Starfish-Inspired Synergistic Reinforced Hydrogel Wound Dressing: Dual Responsiveness and Enhanced Bioactive Compound Delivery for Advanced Skin Regeneration and Management.

Effective wound management demands advanced dressings that protect while actively supporting healing. Traditional wound dressings often fall short of meeting the complex needs of skin repair. Inspired by the regenerative abilities of starfish, we developed a bionically engineered hydrogel designed to enhance wound healing.

Highly Strained Electron-Rich Molecular Bowl and Nanographene.

Introducing two pyrrole rings at the armchair edges of perylene creates the small, electron-rich molecular bowl 1, which can be viewed as a nitrogen-doped end-cap of C. Despite numerous attempts since 2008, its synthesis has been hindered by strain and synthetic challenges. In this study, we present the synthesis and property analysis of molecular bowl 1 and its dimer, the wavy-shaped nanographene 2.

Development and Validation of the Particle into Nitroxide Quencher System with BPEAnit Probe for High-Sensitivity Reactive Oxygen Species Detection in Atmospheric Monitoring.

Reactive oxygen species (ROS) play an important role in atmospheric pollution, and their detection is essential for assessing air quality and health risks. This study developed and validated a standardized methodology for using the BPEAnit probe in a specially designed particle-into-liquid sampler, the Particle Into Nitroxide Quencher (PINQ), to measure reactive oxygen species in atmospheric monitoring applications. The method demonstrated high sensitivity, with a detection limit of 0.

Combination of potassium oxonate with anti-PD-1 for the treatment of colorectal cancer.

Introduction: Identification of effective therapies for colorectal cancer (CRC) remains an urgent medical need, especially for the microsatellite stable (MSS) phenotype. In our previous study, potassium oxonate (PO), a uricase inhibitor commonly used for elevating uric acid in mice, unexpectedly showed remarkable inhibition of tumor growth when combined with anti-programmed death-1 (PD-1). Further research demonstrated that the combination of potassium oxonate and anti-PD-1 could reprogram the immune microenvironment.

Cooperative Magnetic Interfacial Microrobot Couplefor Versatile Non-Contact Biomedical Applications.

Magnetic interfacial microrobots are increasingly recognized as a promising approach for potential biomedical applications ranging from electronic functionalization to minimally invasive surgery and targeted drug delivery. Nevertheless, existing research faces challenges, including less cooperative interactions, contact-based cargo manipulation, and slow transport velocity. Here, the cooperative magnetic interfacial microrobot couple (CMIMC) is proposed to address the above challenges.

Microplastics Exposure Causes the Growth Hormone Resistance on the Stem Cell.

With the large range of applications for plastic products, the potential hazards of polystyrene microplastics (PS-MPs) as a hazardous substance have been widely concerned. Mesenchymal stem cells (MSCs) are important cells in the body with high self-renewal ability, multidirectional differentiation potential and low immunogenicity. Growth hormone (GH) has important biological regulatory effects on MSCs.

Genomic landscape and potential therapeutic targets in alpha-fetoprotein-producing gastric cancer.

Alpha-fetoprotein-producing gastric carcinoma (AFPGC) is a rare and aggressive subtype of gastric cancer (GC). A comprehensive analysis of clinicopathological features, immunophenotypes, molecular characteristics, and survival in AFPGC contributes to identifying potential therapeutic targets and developing new strategies to manage this disease. A retrospective cohort study was conducted at Shanxi Cancer Hospital from January 2018 to December 2020, involving patients diagnosed with GC and elevated AFP serum levels.

A Multifunctional Nanodelivery System Modified by Fusion Peptides Acts as Teriparatide Carrier for Noise-Induced Hearing Loss Therapy.

Noise-induced hearing loss (NIHL) is among the most poorly treated diseases due to irreversible damage to hair cells. Reactive oxygen species contribute to NIHL pathogenesis by injuring the inner ear hair cells. Teriparatide (PTH1-34) exerts antioxidant properties in the context of osteoporosis.

