Application characteristics and clinical effectiveness of clinical finding staging in guiding non-surgical treatment of knee osteoarthritis involving 92 medical institutions.

Background: Accumulating evidence suggests that the radiographic phenotypes of patients with knee osteoarthritis (KOA) often do not correlate with their clinical findings, which are the primary reason for seeking medical care. Therefore, at OARSI 2024, we proposed a clinical finding staging system-Chinese medicine staging (CMS)-to guide the treatment of KOA. However, the clinical effectiveness and application characteristics of CMS in guiding non-surgical treatment of KOA remain unclear.

Photocatalytic Mechanisms of Organic Thermally Activated Delayed Fluorescence Compounds.

Reverse intersystem crossing (RISC) has become possible by minimizing the energy gap between the first excited singlet (S) and triplet state (T), which facilitates the thermally activated delayed fluorescence (TADF). Due to the small singlet-triplet energy gap, the S and T states exhibit comparable redox reactivity, leading organic TADF compounds to be potent photocatalysts. Here, we report such TADF compounds with multiple donor units designed as an efficient photocatalyst for the direct C(sp)-H carbamoylation of saturated aza-heterocycles.

Response of aquatic ecosystems multi-trophic biological communities under multiple pollutants stress.

Industrialization has significantly polluted the Yangtze River Basin, posing phenolic compounds and heavy metals that threaten ecological and human health. This study comprehensively evaluated the impact of these pollutants on the Yangtze River's aquatic ecosystems across multiple trophic levels. Sampling from 84 sites during both dry and wet seasons, water chemistry and biological data were analyzed by advanced molecular and statistical techniques.

Response of phytoplankton community to dissolved organic matter composition and lake trophic state.

Human activities, intensified urbanization and climate changes altered source and quantity of dissolved organic matter (DOM), complicating its interaction with phytoplankton in aquatic ecosystems. However, relationship between DOM and phytoplankton in urban lakes strongly disturbed by human activities was still unclear. Thus, a whole-year sampling campaign was conducted in the Tangxun Lake, China's largest urban lake, to reveal the interaction between DOM and phytoplankton.

Facial Amphiphile-Modified Lipids Highly Sensitize Liposomes toward Secretory Phospholipase A.

Upregulated secretory phospholipase A (sPLA) in tumors has been proposed as a stimulus to trigger drug release from liposomes for therapeutic effects. However, the current strategy for developing sPLA-responsive liposomes merely considering substrate preference suffers from limited membrane disruptive effects induced by enzymatic hydrolysis and safety issues resulting from the overuse of sPLA-preferred lipids. Here, a membrane-destabilizing mechanism based on enzymatic extraction and the transition of facial amphiphiles (FAs) within lipid membranes was introduced.

Ultrafast Charge Separation Driven by Solvation-Coupled Intramolecular Torsion.

Photoinduced intramolecular charge separation in a pyrene- and triarylamine-based donor-acceptor dyad was studied by polarization-dependent femtosecond time-resolved transient absorption (TA) spectroscopy in polar solvents. Photoexcitation forms an excited state with charge transfer (CT) character due to the intrinsic electronic coupling between the triarylamine and pyrene groups, resulting in ultrafast charge separation (CS) in polar solvents. TA measurements reveal a correlation between the rate of CS and solvation dynamics, which implies that solvation is involved in the CS reaction.

Versatile Keratin Fibrous Adsorbents with Rapid-Response Shape-Memory Features for Sustainable Water Remediation.

Biodegradable shape-memory polymers derived from protein substrates are attractive alternatives with strong potential for valorization, although their reconstruction remains a challenge due to the poor processability and inherent instability. Herein, based on Maillard reaction and immobilization, a feather keratin fibrous adsorbent featuring dual-response shape-memory is fabricated by co-spinning with pullulan, heating, and air-assisted spraying ZIF-8-NH. Maillard reaction between the amino group of keratin and the carbonyl group of pullulan improves the mechanics and thermal performance of the adsorbent.

Health-related quality of life assessed by EQ-5D-5L and its determinants among Chinese adults.

Background: Due to the rising standard of living and advances in public health and medical care in recent years in China, the health-related quality of life (HRQoL) has been increasingly acknowledged as an important part of health management of adults. This study aimed to analyze the HRQoL of Chinese adults and identify the influencing factors, proposing specific recommendations for improvement.

Methods: A cross-sectional study was conducted among 1,291 selected adults from four provinces spanning different regions in China aged ≥18 years from July 2021 and January 2022.

Review on effects and mechanisms of plant-derived natural products against breast cancer bone metastasis.

Bone metastasis is the prevalent form of metastasis in breast cancer, resulting in severe pain, pathological fractures, nerve compression, hypercalcemia, and other complications that significantly impair patients' quality of life. The infiltration and colonization of breast cancer (BC) cells in bone tissue disrupt the delicate balance between osteoblasts and osteoclasts within the bone microenvironment, initiating a vicious cycle of bone metastasis. Once bone metastasis occurs, conventional medical therapy with bone-modifying agents is commonly used to alleviate bone-related complications and improve patients' quality of life.

A FAPα-activated MRI nanoprobe for precise grading diagnosis of clinical liver fibrosis.

