PLGA micro/nanoparticle vaccination elicits non-tumor antigen specific resident memory CD8 T cell protection from hepatocellular carcinoma.

Together, tumor and virus-specific tissue-resident CD8 memory T cells (TRMs) of hepatocellular carcinoma (HCC) patients with Hepatitis B virus (HBV) infection can provide rapid frontline immune surveillance. The quantity and activity of CD8 TRMs were correlated with the relapse-free survival of patients with improved health. However, HBV-specific CD8 TRMs have a more exhausted phenotype and respond more actively under anti-PDL1 or PD1 treatment of HBVHCC patients.

RPA-CRISPR/Cas12a-LFA combined with a digital visualization instrument to detect in stray dogs and cats in Zhejiang province, China.

Unlabelled: , which causes toxoplasmosis, is prevalent in warm-blooded animals, such as cats, dogs, and humans. causes economic losses to livestock production and represents a potential risk to public health. Dogs and cats are common hosts in the epidemiology of toxoplasmosis.

Application of gold immunochromatographic assay strip combined with digital evaluation for early detection of Toxoplasma gondii infection in multiple species.

Background: Timely diagnosis of Toxoplasma gondii infection is necessary to prevent and control toxoplasmosis transmission. The gold immunochromatographic assay (GICA) is a means of rapidly detecting pathogen in samples. GICA-based diagnostic methods have been developed to accurately detect pathogens with high sensitivity and specificity, and their application in T.

Stimulating Phonon Bottleneck Effect in Organic Semiconductors by Charge-Transfer-Mediated J-Aggregation.

Hot carriers rapidly lose kinetic energies on a subpicosecond time scale, posing significant limitations on semiconductors' photon-conversion efficiencies. To slow the hot carrier cooling, the phonon bottleneck effect is constructed prevalently in quantum-confined structures with discrete energy levels. However, the maximum energy separation (Δ) between the energy levels is in a range of several hundred meV, leading to unsatisfactory cooling time.

Simultaneous Hydrogen Generation and Exciplex Stimulated Emission in Photobasic Carbon Dots.

Photocatalytic water splitting is a promising approach to generating sustainable hydrogen. However, the transport of photoelectrons to the catalyst sites, usually within ps-to-ns timescales, is much faster than proton delivery (∼μs), which limits the activity. Therefore, the acceleration of abstraction of protons from water molecules towards the catalytic sites to keep up with the electron transfer rate can significantly promote hydrogen production.

Production of MSTN knockout porcine cells using adenine base-editing-mediated exon skipping.

Gene-knockout pigs have important applications in agriculture and medicine. Compared with CRISPR/Cas9 and cytosine base editing (CBE) technologies, adenine base editing (ABE) shows better safety and accuracy in gene modification. However, because of the characteristics of gene sequences, the ABE system cannot be widely used in gene knockout.

Deep-blue thermally activated delayed fluorescence carbon dots with ultralong lifetime.

Carbon dots (CDs) with deep-blue thermally activated delayed fluorescence (TADF) of more than 2 s were developed, exhibiting the longest lifetime to date. In contrast to the established deep-blue TADF systems, this developed CD-based system (BNCDs) could be facilely and effectively synthesized, and more impressively, the emission lasted for more than 16 s (to the naked eye). XRD, TEM, FT-IR, and XPS analyses were conducted, and structural characterizations indicated that the CDs formed hydrogen bonding with BO.

Metal-Molecule-Metal Junctions on Self-Assembled Monolayers Made with Selective Electroless Deposition.

Electronic transport through molecular-scale devices has been studied extensively for its extraordinary dimension superiority. Assembling such devices into large-scale functional circuits is crucial since the molecular tunnel junctions must be reliable, stable and reproducible during technological applications. In ideal circumstances, the device architecture should be designed such that the metal-molecule-metal (MMM) junctions can be analyzed by the more sensitive four point probe system.

Photobase effect for just-in-time delivery in photocatalytic hydrogen generation.

Carbon dots (CDs) are a promising nanomaterial for photocatalytic applications. However, the mechanism of the photocatalytic processes remains the subject of a debate due to the complex internal structure of the CDs, comprising crystalline and molecular units embedded in an amorphous matrix, rendering the analysis of the charge and energy transfer pathways between the constituent parts very challenging. Here we propose that the photobasic effect, that is the abstraction of a proton from water upon excitation by light, facilitates the photoexcited electron transfer to the proton.

Hydrothermally Induced Oxygen Doping of Graphitic Carbon Nitride with a Highly Ordered Architecture and Enhanced Photocatalytic Activity.

As an amorphous or semicrystalline material, graphitic carbon nitride (g-C N ) displays poor photocatalytic activity owing to rapid recombination of the photogenerated charge carriers, which is mainly caused by a high density of defects in the graphitic structure. In this work, a porous O-doped g-C N (P-CNO) nanosheet with a highly ordered architecture is fabricated by introducing a novel hydrothermal treatment to the precursor before the final thermal condensation. The photocatalytic hydrogen evolution rate (HER) and HER per surface area of P-CNO are 13.

Pt-decorated zinc oxide nanorod arrays with graphitic carbon nitride nanosheets for highly efficient dual-functional gas sensing.

In this work, well-aligned ZnO nanorods were grown on the substrate of exfoliated g-CN nanosheets via a microwave-assisted hydrothermal synthesis, and then Pt/ZnO/g-CN nanostructures were obtained after the deposition of Pt nanoparticles. The growth of vertically ordered ZnO nanorods was occurred on g-CN nanosheets through the bonding interaction between Zn and N atoms, which was confirmed by XPS, FT-IR data and molecular orbital theory. The Pt/ZnO/g-CN nanostructures sensor exhibited the remarkable sensitivity, selectivity, and fast response/recovery time for air pollutants of ethanol and NO.

Efficient generation and tight focusing of radially polarized beam from linearly polarized beam with all-dielectric metasurface.

We propose a single layer all-dielectric metasurface lens to simultaneously convert and focus an incident linear polarization into a radial beam with high efficiency and high numerical aperture (NA). It shows a better focusing property compared with the linearly polarized metasurface lens for high NA. A tight spot size (0.