Regional Dietary Pattern Associated with the Risk of Hypertensive Dyslipidemia Multimorbidity in Chinese Elderly: Results from China Nutrition and Health Surveillance in 2015-2017.

This study investigated regional dietary patterns and their association with hypertensive dyslipidemia multimorbidity among older Chinese adults. Data from 13,809 individuals (aged ≥ 65 years) were extracted from the 2015-2017 China Nutrition and Health Surveillance. Hypertensive dyslipidemia multimorbidity was defined as concurrent hypertension and dyslipidemia.

Zinc finger protein ZC3H18 is abnormally expressed in esophageal cancer tissues and facilitates the proliferation of esophageal cancer cells.

Introduction: Esophageal cancer presents significant challenges due to the limited efficacy and severe side effects associated with conventional treatments. The identification of epigenetic regulatory molecules that are aberrantly expressed in tumors is crucial for elucidating the mechanisms underlying the development and progression of esophageal cancer.

Methods: We performed high-throughput methylation level analysis on cancerous and adjacent tissues from 25 patients, identifying the differentially methylated gene utilizing Bismark software and data from TCGA.

Ischemia-reperfusion injury induces ZBP1-dependent PANoptosis in endothelial cells.

Endothelial cells play a critical role in the pathophysiology of ischemia-reperfusion injury (IRI). Although previous studies have shown that IRI can activate PANoptosis, the underlying mechanisms remain unclear. Our research investigates how IRI induces PANoptosis in endothelial cells, aiming to identify protective strategies to safeguard these cells from PANoptosis triggered by IRI.

Predictive model for daily risk alerts in sepsis patients in the ICU: visualization and clinical analysis of risk indicators.

This study introduces a novel Transformer-based time-series framework designed to revolutionize risk stratification in Intensive Care Units (ICUs) by predicting patient outcomes with high temporal precision. Leveraging sequential data from the eICU database, our two-stage architecture dynamically captures evolving health trajectories throughout a patient's ICU stay, enabling real-time identification of high-risk individuals and actionable insights for personalized interventions. The model demonstrated exceptional predictive power, achieving a progressive AUC increase from 0.

Deep-learning tool for early identification of non-traumatic intracranial hemorrhage etiology and application in clinical diagnostics based on computed tomography (CT) scans.

Background: To develop an artificial intelligence system that can accurately identify acute non-traumatic intracranial hemorrhage (ICH) etiology (aneurysms, hypertensive hemorrhage, arteriovenous malformation (AVM), Moyamoya disease (MMD), cavernous malformation (CM), or other causes) based on non-contrast computed tomography (NCCT) scans and investigate whether clinicians can benefit from it in a diagnostic setting.

Methods: The deep learning model was developed with 1,868 eligible NCCT scans with non-traumatic ICH collected between January 2011 and April 2018. We tested the model on two independent datasets (TT200 and SD 98) collected after April 2018.

New insights into changes in ocular structural parameters in simulated hypobaric hypoxia.

Purpose: High altitude is the main area for human exploration, and human eye is an important organ for obtaining visual signals. The changes of ocular structural parameters in a simulated hypobaric hypoxia environment need to be clarified.

Methods: Measurements were taken at five altitudes ((1) ground, (2) 3500 m, (3) 4000 m, (4) 4500 m and (5) ground).

A cross-sectional study on white matter hyperitensity in patients at the initial diagnosis of neuropsychiatric SLE: Correlation with Clinical and Laboratory Findings.

Objectives: This study aimed to investigate the differences between neuropsychiatric systemic lupus erythematosus (NPSLE) patients with and without white matter hyperintensity (WMH) on magnetic resonance imaging (MRI) and to identify factors independently associated with the development of WMH in NPSLE.

Method: A comparative analysis was conducted on 84 NPSLE patients hospitalized at Peking University People's Hospital from 2015 to 2022 at the initial diagnosis of NPSLE. Patients were categorized based on the presence of WMH on brain MRI scans.

