Ischemia-reperfusion injury induces ZBP1-dependent PANoptosis in endothelial cells.

Endothelial cells play a critical role in the pathophysiology of ischemia-reperfusion injury (IRI). Although previous studies have shown that IRI can activate PANoptosis, the underlying mechanisms remain unclear. Our research investigates how IRI induces PANoptosis in endothelial cells, aiming to identify protective strategies to safeguard these cells from PANoptosis triggered by IRI.

Sturnus vulgaris escape algorithm and its application to mechanical design.

Practical engineering optimization problems are characterized by high dimensionality, non-convexity, and non-linearity, and the use of optimizers to provide better quality solutions to the target problem in an acceptable time is a hot research topic in the field of optimal design. In this paper, inspired by the Sturnus vulgaris escape behavior, a Sturnus Vulgaris Escape Algorithm (SVEA) is proposed to provide a high-performance optimizer for complex optimization problems. The algorithm is composed of exploration and exploitation strategies, controlled by fixed parameters.

Fast-track surgery with three-port versus conventional perioperative management of bladder cancer associated laparoscopic radical cystectomy and Ileal conduit diversion: Chinese experience.

Objective: This study seeks to explore the impact of fast track surgery (FTS) with three-port in patients treated with laparoscopic radical cystectomy and ileal conduit on postoperative recovery, hospital stay and the complications.

Methods: This retrospective study analyzed 230 patients with invasive bladder cancer who underwent laparoscopic radical cystectomy at the Second Hospital of Anhui Medical University between December 2011 to January 2023. 50 patients received conventional surgery (CS) and 180 patients received FTS with three-port.

Characteristics of tunneling nanotube-like structures formed by human dermal microvascular pericytes in vitro.

Tunneling nanotubes (TNTs) represent an innovative way for cells to communicate with one another, as they act as long conduits between cells. However, their roles in human dermal microvascular pericytes (HDMPCs) interaction remain elusive in vitro. In this work, we identified and characterized the TNT-like structures that connected two or more pericytes in two-dimensional cultures and formed a functional network in the human dermis.

Sulfite-Assisted Acetate Conversion from CO Electroreduction.

The efficient acetate conversion from CO electroreduction is challenging due to the poor selectivity at high reaction rate, which requires the competition with H and other C (i. e., ethylene, ethanol, n-propanol) reduction products.

(111) Facet-oriented CuMg Intermetallic Compound with Cu-Mg Sites for CO Electroreduction to Ethanol with Industrial Current Density.

The efficient ethanol electrosynthesis from CO is challenging with low selectivity at high CO electrolysis rates, due to the competition with H and other reduction products. Copper-based bimetallic electrocatalysts are potential candidates for the CO-to-ethanol conversion, but the secondary metal has mainly been focused on active components (such as Ag, Sn) for CO electroreduction, which also promote selectivity of ethylene or other reduction products rather than ethanol. Limited attention has been given to alkali-earth metals due to their inherently active chemical property.

High-power quantum-limited 35 MHz photodiode and classical laser noise suppression.

To benefit high-power interferometry and the creation of low-noise light sources, we develop a simple lead-compensated photodetector enabling quantum-limited readout from 0.3 to 10 mW and 10 kΩ gain from 85 Hz to 35 MHz, with a noise equivalent power of 9 pW/Hz. Feeding the detector output back to an intensity modulator, we suppress the classical amplitude noise of a commercial 1550 nm fiber laser to the shot noise limit over a bandwidth of 700 Hz-200 kHz, observing no degradation to its (nominally ∼100 Hz) linewidth.

[Corrigendum] Curcumin reverses benzidine-induced epithelial-mesenchymal transition via suppression of ERK5/AP-1 in SV-40 immortalized human urothelial cells.

Following the publication of the above article, an interested reader drew to the authors' attention that, for the Transwell invasion assays shown in Fig. 5D on p. 1326, the images selected for the '0 μM benzidine / 0 μM curcumin' and '0 μM benzidine / 1 μM curcumin' experiments were overlapping, such that these data appeared to have been derived from the same original source.

Long non-coding RNA SNHG1 promotes bladder cancer progression by upregulating EZH2 and repressing KLF2 transcription.

Objective: Long Non-Coding RNAs (LncRNAs) act as an indispensable role in cancer development. The study aimed to investigate the role and mechanism of lncRNA Small Nucleolar RNA Host Gene 1 (SNHG1) in Bladder Cancer (BC) progression.

Method: The expression, prognostic value, diagnostic value, and correlation of SNHG1, Enhancer of Zeste 2 polycomb repressive complex 2 subunit (EZH2), and Kruppel Like Factor 2 (KLF2) were analyzed through bioinformatics analysis.

Preparation and evaluation of a chitosan modified biochar as an efficient adsorbent for pipette tip-solid phase extraction of triazine herbicides from rice.