An optimized lightweight real-time detection network model for IoT embedded devices.

With the rapid development of Internet of Things (IoT) technology, embedded devices in various computer vision scenarios can realize real-time target detection and recognition tasks, such as intelligent manufacturing, automatic driving, smart home, and so on. YOLOv8, as an advanced deep learning model in the field of target detection, has attracted much attention for its excellent detection speed, high precision, and multi-task processing capability. However, since IoT embedded devices typically own limited computing resources, direct deployment of YOLOv8 is a big challenge, especially for real-time detection tasks.

Genome-wide identification of the bZIP family in Eutrema salsugineum and functional analysis of EsbZIP51 in regulating salt tolerance.

The halophyte Eutrema salsugineum is naturally distributed in saline-alkali soil and has been proposed as a model plant for understanding plant salt tolerance. As one of the largest and most diverse TF families, basic leucine zipper motif (bZIP) TFs perform robust functions in plant growth and environmental response, however the generalized information of EsbZIP genes and its regulatory role in salt tolerance has not been systematically studied to date. Here, we identified and characterized the bZIP members in E.

A Resource-Efficient Multi-Entropy Fusion Method and Its Application for EEG-Based Emotion Recognition.

Emotion recognition is an advanced technology for understanding human behavior and psychological states, with extensive applications for mental health monitoring, human-computer interaction, and affective computing. Based on electroencephalography (EEG), the biomedical signals naturally generated by the brain, this work proposes a resource-efficient multi-entropy fusion method for classifying emotional states. First, Discrete Wavelet Transform (DWT) is applied to extract five brain rhythms, i.

Long-chain chlorinated paraffins (LCCPs) exposure causes senescence and inflammatory damage in cardiomyocytes.

Humans can be exposed to LCCPs through air and diet, leading to their accumulation in the body. Given the significance of understanding potential health risks, a thorough investigation into the detrimental health impacts of LCCPs is paramount. In this study, we conducted a series of experiments to investigate the effects of LCCPs on cardiomyocytes, employing techniques such as flow cytometry, western-blot, indirect immunofluorescence, and confocal microscopy.

Impact of Acute Myocardial Injury on Short- and Long-Term Outcomes in Patients With Primary Intracerebral Hemorrhage.

Background: Myocardial injury is common after brain injury; however, few studies have reported serial cardiac troponin (cTn) measurements to distinguish whether the myocardial injury is acute or chronic. The fourth Universal Definition of Myocardial Infarction introduced for the first time the criteria for acute myocardial injury (AMI). We aimed to investigate the prevalence and prognostic implications of AMI in primary intracerebral hemorrhage.

Prognostic value of nighttime blood pressure in patients with chronic kidney disease.

The optimal blood pressure (BP) in patients with chronic kidney disease (CKD) remains uncertain. Therefore, this cohort study aimed to investigate the prognostic value of ambulatory blood pressure (ABP) in patients with CKD and to determine the optimal range for ABP. In total, 1051 hospitalized patients with CKD were enrolled.

Electrochemiluminescence Resonance Energy Transfer Biosensor for the Human-Associated Clade of Based on Prereduction-Enhanced Yttrium MOFs.

, a significant zoonotic pathogen, annually caused substantial economic losses in the swine industry and had intensified threat to public health due to the recent emergence of human-associated clade. In this study, we discovered that the rare-earth metal-based metal-organic frameworks (Y-BTC) possessed excellent ECL capabilities. After prereduction at high voltage, its ECL intensity was enhanced by two times.

Controlling shareholders' equity pledge and corporate innovation investment-empirical analysis based on pharmaceutical manufacturing.

Enterprise innovation investment is influenced by the actions of innovation subjects, whereas regulating shareholders' equity pledge behavior facilitates innovation investment and finance but also carries dangers and affects enterprise innovation investment. Methods:This paper builds an unbalanced panel model to empirically analyze the impact of controlling shareholders' equity pledges on corporate innovation and its heterogeneous characteristics. It also looks at the moderating role of corporate financing constraints and the mediating role of equity incentives, using data from A-share listed companies in China's pharmaceutical manufacturing industry from 2015 to 2022.

