Rapid Synthesis of Primary Amides Using Ammonia Borane.

We report the rapid synthesis of primary amides by directly using commercially available ammonia borane (NH·BH), sodium hexamethyldisilazide (NaHMDS), and esters. The success of this protocol relies on NH·BH as the nitrogen source being considerably more convenient and NaHMDS being an excellent proton abstractor but not participating in the nucleophilic addition reaction. The reaction had a wide substrate scope containing bioactive molecules, and most of the substrates were efficiently amidated over 90% yields.

Impaired Iron-Sulfur Cluster Synthesis Induces Mitochondrial PARthanatos in Diabetic Cardiomyopathy.

Diabetic cardiomyopathy (DCM), a severe complication of diabetes, is characterized by mitochondrial dysfunction, oxidative stress, and DNA damage. Despite its severity, the intrinsic factors governing cardiomyocyte damage in DCM remain unclear. It is hypothesized that impaired iron-sulfur (Fe-S) cluster synthesis plays a crucial role in the pathogenesis of DCM.

Triborane (BH)-mediated regioselective substitution reactions of pyridine derivatives.

There exists an interplay between borane and a Lewis base in their adducts. However, studies on these adducts so far have mainly focused on the different reactions of B-H bonds with limited attention given to the influence of borane on the chemistry of the Lewis base, except for BF and BAr. Herein, we have synthesized novel borane adducts with pyridine derivatives, Py·BH, in which the coordination of BH efficiently achieved the intra-molecular charge transfer.

Interfacial delivery of carbon monoxide via smart titanium implant coating for enhanced soft tissue integration with switchable antibacterial and immunomodulatory properties.

Soft tissue integration around titanium (Ti) implants is weaker than that around natural teeth, compromising long-term success of Ti implants. Carbon monoxide (CO) possesses distinctive therapeutic properties, rendering it as a highly promising candidate for enhancing STI. However, achieving controlled CO generation at the STI interface remains challenging.

Sodium Octahydridotriborate as a Solid Electrolyte with Excellent Stability Against Sodium-Metal Anode.

Solid-state sodium metal batteries have been extensively investigated because of their potential to improve safety, cost-effectiveness, and energy density. The development of such batteries urgently required a solid-state electrolyte with fast Na-ion conduction and favorable interfacial compatibility. Herein, the progress on developing the NaBH solid-state electrolytes is reported, which show a liquid-like ionic conductivity of 0.

Unravelling the underlying mechanism of the reduction of aldehydes/ketones with metal borohydride in an aprotic solvent.

The reduction mechanism of aldehyde/ketones with M(BH) is not fully understood, even though the hydroboration mechanism of weak Lewis base borane complexes is known to involve a four-membered ring transition state. Herein, the reduction mechanism of M(BH) in aprotic solvents has been elucidated for a six-membered ring, in which hydride transfer to the C atom from the B atom, formation of an L·BH adduct, and disproportionation of (BH(OR)) borane are involved. The metal cations and solvents participate in and significantly influence the reaction procedure.

Hydrogen sulfide improves endothelial barrier function by modulating the ubiquitination degradation of KLF4 through TRAF7 S-sulfhydration in diabetic aorta.

Anomalous vascular endothelium significantly contributes to various cardiovascular diseases. VE-cadherin plays a vital role in governing the endothelial barrier. Krüppel-like factor 4(KLF4), as a transcription factor, which binds the VE-cadherin promoter and enhances its transcription.

Potassium Decahydrido--Decaborane Urea Complex as a Potential Solid-State Electrolyte for Potassium Metal Batteries.

All-solid-state potassium metal batteries have been considered promising candidates for large-scale energy storage because of abundance and wide availability of K resources, elimination of flammable liquid organic electrolytes, and incorporation of high-capacity K metal anode. However, unideal K-ion conductivities of most reported K-ion solid electrolytes have restricted the development of these batteries. Herein, a novel KBH·CO(NH) complex is reported, forming by incorporating urea into KBH, to achieve an enhanced K-ion conductivity.

Exogenous HS initiating Nrf2/GPx4/GSH pathway through promoting Syvn1-Keap1 interaction in diabetic hearts.

Excessive ROS accumulation contributes to cardiac injury in type 2 diabetes mellitus. Hydrogen sulfide (HS) is a vital endogenous gasotransmitter to alleviate cardiac damage in diabetic cardiomyopathy (DCM). However, the underlying mechanisms remain unclear.

Structure and characterization of Tremella fuciformis polysaccharides/whey protein isolate nanoparticles for sustained release of curcumin.

Background: Whey protein isolate (WPI) nanoparticles can be used in a strategy to improve the bioavailability of curcumin (CUR) although they are generally not stable. Previous studies have indicated that Tremella fuciformis polysaccharides (TFPs) can increase the stability of WPI. This work investigated systematically the characterization and structure of TFP/WPI nanoparticles with differing CUR content.

L-Theanine and Immunity: A Review.

L-theanine (N-ethyl-γ-glutamine) is the main amino acid in tea leaves. It not only contributes to tea flavor but also possesses several health benefits. Compared with its sedative and calming activities, the immunomodulatory effects of L-theanine have received less attention.