Nutrients regulation of skin cells from canines and cats via Wnt/β-catenin signaling pathway.

For pets, healthy hair not only represents their beautiful appearance, but also reflects their overall health status. Nutritional imbalance, skin parasites, and stress can all cause a large amount of hair loss in pets, leading to skin-related diseases and posing a threat to their health. So, it is very important to understand and find solutions to alleviate or treat pet hair loss.

Restrictive Heterointerfacial Delamination in Flexible Perovskite Photovoltaics Using a Bifacial Linker.

Flexible perovskite solar cells offer significant potential for portable electronics due to their exceptional power density. However, the commercialization of these devices is hampered by challenges related to mechanical flexibility, primarily due to inadequate adhesion between the perovskite absorber layer and the flexible substrate. Herein, this delamination issue is addressed by employing a bifacial linker, potassium benzyl(trifluoro)borate (BnBFK), to enhance adhesion at the SnO/perovskite interface.

Stroke Management and Analysis Risk Tool (SMART): An interpretable clinical application for diabetes-related stroke prediction.

Background And Aims: The growing global burden of diabetes and stroke poses a significant public health challenge. This study aims to analyze factors and create an interpretable stroke prediction model for diabetic patients.

Methods And Results: Data from 20,014 patients were collected from the Affiliated Drum Tower Hospital, Medical School of Nanjing University, between 2021 and 2022.

Dimethyl fumarate promotes the degradation of HNF1B and suppresses the progression of clear cell renal cell carcinoma.

Clear cell renal cell carcinoma (ccRCC) is the most lethal subtype of renal cancer, and its treatment options remain limited. Therefore, there is an urgent need to discover therapeutic agents for ccRCC treatment. Here, we demonstrate that dimethyl fumarate (DMF), an approved medication for multiple sclerosis [1] and psoriasis, can inhibit the proliferation of ccRCC cells.

Dystrophinopathy in the paravertebral muscle of adolescent idiopathic scoliosis: a prospective case-control study in China.

Study Design: A prospective case-control study.

Purpose: This prospective case-control study aimed to analyze the paravertebral muscle changes in patients with adolescent idiopathic scoliosis (AIS) and determine paravertebral myopathological changes associated with the clinical progression of AIS.

Overview Of Literature: The incidence of AIS is significant globally and worsens before bone maturation, causing a serious effect.

Effect of metformin on the level of aqueous humor inflammatory cytokines in patients with cataract.

This study investigated the content of inflammatory cytokines in the aqueous humor (AH) of cataract patients with type 2 diabetes (T2DM) and explored the effect of metformin on the level of cytokines. AH was collected from patients undergoing phacoemulsification and intraocular lens implantation in Peking University Third Hospital. Levels of cytokines were measured by Cytometric Bead Assay (CBA) Flex Set.

Comparison of three different in vitro digestion methods for carbohydrates.

Spectrophotometer method, ELISA, and High-performance anion exchange chromatography with pulsed amperometric detection (HPAEC-PAD) method have been widely used to quantify and characterize the glucose released from rice after in vitro digestion. Despite this, the results of the three methods may not be comparable. This work investigated the limitation of detection (LOD) and quantification (LOQ) of the glucose released after in vitro rice digestion.

Lipid droplets in central nervous system and functional profiles of brain cells containing lipid droplets in various diseases.

Lipid droplets (LDs), serving as the convergence point of energy metabolism and multiple signaling pathways, have garnered increasing attention in recent years. Different cell types within the central nervous system (CNS) can regulate energy metabolism to generate or degrade LDs in response to diverse pathological stimuli. This article provides a comprehensive review on the composition of LDs in CNS, their generation and degradation processes, their interaction mechanisms with mitochondria, the distribution among different cell types, and the roles played by these cells-particularly microglia and astrocytes-in various prevalent neurological disorders.

