Publications by authors named "Jiaxi Han"

Background: The most common cause of death in those with cystic fibrosis (CF) is respiratory failure due to bronchiectasis resulting from repeated cycles of respiratory infection and inflammation. Protease-activated receptor 1 (PAR1) is a cell surface receptor activated by serine proteases including neutrophil elastase, which is recognised as a potent modulator of inflammation. While PAR1 is known to play an important role in regulating inflammation, nothing is known about any potential role of this receptor in CF pathogenesis.

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Polysaccharides, key bioactive compounds derived from Chinese herbs, are increasingly recognized for their therapeutic potential in modulating gut microbiota to treat various diseases. However, their efficacy in alleviating mammary inflammation and oxidative stress and protecting the blood-milk barrier (BMB) compromised by Staphylococcus aureus (S. au) infection remains uncertain.

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  • This study focuses on the role of Caseinolytic Protease B (ClpB) in tomato plants, highlighting its importance in adapting to high temperatures and promoting plant development.* -
  • Researchers identified six specific ClpB genes across four chromosomes in tomatoes and discovered that certain gene pairs resulted from past duplication events.* -
  • Expression analysis revealed that several ClpB genes were significantly activated in different tomato tissues during heat stress, particularly in fruit, flower buds, and seedlings, suggesting their key role in the plant's heat response.*
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  • Photodynamic therapy (PDT) is a promising cancer treatment known for its precise targeting, low invasiveness, and minimal side effects, but faces challenges like delivering drugs to tumors and overcoming low oxygen levels.
  • Research is concentrating on innovative solutions like nanoplatforms and combination therapies, with reactive oxygen species (ROS)-responsive polymeric micelles showing potential for improved cancer treatment.
  • The study introduces ROS-responsive micelles (TC@PTP) that co-load a porphyrin derivative and capsaicin, which enhance drug delivery and reduce tumor hypoxia, ultimately boosting the efficacy of PDT against melanoma.
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  • - The study assessed the impact of saline perfusion before catheter removal on patients with benign prostatic hyperplasia (BPH) who underwent GreenLight laser treatment, involving 200 patients split into perfusion and control groups.
  • - Results showed that the perfusion group experienced significantly shorter waiting times for first urination, higher satisfaction ratings, and reduced anxiety compared to the control group, along with lower white blood cell counts post-removal.
  • - The findings suggest that saline perfusion can enhance recovery outcomes after catheter removal without increasing adverse events.
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As carbon dioxide (CO) adsorbents, porous materials with high specific surface areas and abundant CO-philic groups always exhibit high CO capacities. Based on this consensus, a category of oxygen-rich macroporous carbon foams was fabricated from macroporous resorcinol-formaldehyde resins (PRFs), which were obtained via an oil-in-water concentrated emulsion. By the active effect of potassium hydroxide (KOH) at high temperatures, the resultant carbon foams (ACRFs) possessed abundant micropores with rich oxygen content simultaneously.

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To determine the role of lamin B1 (LMNB1) in the progression and metastasis of primary prostate cancer (PC). Two PC cohorts were used to investigate the clinical relationship between expression and tumor progression and metastasis. The qRT-PCR results revealed that expression was markedly increased in patients with aggressive features and was associated with worse prognosis.

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Developing a highly active and cost-effective cathode electrocatalyst with strong stability for oxygen reduction reaction (ORR) is extremely necessary. In this work, we reported a facile synthetic path to prepare a hybrid nanostructure formed of nitrogen-doped Ketjenblack carbon (N-KC) supported CoO nanoparticles (CoO/N-KC), which could be used as a promising and stable electrocatalyst for ORR. Compared with the physical mixture of CoO and N-KC and pure N-KC samples, the resulting CoO/N-KC nanohybrid afforded remarkably superb ORR activity with a half-wave potential of 0.

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Background: Proteolytic cleavage of protease-activated receptor 1 (PAR1) can result in potent downstream regulatory effects on inflammation. Although PAR1 is expressed throughout the gastrointestinal tract and activating proteases are increased in inflammatory bowel disease, the effect of PAR1 activation on colitis remains poorly understood, and has not previously been studied in pediatric disease.

Methods: Expression of PAR1 and inflammatory cytokines in colonic biopsies from pediatric patients with Crohn's disease exhibiting active moderate to severe colitis was measured by quantitative PCR.

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ASBTRACT Heat shock protein Complex (HspC) vaccines are composed of Hsp purified from pathogenic bacteria along with their chaperoned protein cargo. Mouse studies have shown that HspC vaccines can induce a strong immune response against pathogenic bacteria without addition of an exogenous adjuvant. These vaccines are now entering clinical trials.

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A β-cyclodextrin (β-CD) functionalized polystyrene porous monolith was prepared by the following procedure: First, β-CD was modified with allyl bromide leading to allyl-β-cyclodextrin (allyl-β-CD); then a concentrated emulsion was prepared using a mixture of allyl-β-CD, styrene, and divinyl benzene as the continuous phase and water as the dispersed phase. In the third step, a β-cyclodextrin (β-CD) functionalized polystyrene porous monolith was obtained by copolymerization of allyl-β-CD and styrene followed by removal of the water phase. Since the allyl-β-CD contained both hydrophilic and hydrophobic groups, it tended to move towards the water/oil interface.

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The interfacial functionalized poly (glycidyl methacrylate) (PGMA) porous monolith was fabricated and applied as a novel porous adsorbent for copper ions (Cu(2+)). PGMA porous material with highly interconnected pore network was prepared by concentrated emulsion polymerization template. Then polyacrylic acid (PAA) was grafted onto the interface of the porous monolith by the reaction between the epoxy group on PGMA and a carboxyl group on PAA.

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Background: The development of a vaccine against the human gastric pathogen Helicobacter pylori, the main causative agent of gastric adenocarcinoma, has been hampered by a number of issues, including the lack of a mucosal adjuvant for use in humans. Heat shock proteins (Hsp), highly conserved molecules expressed by both bacteria and mammalian species, possess a range of functions, including acting as chaperones for cellular proteins and the ability to activate innate immune receptors. Hsp complex (HspC) vaccines, containing Hsp derived from pathogenic bacteria, are immunostimulatory without addition of an exogenous adjuvant and can induce immunity against their chaperoned proteins.

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