Exosomes have emerged as significant biomarkers for multiple diseases, including cancers. Circular RNAs (circRNAs), abundant in exosomes, are involved in regulating cancer development. However, the regulatory function and the underlying molecular mechanism of hsa_circ_0006906 (circSCP2) in colorectal cancer (CRC) metastasis remain unclear.
View Article and Find Full Text PDFThe electric conductivity and charge transport efficiency of metal-organic frameworks (MOFs) dictate the effective utilization of built-in redox centers and electrochemical redox kinetics and therefore electrochemical performance. Reticular chemistry and the tunable microcosmic shape of MOFs allow for improving their electric conductivity and charge transfer efficiency. Herein, we synthesized two Ni-MOFs (Ni-tdc-bpy and Ni-tdc-bpe) by the solvothermal reaction of Ni ions with 2,5-thiophenedicarboxylic acid (Htdc) in the presence of conjugated 4,4'-bipyridyl (bpy) and 1,2-di(4-pyridyl)ethylene (bpe) coligands, respectively.
View Article and Find Full Text PDFThe site-selective functionalization of cyclic amides provides an attractive protocol for the synthesis of valuable molecules. We report herein an electrochemical desaturation and β-thiocyanation of cyclic amides under external oxidant-free conditions. This method exhibits broad functional group tolerance, excellent selectivity, mild reaction conditions and can be applied for late-stage functionalization of bioactive molecules.
View Article and Find Full Text PDFBackground: The predictive importance of the stress hyperglycemia ratio (SHR), which is composed of admission blood glucose (ABG) and glycated hemoglobin (HbA1c), has not been fully established in noncardiac surgery. This study aims to evaluate the association and predictive capability the SHR for major perioperative adverse cardiovascular events (MACEs) in noncardiac surgery patients.
Methods: Individuals who underwent noncardiac surgical procedures between 2011 and 2020, including both diabetic and non-diabetic patients, were identified in the perioperative medicine database (INSPIRE 1.
Prolactin (PRL) has recently been found to play a role in lipid metabolism in addition to its traditional roles in lactation and reproduction. However, the effects of PRL on lipid metabolism in liver and adipose tissues are unclear. Therefore, we aimed to study the role of PRL on lipid metabolism in goats.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
Polymer dielectrics are essential for advanced electronics and electrical power systems, yet they suffer from low energy density (U) due to their low dielectric constant (K) and the inverse relationship between K and breakdown stength (E). Here a scalable approach utilizing the designed molecularly interpenetrating interfaces is presented to achieve all-organic dielectric polymers with high U and charge-dischage efficiency (η). Distinctive intermolecular interactions and microstructural changes, as demonstrated experimentally and theoretically, are introduced by the molecularly interpenetrating interfaces, resulting in simultaneous improvements in dielectric responses and mechanical strength while inhibiting electrical conduction - outcomes unattainable in conventional layered polymers.
View Article and Find Full Text PDFLenvatinib, a multi-target inhibitor of receptor tyrosine kinases, has been increasingly used in the treatment of advanced hepatocellular carcinoma (HCC). However, its association with renal adverse effects, including proteinuria and renal microvascular complications, was not fully understood in HCC patients. We reported a case of a 68-year-old male with a history of hypertension, diabetes mellitus, and hepatitis C virus (HCV) infection, diagnosed with primary HCC in 2015.
View Article and Find Full Text PDFThe objective of this study was to investigate the differences in the energy metabolites, immunity, antioxidant capacity, and rumen microbiota of ewes with different numbers of fetuses. Thirty healthy ewes were selected and divided into single- (SL, = 10), twin- (TL, = 10), and triplet-fetal (PL, = 10) ewes according to the number of fetuses. Sampling was carried out on days 21 (Q21) and 7 (Q7) before lambing.
View Article and Find Full Text PDFWell-controlled conjugation of distinct metal-organic frameworks (MOFs) with dissimilar components and structures into a multi-component MOF system is important for the design of myriad materials with structural complexity, integrated properties, and desired applications. Herein, we developed an interesting integration strategy that relies on intermolecular force, and which can overcome the difference in lattice parameters. The strategy uses the pre-formed MOF matrixes as seeds to direct the self-assembly of secondary MOF particles for the construction of hybrid MOFs.
