There are two phenotypes in the natural populations of , which is an ideal model for studying the formation of markings and body color in crustaceans. In a previous study, we used comparative transcriptome technology to screen some functional genes related to body color regulation. Here, high-throughput sequencing technology was used to perform microRNA (miRNA) sequencing analysis on the exoskeleton of with two types of carapace markings, and functional studies of related genes were performed.
View Article and Find Full Text PDFThe electrocatalytic nitrate reduction to hydroxylamine (NHOH) is a challenging catalytic process that has gained significant attention. However, its performance is hindered by the low selectivity of the electrocatalysts. Here, intermetallic PtSn nanosheets with p-d orbital hybridization have been synthesized, which significantly enhances the performance of electrocatalytic nitrate reduction to NHOH.
View Article and Find Full Text PDFParkinson's disease (PD) is the second most common neurodegenerative disease but has limited medications. Targeting leucine-rich repeat kinase 2 (LRRK2) has been identified as a potential strategy for the treatment of PD. The development of LRRK2 inhibitors has attracted much interest, and various compounds have been reported with significant improvement in preclinical and clinical models.
View Article and Find Full Text PDFJ Nanobiotechnology
March 2025
The accurate assessment of platelet activity is crucial in clinical practice and scientific research owing to the pivotal role of platelets in the progression of cardiovascular conditions, such as arterial thrombotic diseases. However, conventional platelet activity assessment methods are currently limited by their requirement of substantial blood samples and inadequate high-throughput capabilities, and therapeutic resistance induced by antiplatelet agents impedes treatment efficacy. In this study, we developed a microdroplet-based platelet function detection method, referred to as NebulaPlate, to achieve miniaturized and robust platelet activity assessment, thereby overcoming current challenges.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
February 2025
Albumin-based drug delivery system, exemplified by FDA-approved treatments like Abraxane, have demonstrated significant potential in cancer therapy. However, albumin carriers still suffer from poor tumor-targeting capability, leading to low efficacy and systemic side effects on healthy cells in applications. Here, we report a general method for modification of albumin drugs by aptamer coating shell that are hydrophobically inserted into the albumin surface, for constructing albumin drugs-cored spherical nucleic acid (adSNA).
View Article and Find Full Text PDFInt J Biol Macromol
February 2025
Understanding the impact of mildew on lignin and hemicelluloses within plant cell walls is crucial for addressing biomass degradation and antimicrobial studies. In this work, Two-dimensional nuclear magnetic resonance (2D NMR) and nanoindentation techniques were used to characterize the effects of three mildew species-Aspergillus niger (AN), Trichoderma viride (TV), and Penicillium citrinum (PC)-on lignin and hemicelluloses within bamboo cell walls. 2D NMR detected bond changes, while nanoindentation measured mechanical decline.
View Article and Find Full Text PDFThe acetone present in exhaled breath is a promising indicator for diagnosing human health. The fluorescent hydrogel sensor-based portable sensing platform is a highly effective tool for the on-site detection of acetone. However, existing hydrogel sensors are often limited by their irreversibility and autofluorescence.
View Article and Find Full Text PDFArsenic contamination in the environment poses a global health challenge, affecting populations in over seventy countries. Electron shuttles (ESs) and iron-bearing clay minerals commonly coexist in high-arsenic environments. Clay minerals are critical hosts in controlling arsenic mobilization.
View Article and Find Full Text PDFResearch on metal-organic framework (MOF) aerogels is relatively scarce, primarily constrained by the limited availability of synthetic methods. Herein, a water-induced rapid conversion process of MOF powder to MOF aerogel is demonstrated, where the macroscopic transition is essentially due to the reassembly of microscopic constituent units and the rapid alteration of morphological structure. The derived catalyst possesses abundant holes left by the acid leaching process, leading to the high enrichment of O-coordinated single-atom Ni sites on the concomitant carbon edges.
View Article and Find Full Text PDFCreatinine is an essential biomarker for the clinical diagnosis and treatment of renal insufficiency. Although fluorescent methods are powerful tools for creatinine detection, almost all reported fluorescent probes rely on short-wavelength excitation and a single fluorescent signal, making them susceptible to environmental and operational conditions. In this study, a near-infrared excited, highly sensitive, and multi-output signal sensing system was established using upconversion nanoparticles and 3,5-dinitrobenzoic acid (DNBA) for synergistic luminescent and colorimetric assay for strong visual detection of creatinine.
View Article and Find Full Text PDFParkinson's disease (PD) is a common neurodegenerative disease affecting nearly 10 million people worldwide and placing a heavy medical burden on both society and families. However, due to the complexity of its pathological mechanisms, current treatments for PD can only alleviate patients' symptoms. Therefore, novel therapeutic strategies are urgently sought in clinical practice.
View Article and Find Full Text PDFAsia Pac J Clin Oncol
December 2024
Aims: Adrenocortical carcinoma is a rare cancer known for its high recurrence rate. This study aimed to evaluate the effects of postoperative adjuvant radiotherapy on the outcomes of patients with adrenocortical carcinoma.
