Broad-spectrum antivirals (BSAs) possess unique advantages of being effective against a wide range of both existing and unpredictable emerging viral infections. The host type I interferon (IFN) response serves as a universal defense against diverse viral infections nonspecifically, providing attractive targets to develop novel BSAs. In this study, we identified the flavonoid kaempferide as an enhancer of the type I IFN activated Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway, promoting the expression of IFN stimulated genes (ISGs) and the establishment of cellular antiviral status.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
March 2025
The mechanotransduction (MT) channel expressed in cochlear and vestibular hair cells converts the mechanical stimulation of sound and head movements into electrochemical signals. Recently, TMC1 and TMC2 (TMC1/2) have been recognized as the pore-forming subunit of the MT channel, but TMC1/2 functional expression in heterologous cells-which is critical for unequivocally identifying them as the bona fide pore-forming subunit of the MT channel-has not been achieved because ectopic TMC1/2 become trapped in the ER. Here, we report that adding a Fyn lipidation tag to mouse TMC1/2 (mTMC1/2) drove their cell-surface expression, and, importantly, full-length mTMC1/2 expressed alone functioned as mechanosensitive channels, underscoring the view that TMC1/2 constitute the sole pore-forming subunit of the MT channel.
View Article and Find Full Text PDFIntroduction: With the growing demand for skin-enhancing products in the market, research into edible plants has expanded significantly. Numerous studies have shown that plant extracts rich in phytochemicals can effectively improve skin issues such as wrinkles, pigmentation, and dullness. However, clinical studies focusing on the effects of combined ingredients are still limited.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
The designability and high reactivity of nanotechnology provide strategies for antitumor therapy by regulating the redox state in tumor cells. Here, we synthesize a kind of vanadium dioxide nanoparticle encapsulated in bovine serum albumin and containing disulfide bonds (VSB NPs) for photothermal-enhanced ferroptosis and pyroptosis effects. Mechanism studies show that disulfide bonds can effectively consume overexpressed glutathione (GSH) in the tumor microenvironment, leading to a decrease in glutathione peroxidase 4 (GPX4) activity.
View Article and Find Full Text PDF[n]Peri-acenes ([n]PA) have attracted great interest as promising candidates for nanoelectronics and spintronics. However, the synthesis of large [n]PA (n > 4) is extremely challenging due to their intrinsic open-shell radical character and high reactivity. Herein, we report the successful synthesis and isolation of a derivative (1) of peri-hexacene in crystalline form.
View Article and Find Full Text PDFNutrient pollution intensifies the strain on coastal ecosystems globally. Despite wetlands' significant nutrient removal potential, process-based assessments of nutrient removal in large-scale coastal wetlands face limitations that hinder accurate quantification of water quality improvements. This study proposes a novel quantitative approach by developing a coupled hydrodynamic-water quality-wetland biogeochemical model.
View Article and Find Full Text PDFHuman activities have intensified the global challenge of coastal eutrophication. Recently, water resource managers have encountered difficulties in formulating precise pollutant reduction strategies to mitigate coastal eutrophication. Despite the recognized importance of coastal wetlands and pollution sources in influencing coastal nutrient levels, accurately quantifying their impact remains difficult.
View Article and Find Full Text PDFMaterials (Basel)
August 2024
Biofouling poses a significant challenge to the marine industry, and silicone anti-biofouling coatings have garnered extensive attention owing to their environmental friendliness and low surface energy. However, their widespread application is hindered by their low substrate adhesion and weak static antifouling capabilities. In this study, a novel silicone polymer polydimethylsiloxane (PDMS)-based poly(urea-thiourea-imine) (PDMS-PUTI) was synthesized via stepwise reactions of aminopropyl-terminated polydimethylsiloxane (APT-PDMS) with isophorone diisocyanate (IPDI), isophthalaldehyde (IPAL), and carbon disulfide (CS).
View Article and Find Full Text PDFNanocomposite polymer coatings are being used as a new generation of marine antibiofouling coatings because of their toxin-free chemical composition and ease of large-scale adoption. Cellulose nanocrystal (CN) exhibits significant potential for composite reinforcement. Herein, CN was surface-modified via α,ω-bis(3-(2-hydroxyl-terminated polydimethylsiloxane (HTPDMS), resulting in dihydroxyl-terminated poly(dimethylsiloxane)-grafted CN (HP-g-CN).
View Article and Find Full Text PDFSevere fever with thrombocytopenia syndrome virus (SFTSV) is an emerging bunyavirus that causes severe viral hemorrhagic fever and thrombocytopenia syndrome with a fatality rate of up to 30%. No licensed vaccines or therapeutics are currently available for humans. Here, we develop seven monoclonal antibodies (mAbs) against SFTSV surface glycoprotein Gn.
View Article and Find Full Text PDFCoS/CeO, exhibiting the 3d-4f orbital coupling effect, is developed and shows exceptional OER activity, with an overpotential of 140 mV at 10 mA cm. DFT calculation and Raman spectra show the existence of a d-p-f electron transport ladder that can accelerate electron transfer through the Co-O(S)-Ce bond, optimize the adsorption free energy, and enhance the catalytic activity.
