Autism-associated neuroligin 3 deficiency in medial septum causes social deficits and sleep loss in mice.

Patients with autism spectrum disorder (ASD) frequently experience sleep disturbance. Genetic mutations in the neuroligin 3 (NLG3) gene are highly correlative with ASD and sleep disturbance. However, the cellular and neural circuit bases of this correlation remain elusive.

Visualization of nasal powder distribution using biomimetic human nasal cavity model.

Nasal drug delivery efficiency is highly dependent on the position in which the drug is deposited in the nasal cavity. However, no reliable method is currently available to assess its impact on delivery performance. In this study, a biomimetic nasal model based on three-dimensional (3D) reconstruction and three-dimensional printing (3DP) technology was developed for visualizing the deposition of drug powders in the nasal cavity.

Particle Design and Inhalation Delivery of Iodine for Upper Respiratory Tract Infection Therapy.

Diseases caused by upper respiratory tract (URT) and pulmonary infections have been a serious threat to human health for millennia and lack of targeted effective therapeutic techniques. In this study, two kinds of cyclodextrin particles with typical particle shapes of nanocubes and microbars were synthesized through a facile process. Subsequently, the particles were used as carriers for loading and stabilizing iodine and characterizations were performed to demonstrate the loading mechanism.

Interactions of Muscovy duck reovirus, gut microbiota, and host innate immunity: Transcriptome and gut microbiota analysis.

It has been shown that Muscovy duck reovirus (MDRV) infection causes severe intestinal barrier damage and intestinal mucosal immune suppression. The health and balance of gut microbes is essential for the progression of intestinal infectious diseases. To investigate the interaction of MDRV, intestinal bacteria with host intestinal innate immunity, an MDRV contact-infection model was established in this study.

Analysis of Nonlinear Transient Energy Effect on Thermoelectric Energy Storage Structure.

In complex flight conditions, due to the large amount of unusable heat generated by aerodynamic heating, the thermal protection system of an aircraft needs to withstand a large temperature shock, which brings great challenges to the design of the structure. In order to effectively utilize the irregular aerodynamic heat, and improve structural heat conduction, a composite structure is formed by using phase change energy storage materials on the basis of the thermoelectric structure, which transforms the aerodynamic waste heat into stable electric energy for the internal system. Through the study of the response of nonlinear transient energy, it is found that the thermoelectric and mechanical properties of the new structure can be improved by adding phase change energy storage materials.

Molecularly imprinted electrochemical sensor based on Au nanoparticles in carboxylated multi-walled carbon nanotubes for sensitive determination of olaquindox in food and feedstuffs.

A novel molecularly imprinted electrochemical sensor (MIECS) was proposed to determine olaquindox (OLA) using gold nanoparticles in molecularly imprinted polymer (AuNPs@MIP) and carboxylated multi-walled carbon nanotubes (cMWCNTs). Glassy carbon electrode (GCE) was modified with cMWCNTs (cMWCNTs/GCE), and AuNPs/cMWCNT/GCE was obtained by electrodeposition on cMWCNTs/GCE using chronoamperometry in HAuCl. Then, the obtained MIP/AuNPs/cMWCNTs/GCE was electropolymerized using OLA as template and o-PD as monomer to determine OLA.