Correction: Liu et al. Exogenous HS Attenuates Hypertension by Regulating Renin Exocytosis under Hyperglycaemic and Hyperlipidaemic Conditions. 2023, , 1690.

In the original publication [...

Quality Chemistry, Physiological Functions, and Health Benefits of Organic Acids from Tea ().

Organic acids account for around 3% of the dry matter in tea leaves, and their composition and contents vary in different types of tea. They participate in the metabolism of tea plants, regulate nutrient absorption and growth, and contribute to the aroma and taste quality of tea. Compared with other secondary metabolites in tea, the researches on organic acids are still limited.

Exogenous HS Attenuates Hypertension by Regulating Renin Exocytosis under Hyperglycaemic and Hyperlipidaemic Conditions.

Obesity, along with type 2 diabetes mellitus (T2DM), is a major contributor to hypertension. The renin-angiotensin-aldosterone system is involved in the occurrence of diabetes and hypertension. However, the mechanism by which obesity is related to T2DM induced hypertension is unclear.

Silylium ion-mediated cage-opening functionalization of -BH salts.

The cage-opening functionalization of stable -BH salts is a great way to get various boron clusters. However, the known methods to mediate cage-opening functionalization rely on the use of strong acids, which suffer from low efficiency and narrow substrate scope. Herein, an efficient method to synthesize 6-substituted decaboranyl ethers and sulfides has been developed.

Histone Methyltransferase SETD2 Is Required for Porcine Early Embryonic Development.

SET domain-containing 2 (SETD2) is a methyltransferase that can catalyze the di- and tri-methylation of lysine 36 on histone H3 (H3K36me2/me3). SETD2 frequently mediates H3K36me3 modification to regulate both oocyte maturation and preimplantation embryonic development in mice. However, the specific substrate and function of SETD2 in porcine early embryonic development are still unclear.

Saponins from Seeds Stimulate GIP Secretion in Mice and STC-1 Cells via SGLT1 and TGR5.

Glucose-dependent insulinotropic polypeptide (GIP) is one of the important incretins and possesses lots of physiological activities such as stimulating insulin secretion and maintaining glucose homeostasis. The pentacyclic triterpenoid saponins are the major active ingredients in tea () seeds. This study aimed to investigate the effect of tea seed saponins on the GIP secretion and related mechanisms.

Synthesis, Formation Mechanism, and Structure of K[BHS(CH)BH] and Its Application in Preparation of KBH.

The design, synthesis, and applications of new boranes are eternal topics in boron chemistry. A new bis(borane)alkanethiolate salt, K[BHS(CH)BH], was synthesized in high yield by the reaction of K with (CH)S·BH at room temperature. The formation mechanism was elucidated based on experimental and theoretical studies.

Coordination mode and stability of the tetrahydroborate ligand in group 10 metal pincer complexes.

The coordination mode of the BH ligand in transition metal tetrahydroborate complexes is mainly dominated by the nature of the metal centres. However, other factors can also play important roles sometimes. In order to rationalize the coordination modes and the stability of the BH ligand in group 10 metal tetrahydroborate pincer complexes, [2,6-(BuPO)CH]Pt(η-HBH) and [CH--(NCHPBu)B]M(η-HBH) (M = Ni, Pt) were prepared and characterized.

Comparative Transcriptome and Phytochemical Analysis Provides Insight into Triterpene Saponin Biosynthesis in Seeds and Flowers of the Tea Plant ().

Triterpene saponins exhibit various biological and pharmacological activities. However, the knowledge on saponin biosynthesis in tea plants ( L.) is still limited.

Investigating changes of proteome in the bovine milk serum after retort processing using proteomics techniques.

The objective of this study was to investigate the changes of the proteins in bovine milk serum after retort processing by label-free quantification proteomics techniques. A total of 96 and 106 proteins were quantified in control group (CG) and retort group (RG), respectively. Hierarchical clustering analysis of the identified milk serum proteins showed a decrease in the abundance of most proteins, such as serum albumin, lactoperoxidase, lactotransferrin, and complement C3, and an increase in the abundance of other proteins such as κ-casein, lipocalin 2, and Perilipin.

Which Type of Pincer Complex Is Thermodynamically More Stable? Understanding the Structures and Relative Bond Strengths of Group 10 Metal Complexes Supported by Benzene-Based PYCYP Pincer Ligands.

The influence of the pincer platform composition and substitution on the reactivity and physical properties of pincer complexes can be easily explored through different experimental techniques. However, the influence of these factors on the molecular structures and thermodynamic stability of pincer complexes is usually very subtle and cannot always be unambiguously established. To rationalize this subtle influence, a survey of crystallographic data from 130 group 10 metal pincer complexes supported by benzene-based PYCYP pincer ligands, [2,6-(RPY)CHR']MX (Y = CH, NH, O, S; M = Ni, Pd, Pt; R = Bu, Pr, Ph, Cy, Me; R' = COMe, Bu, CF, Ac; = 0-2; X = F, Cl, Br, I, H, SH, SPh, SBn, Ph, Me, N, NCS), was carried out.