View Article and Find Full Text PDFIn this paper, a novel method was proposed for the synthesis of CuS on copper mesh via electrolysis in SRB culture medium. It was found that following electrolysis in SRB medium, squamous-like CuS arrays were obtained on the copper mesh, and the CuS loading contents varied with the electrolyzing parameters. The resultant CuS on copper mesh in SRB (CSCM-SRB) with the highest catalytic MB degradation properties was produced by electrolysis at 3.
View Article and Find Full Text PDFPhotocatalytic MoS with visible light response is considered as a promising bactericidal material owing to its non-toxicity and high antibacterial efficiency. However, photocatalysts always exist as powder, so it is difficult to settle photocatalysts on the metal surface, which limits their application in aqueous environments. To solve this problem, ultrasound and sodium dodecyl sulfate (SDS) were introduced into the co-deposition process of MoS and zinc matrix, so that novel MoS-Zn coatings were obtained.
View Article and Find Full Text PDFHerein, a N-doped carbon-supported Co and NiFe LDH (Co-NC@NiFe LDH) array was developed, which demonstrated superior catalytic activities for both the OER and UOR in an alkaline medium. The intrinsic electron transfer is effectively regulated by the construction of a built-in electric field, which reduces the reaction energy barrier and consequently leads to a significant enhancement in electrocatalytic activity.
View Article and Find Full Text PDFClin Transl Radiat Oncol
March 2024
This study evaluated the feasibilities and outcomes following four-dimensional magnetic resonance imaging (4D-MRI) assisted stereotactic body radiation therapy (SBRT) for unresectable colorectal liver metastases (CRLMs). From March 2018 to January 2022, we identified 76 unresectable CRLMs patients with 123 lesions who received 4D-MRI guided SBRT in our institution. 4D-MRI simulation with or without abdominal compression was conducted for all patients.
View Article and Find Full Text PDFThis erratum reports corrections for the original publication, Appl. Opt.61, 2834 (2022)APOPAI0003-693510.
View Article and Find Full Text PDFSimple, commercially available iodine was successfully employed as a highly efficient and chemoselective catalyst for the oxidative annulation of β,γ-unsaturated hydrazones to produce 1,6-dihydropyridazines under mild conditions for the first time. Interestingly, when active β,γ-unsaturated hydrazone compounds containing electron-donating groups, such as furyl, thienyl, and cycloalkyl, were used, pyrroles were obtained. A gram-scale preparation experiment and further derivatization of pyridazines demonstrated the potential applicability of our synthesis method.
View Article and Find Full Text PDFA V-doped amorphous/crystalline heterostructure of NiFe (oxy)hydroxide with nanoflower morphology is developed, which exhibits excellent OER and UOR catalytic activities. V doping changes the local charge density, lowers the reaction barrier, and optimizes the electron arrangement of the NiFe LDH catalyst.
View Article and Find Full Text PDFAlthough the fates of microplastics (0.1-5 mm) in marine environments and freshwater are increasingly studied, little is known about their vector effect in wastewater treatment plants (WWTPs). Previous studies have evaluated the accumulation of antibiotic resistance genes (ARGs) on microplastics, but there is no direct evidence for the selection and horizontal transfer of ARGs on different microplastics in WWTPs.
View Article and Find Full Text PDFIt is widely recognized that designing a special micro/nanostructure of microwave absorption materials for enhancing interface polarization benefits dielectric loss capability. In this work, a facile charge-driven self-assembly strategy is reported to prepare wrinkled reduced graphene oxide wrapped polymer-derived carbon (CS@rGO) microspheres. Noticeably, the unique three-dimensional (3D) multi-interface structure imparts CS@rGO microspheres with promoted microwave absorption capability.
View Article and Find Full Text PDFFe, Mo-doped NiS nanosheets that are derived from NiFe-LDH by structural transformation have been successfully developed. The obtained Fe, Mo-NiS exhibits a low overpotential of 67 mV to enable a current density of 10 mA cm for the HER and the overpotential for the OER is only 240 mV. Besides, the current density of 10 mA cm can be achieved with a voltage of 1.
View Article and Find Full Text PDFBackground: Chronic inflammatory disorders in atrial fibrillation (AF) contribute to the onset of ischemic stroke. Systemic immune inflammation index (SIII) and system inflammation response index (SIRI) are the two novel and convenient measurements that are positively associated with body inflammation. However, little is known regarding the association between SIII/SIRI with the presence of AF among the patients with ischemic stroke.
View Article and Find Full Text PDFOwing to the general disadvantages of traditional neural networks in gas concentration inversion, such as slow training speed, sensitive learning rate selection, unstable solutions, weak generalization ability, and an ability to easily fall into local minimum points, the extreme learning machine (ELM) was applied to sulfur hexafluoride () concentration inversion research. To solve the problems of high dimensionality, collinearity, and noise of the spectral data input to the ELM network, a genetic algorithm was used to obtain fewer but critical spectral data. This was used as an input variable to achieve a genetic algorithm joint extreme learning machine (GA-ELM) whose performance was compared with the genetic algorithm joint backpropagation (GA-BP) neural network algorithm to verify its effectiveness.
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