The Effect of 0.05D Interval Precise Refraction on Small-Incision Lenticule Extraction Surgery: A Retrospective Study with Short-Term Follow-Up.

Background: To compare the postoperative visual quality of patients undergoing small-incision lenticule extraction (SMILE) with spherical trial lens intervals of 0.05D and 0.25D in preoperative manifest refraction.

Tear cytokine levels in Sjogren's syndrome-related dry eye disease compared with non-Sjogren's syndrome-related dry eye disease patients: A meta-analysis.

Background: As a common complication of Sjogren syndrome (SS), SS-related dry eye disease (SS-DED) significantly affects the patients' quality of life. Pro-inflammatory cytokines in tears are widely believed to play a crucial role in the pathogenesis of SS-DED. A systematic literature review with meta-analyses was conducted to provide a quantitative summary of tear cytokine levels in SS-DED compared with non-SS-DED and healthy controls.

[Recycling of Reclaimed Water in China: Current Situation, Development Trend, and Countermeasures].

Recycling of reclaimed water is an important way to develop water resources and reduce pollution discharge. At present, the utilization rate of reclaimed water is low in China and the recycling system is inadequate. Therefore, from the perspective of "carbon peaking and carbon neutrality" dual carbon propulsion and "water resources protection, water environment governance, and water ecological restoration" three water co-governance, this study first systematically combined the water resources situation, water supply structure, urban domestic sewage collection and treatment, and recycling of reclaimed water in all provinces （municipalities and autonomous regions）.

Exploring lncRNA expression in follicular fluid exosomes of patients with obesity and polycystic ovary syndrome based on high-throughput sequencing technology.

Background: Infertility is a reproductive health problem that attracts worldwide attention. Polycystic ovary syndrome (PCOS) is a major cause of female infertility and patients with obesity and PCOS are particularly common in clinical practice. Long non-coding RNA (lncRNAs) are a functional core in cells that regulate gene expression, transcription, and chromatin modification processes, and participate in epigenetics, cell cycle, and cell differentiation.

Investigating the effects of simulated high altitude on colour discrimination.

Purpose: To quantify changes in colour vision immediately after exposure to different altitudes of low-pressure hypoxia.

Methods: The study involved 35 healthy participants (ages 20-26). Colour vision was assessed using the Farnsworth-Munsell 100-Hue test at eight different altitudes (condition 1: ground, condition 2: 3500 m, condition 3: 3500 m after 40 min, condition 4: 4000 m, condition 5: 4000 m after 40 min, condition 6: 4500 m, condition 7: 4500 m after 40 min, condition 8: back to the ground).

Functional Three-Dimensional Zeolitic Imidazolate Framework with an Ordered Macroporous Structure for the Isolation of Extracellular Vesicles.

Extracellular vesicles (EVs) and their cargoes are increasingly being recognized as noninvasive diagnostic markers, necessitating the isolation of EVs from complex biological samples. Herein, a distearoyl phospholipid ethanolamine-functionalized single-crystal ordered macroporous three-dimensional zeolitic imidazolate framework (SOM-ZIF-8-DSPE) was developed, which combines the surface charge interaction of ZIF-8 with the synergistic effect of DSPE insertion into the phospholipid membrane of EVs to improve the isolating selectivity of EV capture. The materials have porous structures larger than 300 nm in diameter, providing enough space and active sites to trap EVs.

Interpretable mortality prediction model for ICU patients with pneumonia: using shapley additive explanation method.

Background: Pneumonia, a leading cause of morbidity and mortality worldwide, often necessitates Intensive Care Unit (ICU) admission. Accurate prediction of pneumonia mortality is crucial for tailored prevention and treatment plans. However, existing mortality prediction models face limited adoption in clinical practice due to their lack of interpretability.

Structural analysis of the mitochondrial genome of Santalum album reveals a complex branched configuration.

Background: Santalum album L. is an evergreen tree which is mainly distributes throughout tropical and temperate regions. And it has a great medicinal and economic value.