Hordeum I genome unlocks adaptive evolution and genetic potential for crop improvement.

Crop wild relatives (CWRs) are invaluable for crop improvement. Among these, Hordeum I-genome species exhibit exceptional tolerance to alkali and salt stresses. Here we present a chromosome-scale genome assembly of Hordeum brevisubulatum (II, 2n = 2x =14) and genome resequencing of 38 diploid germplasms spanning 7 I-genome species.

Down-regulation of TET2 inhibits testosterone synthesis in offspring mice exposed to DBP during pregnancy through LH/cAMP/PKA/StAR signaling mediated by LHR.

Exposure to di-n-butyl phthalate (DBP) during embryo development or lactation has been linked to reproductive toxicity. The ten-eleven translocation (TET) protein family plays a role in various pathological processes; however, its involvement in reproductive dysfunction in offspring mice exposed to DBP during gestation remains sparsely reported. In this study, SPF C57BL/6 pregnant mice were intragastrically administered DBP at doses of 0.

Research Progress of Bioactive Peptides in Improving Type II Diabetes.

Type II diabetes mellitus (T2DM) is a prevalent, long-standing metabolic condition marked by the body's reduced response to insulin and inadequate insulin production, impacting a significant portion of the global population. Research has demonstrated that bioactive peptides play a crucial role in reducing blood sugar levels, enhancing insulin sensitivity, balancing lipid metabolism, and combating inflammation. These peptides also contribute to the enhancement of pancreatic islet function, lowering systemic inflammation by influencing various molecular signaling pathways.

Nrf2 deficiency aggravates hepatic cadmium accumulation, inflammatory response and subsequent injury induced by chronic cadmium exposure in mice.

Prolonged cadmium (Cd) exposure leads to Cd accumulation and oxidative damage in the liver. Nuclear factor erythroid-derived 2-like 2 (NRF2) plays a vital role in preventing acute hepatic toxicity of Cd. However, the participation of NRF2 in chronic liver injury, especially in the context of chronic Cd exposure, has rarely been investigated.

Three-dimensional measurement of the depth of invasion in oral squamous cell carcinoma samples using Lugol's iodine-enhanced micro-computed tomography: an original study.

Objectives: Depth of invasion (DOI) in oral squamous cell carcinoma (OSCC) guides treatment and prognosis but lacks three-dimensional (3D) insight. Thus, this study aimed to investigate the feasibility and accuracy of Lugol's iodine-enhanced micro-computed tomography (CT) for the 3D measurement of DOI in OSCC samples.

Methodology: In total, 50 in vitro OSCC samples from Nanjing Stomatological Hospital (July 2022 to January 2024) were subjected to micro-CT imaging with a slice thickness of 50 μm following 3% Lugol iodine staining for 12 h, followed by pathological examination and staining.

Flexible Mushroom-Like Cross-Scale Surface with Extreme Pressure Resistance for Telecommunication Lines Anti-Icing/Deicing.

Ice accretion caused by freezing rain or snowstorms is a common phenomenon in cold climates that seriously threatens the safety and reliability of telecommunication lines and other overhead networks. Various anti-icing strategies have been demonstrated through surface engineering to delay ice formation. However, existing anti-icing surfaces still encounter several challenges; for example, surfaces are prone to ice-pinning formation due to the impact of supercooled droplets, which leads to a loss of anti-icing effectiveness.

A Fluorine-Functionalized Tb(III)-Organic Framework for Ba Detection.

The development of lanthanide-organic frameworks (Ln-MOFs) using for luminescence sensing and selective gas adsorption applications is of great significance from an energy and environmental perspective. This study reports the solvothermal synthesis of a fluorine-functionalized 3D microporous Tb-MOF with a face-centered cubic () topology constructed from hexanuclear clusters (TbO) bridged by fdpdc ligands, formulated as {[Tb(fdpdc)(-OH)(HO)]·4DMF} (), (fdpdc = 3-fluorobiphenyl-4,4'-dicarboxylate). Complex displays a 3D framework with the channel of 7.

A Positive Relationship Between Caffeine Intake and Endometriosis: A Cross-Sectional Study of the National Health and Nutrition Examination Survey 1999-2006.