Numerical Investigation of Proton Exchange Membrane Fuel Cells with Symmetrical Serpentine Channels Equipped with Baffles.

The design of the flow field structure for bipolar plates significantly influences the output performance of proton exchange membrane fuel cells (PEMFCs). Adding baffles in the flow channels can enhance the transportation of reactants and electrochemical performance of the PEMFCs. In this study, three types of baffles with different shapes and sizes were designed.

Real-time shrimp freshness detection by anthocyanin-enriched wheat gluten/gelatin electrospun nanofiber films.

Electrospun nanofiber films exhibited significant potential as food freshness indicators (FFI) due to their structural advantages. Herein, a novel electrospinning film based on wheat gluten (WG), gelatin, and anthocyanins was fabricated to detect the freshness of shrimp. Compared with pure WG, an adjusted ratio of the WG to gelatin (W16E9, 16:9) improved physicochemical properties, reducing viscosity from 3.

Exploring exercise interventions in substance abuse treatment: A comprehensive bibliometric analysis.

This study aims to comprehensively evaluate the research landscape related to exercise and substance abuse over the past 2 decades. A systemic bibliometric analysis was conducted using 2 powerful tools, the Bibliometrix package for R and VOSviewer software. The analysis covered a corpus of literature indexed in the Web of Science's core collection.

Limits to timescale dependence in erosion rates: Quantifying glacial and fluvial erosion across timescales.

Earth's topography and climate result from the competition between uplift and erosion, but it has been debated whether rivers or glaciers are more effective erosional agents. We present a global compilation of fluvial and glacial erosion rates alongside simple numerical experiments, which show that the "Sadler effect," wherein geological rates show an inverse relationship with measurement timescale, comprises three distinct effects: a measurement thickness bias, a bias of erosion and redeposition, and a bias introduced by not observing quiescent intervals. Furthermore, we find that, globally, average glacial erosion rates exceed fluvial erosion rates through time by an order of magnitude, and that this difference cannot be explained by Sadlerian biases or by variations in hillslope, precipitation, or latitude.

Mediodorsal thalamus nucleus-medial prefrontal cortex circuitry regulates cost-benefit decision-making selections.

Value-based decision-making involves weighing costs and benefits. The activity of the medial prefrontal cortex reflects cost-benefit assessments, and the mediodorsal thalamus, reciprocally connected with the medial prefrontal cortex, has increasingly been recognized as an active partner in decision-making. However, the specific role of the interaction between the mediodorsal thalamus and the medial prefrontal cortex in regulating the neuronal activity underlying how costs and benefits influence decision-making remains largely unexplored.

Stable sequential dynamics in prefrontal cortex represents subjective estimation of time.

Time estimation is an essential prerequisite underlying various cognitive functions. Previous studies identified 'sequential firing' and 'activity ramps' as the primary neuron activity patterns in the medial frontal cortex (mPFC) that could convey information regarding time. However, the relationship between these patterns and the timing behavior has not been fully understood.

Inhibitory effect of Zhujing Pill on myopia progression: Mechanistic insights based on metabonomics and network pharmacology.

Objectives: This study endeavored to uncover the mechanisms by which Zhujing pill (ZJP) slows myopia progression.

Methods: We employed biometric analyses to track diopter and axial length changes in guinea pigs with negative lens-induced myopia (LIM). Through integrating metabonomics and network pharmacology, we aimed to predict the anti-myopic targets and active ingredients of ZJP.

The Effects of Dexamethasone on Human Lens Epithelial Cells and the Analysis of Related Pathways with Transcriptome Sequencing.

Background: The goal of this study was to investigate the effects of dexamethasone on human lens epithelial cells (HLECs) and the potential mechanisms.

Methods: HLECs (HLE-B3) were cultured to assess the effects of dexamethasone on cell size at different concentrations. Immunofluorescence staining was used to detect specific protein expression in HLE-B3 cells.