Methods: We examined patients with adrenocortical carcinoma who had undergone curative tumor resection.
Currently, hydrogen evolution reaction (HER) in alkaline seawater still faces problems such as low catalyst activity and Cl poisoning of active sites. In this work, an electron transfer facilitator of oxygen vacancies is introduced as a driving force for electronic transmission, which enhances the electron-metal-support interactions (EMSI) effect while introducing a charge protective layer, realizing killing two birds with one stone. In situ characterizations and density functional theory (DFT) calculations demonstrate that the EMSI effect enhances the H transfer step at the interface.
View Article and Find Full Text PDFBackground And Objectives: To investigate the risk factors of renal function deterioration after radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC).
Methods: A total of 153 patients with UTUC who underwent radical surgery at a high-volume center in China from January 2015 to December 2019 were included in this study. The renal function of all patients was evaluated during follow-up.
Cuproptosis, a recently identified form of copper-dependent cell death, shows promising tumor suppressive effects with minimal drug resistance. However, its therapeutic efficacy is hampered by its dependence on copper ions and the glutathione (GSH)-rich microenvironment in tumors. Here, we have developed polyvalent aptamer nanodrug conjugates (termed CuPEs@PApt) with a nucleosome-like structure to improve tumor cuproptosis therapy by exploiting mitochondrial copper overload and GSH depletion.
View Article and Find Full Text PDFUnlabelled: Sliced bamboo veneer used as a high-end decoration material is a highly innovative material for the deep processing of bamboo. However, bamboo is rich in starch and small molecular soluble sugars, making it susceptible to mildew infection and limiting the wide application of sliced veneer plybamboo. Spice essential oils are considered green and safe antimildew agents, which are cheap and accessible.
View Article and Find Full Text PDFObjective: To investigate the effects of earplug type and noise exposure level on textile workers' personal attenuation rating (PAR).
Design: Initial and follow-up visits were conducted at a 17-month interval. At each visit, a baseline HPD fit test was performed using either a 3M foam or pre-molded earplug, as chosen by the workers.
The development of oxygen evolution reaction (OER) electrocatalyst for seawater electrolysis plays a crucial role in producing renewable hydrogen energy. However, during the seawater electrolysis process, the anode inevitably undergoes chloride oxidation reaction (ClOR) due to Cl adsorption, making the seawater electrolysis process difficult to sustain. Inspired by the selective permeability of cell membranes, we propose a biomimetic design of frustrated Lewis pairs (FLPs) layers for selective seawater oxidation.
View Article and Find Full Text PDFPhotopharmacology is an emerging method in medicinal chemistry to achieve light-controlled drug activity. Azobenzene-based photoswitchable ligands have found widespread application as chemical tools in photopharmacological studies. This study pioneers the design and synthesis of a novel series of photoswitchabled butyrylcholinesterase (BChE) inhibitors, achieved by strategically integrating an azo moiety into an N-benzyl benzamide scaffold.
View Article and Find Full Text PDFPlums ( and ) are prevalent in southwestern China, and have attracted interest owing to their delectable taste and exceptional nutritional properties. Therefore, this study aimed to investigate the nutritional and flavor properties of plum to improve its nutritional utilization. Specifically, we determined the soluble sugars, organic acids, and phenolic components in 86 accessions using high-performance liquid chromatography.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
December 2024
Topological defects are inevitable existence in carbon-based frameworks, but their intrinsic electrocatalytic activity and mechanism remain under-explored. Herein, the hydrogen evolution reaction (HER) of pentagonal carbon-rings is probed by constructing pentagonal ring-rich carbon (PRC), with optimized electronic structures and higher HER activity relative to common hexagonal carbon (HC). Furthermore, to improve the reactivity, we couple Ru clusters with PRC (Ru@PRC) through p-d orbital hybridization between C and Ru atoms, which drives a shortcut transfer of electrons from Ru clusters to pentagonal rings.
View Article and Find Full Text PDFIntroduction: The systemic inflammatory response syndrome during the perioperative period of cardiac surgery can lead to serious postoperative complications and significantly increase the hospital mortality rate. Colchicine, a widely used traditional anti-inflammatory drug, has good clinical value in cardiovascular anti-inflammatory therapy. Our preliminary single-centre study had confirmed the protective value of colchicine in patients undergoing cardiac surgery with cardiopulmonary bypass.
View Article and Find Full Text PDFBioorthogonal chemistry has provided an elaborate arsenal to manipulate native biological processes in living systems. As the great advancement of nanotechnology in recent years, bioorthogonal nanozymes are innovated to tackle the challenges that emerged in practical biomedical applications. Bioorthogonal nanozymes are uniquely positioned owing to their advantages of high customizability and tunability, as well as good adaptability to biological systems, which bring exciting opportunities for biomedical applications.
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