crucial role in regulating the photophysical properties and photodynamic therapy (PDT) performance of photosensitizers (PSs); however, realizing PDT-based synergistic therapy based on sole PSs is still rarely reported. Herein, three near-infrared red type I PSs (named TP1, TP2, and TP3) were synthesized by adjusting their electron acceptors. The results demonstrated that these PSs exhibited aggregation-enhanced reactive oxygen species (ROS) generation efficiency and cyano groups on PSs can reduce ROS generation in solution while achieving efficient PDT-based synergistic therapy in cells glutathione depletion.

Diversity and Evolution of Genes in Species.

genes are crucial components of the effector-triggered immunity (ETI) system, responsible for recognizing pathogens and initiating immune responses. Although genes in many plant species have been extensively studied, the diversity of genes in remains largely unknown. Our analysis revealed significant variations in the copy numbers of genes among these species.

One-step synthesis of a dual-functional AIE-active probe for ClO detection and photodynamic therapy.

An amphiphilic fluorescent probe (BHSMP) with aggregation-induced emission (AIE) features was synthesized a one-step route. The probe showed high water dispersibility, low toxicity and the ability of selective and sensitive (limit of detection of 0.11 µM) detection of ClO with fast-response (≤30 s) in aqueous solution and living organisms.