Publications by authors named "Jiaxian Cui"
Background: Among all malignancies, colorectal cancer ranks third in incidence rate and second in mortality rate. Human beta-defensin-1 (hBD-1) has broad-spectrum antimicrobial properties, and it plays an important role in the tumor microenvironment. Circular ribonucleic acids (circRNAs) regulate the proliferation and progression of colorectal cancer cells via cancer-related signaling pathways.
View Article and Find Full Text PDFColorectal cancer (CRC) is one of the malignant tumors globally, with high morbidity and mortality rates. The mainstay treatment of CRC includes surgery, radiotherapy, and chemotherapy. However, these treatments are associated with a high recurrence rate, poor prognosis, and highly toxic side effects.
View Article and Find Full Text PDFArticle Synopsis
- Human β-defensin-1 (hBD-1) may help the immune system fight colorectal cancer by influencing the mTOR pathway and promoting autophagy in colon cancer cells (SW620).
- In experiments, hBD-1 reduced the growth of SW620 cells and showed a decrease in mTOR activity while increasing proteins associated with autophagy (Beclin1 and LC3II/I).
- Bioinformatics analysis identified seven lncRNAs linked to the mTOR pathway, with TCONS_00014506 being particularly important; inhibiting this lncRNA further enhanced hBD-1's effects on mTOR and autophagy.
Objective: To explore the role of p300 in the context of paclitaxel (PTX) resistance in triple-negative breast cancer (TNBC) cells, focusing on its interaction with the phosphoenolpyruvate carboxykinase 1 (PCK1)/adenosine monophosphate-activated protein kinase (AMPK) pathway.
Methods: The expression of p300 and PCK1 at the messenger ribonucleic acid (mRNA) level was detected using a quantitative polymerase chain reaction. The GeneCards and GEPIA databases were used to investigate the relationship between p300 and PCK1.