Background: Caffeine has been suggested to have a relationship with endometriosis as a widely consumed psychoactive substance, although findings are inconsistent.

Objective: This study explored the potential associations and threshold effects between caffeine intake and endometriosis using cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2006.

Methods: The study included 248 women with endometriosis and 2944 without, aged 20-50 years.

Nomogram Based on Immune-Inflammatory Score and Classical Clinicopathological Parameters for Predicting the Recurrence of Endometrial Carcinoma: A Large, Multi-Center Retrospective Study.

Background: Surgery is the best approach to treat endometrial cancer (EC); however, there is currently a deficiency in effective scoring systems for predicting EC recurrence post-surgical resection. This study aims to develop a clinicopathological-inflammatory parameters-based nomogram to accurately predict the postoperative recurrence-free survival (RFS) rate of EC patients.

Methods: A training set containing 1068 patients and an independent validation set consisting of 537 patients were employed in this retrospective study.

Identification and characterization of soybean phytochrome-interacting factors and their potential roles in abiotic stress.

Phytochrome-interacting factors (PIFs) belong to a subfamily of the bHLH transcription factor family and play a pivotal role in plant light signal transduction, hormone signal pathways, and the modulation of plant responses to various abiotic stresses. The soybean (Glycine max) is a significant food crop, providing essential oil and nutrients. Additionally, it is a vital industrial raw material and a lucrative cash crop.

Astaxanthin Prevents Oxidative Damage and Cell Apoptosis Under Oxidative Stress Involving the Restoration of Mitochondrial Function.

Oxidative stress (OS) is one of the factors that result in cell damage and the development of neurological diseases such as Alzheimer's disease (AD). Astaxanthin (ASTA), a natural compound known for its potent antioxidant properties, shows the biological activities in anti-apoptosis and antitumor. However, its specific mechanism on mitochondrial function remains unclear.

Experimental and numerical research on jet dynamics of cavitation bubble near dual particles.

The current paper delves into the jet dynamics arising from a cavitation bubble in proximity to a dual-particle system, employing both experimental methodology and numerical simulation. The morphological development of a laser-induced bubble as well as the production of jets are captured by utilizing high-speed photography. The principles of bubble morphology evolution and jet formation are revealed by a OpenFOAM solver, which takes into account the effects of two-phase fluid compressibility, phase changes, heat transfer, and surface tension.

Controllable Structure Design of an Organic Gel-Infused Porous Surface for Efficient Anti- and De-icing.

Icing causes many problems in daily life and with equipment stability, and many efforts have been made to remove surface icing. Herein, a novel organic gel-infused porous material is developed to achieve excellent de-icing performance. Porous polydimethylsiloxane (P-PDMS) composites with different pore sizes were prepared by a template method.

Sabatier Principle Driving Interface Defect Engineering on 3D Graphene-Like Encapsulated Cobalt Structure for Hydrogenation Reaction.

Establishing structural defects is a perspective way to increase the catalytic hydrogenation reaction. Toward Sabatier optimization for hydrogenation reaction with defect density offers guidance for designing optimal catalysts with the highest performance. A controllable synthesis strategy is reported for Co@NC-x catalyst induced by defect density.

Mediation analysis of brain magnetic resonance imaging variables with all-cause and cardiovascular disease-specific mortalities in persons with type 2 diabetes.

Aim: Glucose variation (GV) has emerged as a predictor of morbidity and mortality in persons with diabetes. However, no study has examined whether brain magnetic resonance imaging (MRI) variables mediated the association between mortality and GV.

Materials And Methods: This study was a retrospective cohort comprising 3,961 individuals with type 2 diabetes (T2D), whose electronic medical records were retrieved from a medical center between January 2001 and October 2021.

Non-releasing poly (ionic liquid) based hydrogel accelerates diabetic wound healing.

Persistent bacterial colonization, abnormal inflammatory responses, and impaired angiogenesis pose significant challenges to effective wound repair, particularly in diabetic wounds. Employing exogenous bioactive substances in wound dressings is a recognized approach to dynamically respond to the wound microenvironment and accelerate the repair process. However, this strategy can lead to the development of drug resistance and induce further tissue damage.

Parabens, bisphenols, and triclosan in coral polyps, algae, and sediments from sanya, China: Occurrence, profiles, and environmental implications.