The low allowable limit of triazine herbicides (THs) in rice makes it imperative to develop novel sample pretreatment methods for extraction and preconcentration of THs. Herein, a phosphoric acid activated biochar (PBC) was prepared and modified by chitosan (CS). For THs with different polarities, CS-PBC with multiple interaction sites exhibited satisfactory chemisorption.

Enhancement of nitrogen removal by a modular design of vertical flow constructed wetlands with a plant carbon source: Optimization of carbon dosage for nitrogen removal, practicability evaluation and strategy exploration for water quality control.

The requirement of artificial aeration for increasing nitrogen removal in vertical flow constructed wetlands (VFCWs) brings extra energy consumption and complex maintenance. The feasibility of a modular design to replace artificial aeration for partially saturated VFCWs with palm bark as a carbon source (PSVFCW-pb) to achieve water quality control, especially nitrogen removal was evaluated. The PSVFCW-pb with a spatially separate structure and perforated peripheries for better oxygen diffusion had a promising total nitrogen removal (e.

Cholecalciferol pretreatment ameliorates ischemia/reperfusion-induced acute kidney injury through inhibiting ROS production, NF-κB pathway and pyroptosis.

Acute kidney injury (AKI) is a common complication in patients with potentially life-threatening diseases, and it is also usually associated with unacceptable morbidity and mortality rates. Therefore, new and efficient therapies are urgently required to relieve AKI. It is well known that, reactive oxygen species (ROS), the NF-κB signaling pathways and pyroptosis are involved in AKI induced by ischemia/reperfusion (I/R).

Modified vein clamping technique for renal cell carcinoma complicated with level I-II IVC thrombi: a study at a single centre.

Objectives: To share our initial experience with the modified vein clamping technique for the treatment of renal cell carcinoma complicated with level I-II IVC thrombi.

Methods: From March 2018 to April 2021, 11 patients with renal cell carcinoma (RCC) involving an IVC tumour thrombus were admitted to our hospital. They all underwent laparoscopic radical nephrectomy and IVC thrombectomy (LRN-IVCTE) using a modified vein clamping technique.

Retroperitoneal transperitoneal laparoscopic lithotripsy of 20-40 mm renal stones within horseshoe kidneys.

Background: Horseshoe kidney (HK) with renal stones is challenging for urologists. Although both retroperitoneal and transperitoneal laparoscopic approaches have been reported in some case reports, the therapeutic outcome of retroperitoneal compared with transperitoneal laparoscopic lithotripsy is unknown.

Aim: To assess the efficacy of laparoscopic lithotripsy for renal stones in patients with HK.

Monitored wet-etch removal of individual dielectric layers from high-finesse Bragg mirrors.

It is prohibitively expensive to deposit customized dielectric coatings on individual optics. One solution is to batch-coat many optics with extra dielectric layers, then remove layers from individual optics as needed. Here we present a low-cost, single-step, monitored wet etch technique for reliably removing individual SiO and TaO dielectric layers, in this case from a high-reflectivity fiber mirror.

Highly tunable nonlinear response of Au@WS hybrids with plasmon resonance and anti-Stokes effect.

We synthesize Au@WS2 hybrid nanobelts and investigate their third-order nonlinear responses mediated by a strong anti-Stokes effect. By using the femtosecond Z-scan technique and tuning the excitation photon energy (Eexc), we find the sign reversals of both nonlinear absorption coefficient β and nonlinear refractive index γ to be around 1.60 eV, which is prominently higher than the bandgap (1.

Early Unclamping Laparoscopic Partial Nephrectomy for Complex Renal Tumor: Data from a Chinese Cohort.

Objective: To evaluate the efficacy and safety of early unclamping laparoscopic partial nephrectomy (LPN) for complex renal tumor relative to the standard artery clamping technique (SCT).

Methods: Sixty-one patients with complex renal tumor (RENAL score ≥7) underwent LPN at our institution from January 2013 to April 2017. LPN was performed via SCT in 32 patients and via the early unclamping technique (EUT) in 29 patients.

Curcumin inhibits bladder cancer stem cells by suppressing Sonic Hedgehog pathway.

Cancer stem cells (CSCs) is responsible for the recurrence of human cancers. Thus, targeting CSCs is considered to be a valid way for human cancer treatment. Curcumin is a major component of phytochemicals that exerts potent anticancer activities.

Curcumin reverses benzidine-induced epithelial-mesenchymal transition via suppression of ERK5/AP-1 in SV-40 immortalized human urothelial cells.

Overexposure to benzidine has been manifested as an important cause of bladder cancer. However, the molecular mechanism of benzidine-induced malignancy is still insufficiently interpreted. Epithelial-mesenchymal transition (EMT) is a crucial pathophysiological process in embryonic development as well as initiation and development of epithelium-originated malignant tumors.