View Article and Find Full Text PDFPurpose: Job satisfaction among faculty in standardized residency training programs has been underexplored. The objective of this study is to investigate job satisfaction among these faculty members and identify associated determinants.
Methods: An online cross-sectional survey was conducted with 4581 teachers in Heilongjiang Province from 18 to 30 May 2022, using a census method.
The issue of infrared image deblurring has been a significant concern. However, in some specific scenes, the current mainstream deblurring algorithms based on optimization or deep learning fail to provide satisfactory results. Aiming to address the ineffectiveness of deep learning methods due to the low-cost datasets' unavailability for specific scenes, we innovatively propose a relatively simple full-chain imaging degradation simulation method using ground-to-air aircraft infrared imaging scene as an example, which considers the effects of blur and noise caused by the atmosphere, imaging system, target motion and detector.
View Article and Find Full Text PDFIn this study, we focus on the designability and controllability of the interaction interface between secondary structures, and discover an important interface interaction between helical secondary structures by non-covalent synthesis along the helical axis. The formation of discrete heterochiral dimers consisting of left-handed helix and right-handed helix not only helps to discover nonclassical supramolecular chirality phenomena, but also enables controllable protein assembly. Highly ordered nanostructures were thus constructed using π-stacking dimerization of helical foldamers to control tetrameric avidin proteins.
View Article and Find Full Text PDFPsoriasis is a complex and chronic inflammatory disease. Current drugs help control the symptoms of psoriasis but make no cure, urging discovery of novel drugs. We report in this paper the discovery of new phosphodiesterase 4 (PDE4) inhibitors for treatment of psoriasis.
View Article and Find Full Text PDFIntroduction: Maize stalk rot (MSR), caused by , is the most serious soil borne disease in maize production, seriously affecting maize yield and quality worldwide. Microbial biocontrol agents are the best means of controlling MSR and reducing the use of chemical fungicides, such as spp.
Methods And Results: In the study, a soil-isolated strain B105-8 was identified as (accession No.
Eur J Clin Microbiol Infect Dis
October 2024
4',5,7-Trihydroxy-8-methoxyflavone is an anticancer monomer component isolated from the traditional Chinese medicine . 4',5-Dihydroxy-7-piperazinemethoxy-8-methoxy flavonoids (DMF) with good solubility and anti-tumor effects was obtained by chemical modification in the early stage. This study explored the mechanism by which DMF regulates the mitochondrial apoptosis of human hepatoma cells through Bcl-2-associated transcription factor 1 (Bclaf1).
View Article and Find Full Text PDFBackground: Spiroplasma eriocheiris has been proved to be a pathogen causing tremor disease of Eriocheir sinensis, it is also infectious to other aquatic crustaceans, resulting in a serious threat on the sustainable development of the aquaculture industry. S. eriocheiris is a helical-shaped microbe without a cell wall, and its motility is related to the cytoskeleton protein MreB which belongs to the actin superfamily and has five MreB homologs.
View Article and Find Full Text PDFThe effects of sucrose esters (SE) with varying hydrophilic-lipophilic balance (HLB) values (SE 11, 13, 15) and different concentrations (0.01, 0.1, 1.
View Article and Find Full Text PDFBRAFV600E-mutant metastatic colorectal cancer (mCRC) is associated with poor prognosis. The combination of anti-BRAF/anti-EGFR (encorafenib/cetuximab) treatment for patients with BRAFV600E-mutant mCRC improves clinical benefits; unfortunately, inevitable acquired resistance limits the treatment outcome, and the mechanism has not been validated. Here, we discovered that monoacylglycerol O-acyltransferase 3-mediated (MOGAT3-mediated) diacylglycerol (DAG) accumulation contributed to acquired resistance to encorafenib/cetuximab by dissecting a BRAFV600E-mutant mCRC patient-derived xenograft (PDX) model exposed to encorafenib/cetuximab administration.
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