Parabens, bisphenols (BPs), and triclosan (TCS) are common environmental phenols widely applied in industrial products, pharmaceuticals, and personal care products. They are endocrine disruptors and pervade the natural environment, causing significant detrimental impacts on ecosystems, including marine habitats. Therefore, in this study, 40 samples comprising coral polyps, algae, and sediments were collected from Sanya, Hainan Province, China, in which the presence and compositional profiles of parabens, BPs, and TCS were examined to identify their fate in the oceans.

Precision synthesis of diblock copolymers free radical photopolymerization.

Diblock copolymers of phenyl methacrylate (PMA) and butyl methacrylate (BMA) were synthesized using dual-wavelength photopolymerization with a bifunctional photoinitiator 2-(4-(2-hydroxy-2-methylpropanoyl)phenoxy)ethyl()-3-(1-methyl-1-pyrrol-2-yl)acrylate (PAA-2959).

Micro/Nano Hierarchical Crater-Like Structure Surface With Mechanical Durability and Low-Adhesion for Anti-Icing/Deicing.

Superhydrophobic surfaces have attracted significant attention for their ability to prevent ice formation and facilitate deicing without requiring external energy. However, these surfaces are often vulnerable to damage from external forces, leading to functional failure due to poor mechanical stability, which limits their widespread use. Drawing inspiration from the hierarchical groove of rose petals and the micropapillae of lotus leaves, a simple laser-based method is proposed to create a superhydrophobic surface with a micro/nano hierarchical crater-like structure (HCLS).

MHC-I-presented non-canonical antigens expand the cancer immunotherapy targets in acute myeloid leukemia.

Identification of tumor neoantigens is indispensable for the development of cancer immunotherapies. However, we are still lacking knowledge about the potential neoantigens derived from sequences outside protein-coding regions. Here, we comprehensively characterized the immunopeptidome landscape by integrating multi-omics data in acute myeloid leukemia (AML).

A retrospective study of the efficacy of sulbactam in the treatment of patients with extensively drug-resistant Acinetobacter baumannii infections.

Purpose: Sulbactam (SBT) is one of the most significant treatments for patients with extensively drug-resistant Acinetobacter baumannii (XDR-AB). However, the efficacy and safety of SBT and its high dose regimen has not been well documented. This retrospective study aimed to assess the efficacy and safety of SBT-based treatment, particularly at high-dose (≥ 6 g/day), for XDR-AB infection.

Investigation of mechanisms of shock wave generation by collapse of cavitation bubbles near particles.

The mechanism of generation of shock waves by the collapse of a cavitation bubble near a single particle or dual particles is numerically investigated using OpenFOAM. For the single-particle case, shock waves during bubble inception and jet impacting on the particle surface are revealed in detail. The pressure induced on the particle by the inception shock wave of the bubble decreases with increasing bubble-particle distance, and the pressure is proportional to 1/r (r being the distance from the center of the shock wave).

Jet dynamics of a cavitation bubble near unequal-sized dual particles.

The jet dynamics of a cavitation bubble near unequal-sized dual particles is investigated employing OpenFOAM, and the effects of the jets on the particles are quantitatively analyzed in terms of their pressure impacts. Different from single-particle cases, the necks that evolve between dual particles are closely linked to the formation mechanism of the jets. Based on the simulation results, the jet dynamics can be divided into five scenarios: (1) the contraction of the annular depression produced by the collision of the two necks causes the bubble to split into two daughter bubbles and generates a single jet inside each daughter bubble; (2) the annular depression impacts the particle, leading to the bubble to fracture and producing a single jet inside a daughter bubble; (3) the bubble is split by a single neck constriction and produces a single jet; (4) the bubble is split by a single neck constriction and generates two jets; and (5) the bubble is split by the contraction of two necks and produces four jets together with three daughter bubbles.

Gamma-aminobutyric acid (GABA) improves salinity stress tolerance in soybean seedlings by modulating their mineral nutrition, osmolyte contents, and ascorbate-glutathione cycle.

Background: In plants, GABA plays a critical role in regulating salinity stress tolerance. However, the response of soybean seedlings (Glycine max L.) to exogenous gamma-aminobutyric acid (GABA) under saline stress conditions has not been fully elucidated.