Molecular imaging holds the potential for noninvasive and accurate grading of liver fibrosis. It is limited by the lack of biomarkers that strongly correlate with liver fibrosis grade. Here, we discover the grading potential of fibroblast activation protein alpha (FAPα) for liver fibrosis through transcriptional analysis and biological assays on clinical liver samples.

Enhanced human activities since 20th century in pearl river delta, southern China: Evidence from high-resolution sedimentary records of polycyclic aromatic hydrocarbons and synthetic musks.

To understand the environmental impact of anthropogenic activities, the high-resolution temporal and compositional variations of polycyclic aromatic hydrocarbons (PAHs), oxygenated PAHs, and synthetic musks, related to human activities were investigated in a sediment core taken from the Pearl River Estuary, southern China. The temporal trend of the target compounds was evidence of the considerable impact of anthropogenic activities in the Pearl River Delta. Two significant increases of the target compounds levels in the sediment core were aligned with two nodes of key periods of economic development in China, namely, the foundation of People's Republic of China (1950s) and China's accession to the World Trade Organization (2000s).

Coupled effects of Fenton-like systems with different concentrations of HO/Biochar on diethyl phthalate removal: Dominant role of environmental persistent free radicals (EPFRs).

To investigate the impact of different HO concentrations on the Fenton-like systems of HO/biochar, this study examined the mechanism of the physical structure and environmental persistent free radicals (EPFRs) of biochar during diethyl phthalate (DEP) removal by the Fenton-like system. The peak-splitting method was utilized to differentiate EPFRs types in cotton stalk biochar produced at different temperatures. High-temperature environments promote π-electron delocalization, which facilitates phenyl π free radicals and σ-π oxygen-containing free radicals.

Visible light photocatalytic degradation of oxytetracycline hydrochloride using chitosan-loaded Z-scheme heterostructured material BiOCOOH/O-gCN.

In this work, a Z-scheme heterostructured BiOCOOH/O-gCN material was synthesized and immobilized on chitosan (CTS) to obtain the BiOCOOH/O-gCN/CTS photocatalytic material for photocatalytic degradation of oxytetracycline hydrochloride (CTC).Our findings indicate that the composite material BiOCOOH/O-gCN, as well as the BiOCOOH/O-gCN/CTS composite membrane, displayed a significantly higher efficiency in photocatalytic degradation of CTC compared to BiOCOOH alone, owing to the synergistic effect of adsorption and photocatalysis. Following four cycles of use, the composite material retained around 96 % of its initial photocatalytic degradation activity.

Clinically Available and Reproducible Prediction Models for IDH and CDKN2A/B Gene Status in Adult-type Diffuse Gliomas.

Purpose: Isocitrate dehydrogenase (IDH) and cyclin-dependent kinase inhibitor (CDKN) 2A/B status holds important prognostic value in diffuse gliomas. We aimed to construct prediction models using clinically available and reproducible characteristics for predicting IDH-mutant and CDKN2A/B homozygous deletion in adult-type diffuse glioma patients.

Materials And Methods: This retrospective, two-center study analysed 272 patients with adult-type diffuse glioma (230 for primary cohort and 42 for external validation cohort).

Novel Evolution of Mineralocorticoid Receptor in Humans Compared to Chimpanzees, Gorillas, and Orangutans.

We identified five distinct full-length human mineralocorticoid receptor (MR) genes containing either 984 amino acids (MR-984) or 988 amino acids (MR-988), which can be distinguished by the presence or absence of Lys, Cys, Ser, and Trp (KCSW) in their DNA-binding domain (DBD) and mutations at codons 180 and 241 in their amino-terminal domain (NTD). Two human MR-KCSW genes contain either (Val-180, Val-241) or (Ile-180, Val-241) in their NTD, and three human MR-984 genes contain either (Ile-180, Ala-241), (Val-180, Val-241), or (Ile-180, Val-241). Human MR-KCSW with (Ile-180, Ala-241) has not been cloned.

A Review of -(1,3-Dimethylbutyl)-'-phenyl--Phenylenediamine (6PPD) and Its Derivative 6PPD-Quinone in the Environment.

As an antioxidant and antiozonant, -(1,3-Dimethylbutyl)-'-phenyl--phenylenediamine (6PPD) is predominantly used in the rubber industry to prevent degradation. However, 6PPD can be ozonated to generate a highly toxic transformation product called -(1,3-Dimethylbutyl)-'-phenyl--phenylenediamine quinone (6PPD-quinone), which is toxic to aquatic and terrestrial organisms. Thus, 6PPD and 6PPD-quinone, two emerging contaminants, have attracted extensive attention recently.

Recycling scale inhibitor wastes into pH-responsive complexes to treat wastewater produced from spent lithium-ion battery disposal.

A large amount of organophosphorus-containing wastewater is produced in spent lithium-ion battery disposal. Forward osmosis (FO) offers unique advantages in purifying this kind of wastewater if suitable draw solutes - the core of FO technology, are available. Herein we synthesize several pH-sensitive zinc complexes, namely ZnATMP-iNa (i = 0, 1, 2, 3, 4), from ZnSO and amino tris(methylene phosphonic acid) (ATMP) obtained from scale inhibitor wastes for organophosphorus-containing wastewater remediation.