Gut microbiota-derived tryptophan metabolites regulated by Wuji Wan to attenuate colitis through AhR signaling activation.

Disruption of the intestinal mucosal barrier caused by gut dysbiosis and metabolic imbalance is the underlying pathology of inflammatory bowel disease (IBD). Traditional Chinese medicine Wuji Wan (WJW) is commonly used to treat digestive system disorders and showed therapeutic potential for IBD. In this interdisciplinary study, we aim to investigate the pharmacological effects of WJW against experimental colitis by combining functional metabolomics and gut-microbiota sequencing techniques.

Multi-Modal Data-Efficient 3D Scene Understanding for Autonomous Driving.

Efficient data utilization is crucial for advancing 3D scene understanding in autonomous driving, where reliance on heavily human-annotated LiDAR point clouds challenges fully supervised methods. Addressing this, our study extends into semi-supervised learning for LiDAR semantic segmentation, leveraging the intrinsic spatial priors of driving scenes and multi-sensor complements to augment the efficacy of unlabeled datasets. We introduce LaserMix++, an evolved framework that integrates laser beam manipulations from disparate LiDAR scans and incorporates LiDAR-camera correspondences to further assist data-efficient learning.

Benchmarking and Improving Bird's Eye View Perception Robustness in Autonomous Driving.

Recent advancements in bird's eye view (BEV) representations have shown remarkable promise for in-vehicle 3D perception. However, while these methods have achieved impressive results on standard benchmarks, their robustness in varied conditions remains insufficiently assessed. In this study, we present RoboBEV, an extensive benchmark suite designed to evaluate the resilience of BEV algorithms.

Experimental Study of Airworthiness Compliance Verification of High-Temperature Environment in Aircraft Cockpit.

Unlabelled: The aim of this study was to assess the applicability of the Mechanical Systems Coordination Working Group's (MSCWG) findings, based on FAR 25.831(g), to Chinese pilots through a human physiological experiment conducted in a high-temperature environment to investigate the effects of core temperature.

Methods: A controlled experiment was carried out in a high-temperature environment simulation room involving a cohort of healthy males aged 18-50 years.

Regulatory significance of terminator: A systematic approach for dissecting terminator-mediated enhancement of upstream mRNA stability.

The primary function of terminators is to terminate transcription in gene expression. Although some studies have suggested that terminators also contribute positively to upstream gene expression, the extent and underlying mechanism of this effect remain largely unexplored. Here, the correlation between terminating strength and upstream mRNA stability was investigated by constructing a terminator mutation library through randomizing 5 nucleotides, assisted by FlowSeq technology, terminator variants were categorized based on the downstream fluorescence intensity, followed by high-throughput sequencing.

Multi-stimuli actuation of a photoresponsive azobenzene based molecular switch.

There has been considerable interest in building switching functions into self-assembled monolayers with switching actuated by external stimuli such as light, electrical current, heat, pressure or chemical changes. In this study, dual switching functionality has been built into azobenzene based molecular monolayers. Switching behaviour has been compared for unsubstituted azobenzene monolayer adsorbates and two other monolayers whose position on the terminal phenyl group is substituted by ethyl and isopropyl chains, respectively.

Scalable Hierarchically Structured Materials from a Multiscale Particle System Enabled by Microscaffolds.

Structural hierarchy is the key to manufacturing multiscale particle-based composite materials. A novel manufacturing method was developed to generate scalable hierarchical structures in concrete. The new method used 3D-printed microscaffolds to interact with the multiscale particle packing in concrete, resulting in a structured lightweight composite material.

Promoting positive youth development in rural communities: Integrating social work, psychology, and education.

Considering the peculiar socio-cultural background and developmental obstacles encountered by rural youth in China, the study examines the necessity of adopting an integrated strategy that brings together social work, psychology, and education to promote positive youth development. This research intends to fill the gap by explaining the impact of these factors on community engagement and youth development in China. Targeted programs were also suggested according to the needs of rural youth in China.

Hydrodynamic solar-driven interfacial evaporation - Gone with the flow.

Evaporation has been one of the most classic desalination processes on the Earth. When we try to use the power of water flow itself, the evaporation process can perform even better. Here, we report a hydrodynamic solar-driven interfacial evaporation process which water evaporation rate can achieve 6.

The Burden and Clinical Features of Neovascular Glaucoma in a Major Tertiary Care Center in China.

Prcis: This research presents the burden and clinical characteristics of NVG in Zhongshan Ophthalmic Center, employing the most extensive sample size and the longest uninterrupted temporal duration so far, which may provide a theoretical reference for the effective prevention and diagnosis of NVG.

Purpose: To summarize the burden and clinical characteristics of neovascular glaucoma (NVG) in a major tertiary care center in China.

Methods: The clinical data of NVG patients in Zhongshan Ophthalmic Center (ZOC) between 2012 and 2021 were collected retrospectively, including their age, sex, the affected eye, best-corrected visual acuity (BCVA), intraocular pressure (IOP), clinical stage and etiology.

Reliable assessment and prediction of moderate preoxidation of sodium hypochlorite for algae-laden water treatment.

Chemical moderate preoxidation for algae-laden water is an economical and prospective strategy for controlling algae and exogenous pollutants, whereas it is constrained by a lack of effective on-line evaluation and quick-response feedback method. Herein, excitation-emission matrix parallel factor analysis (EEM-PARAFAC) was used to identify cyanobacteria fluorophores after preoxidation of sodium hypochlorite (NaClO) at Excitation/Emission wavelength of 260(360)/450 nm, based on which the algal cell integrity and intracellular organic matter (IOM) release were quantitatively assessed. Machine learning modeling of fluorescence spectral data for prediction of moderate preoxidation using NaClO was established.

Stress Suppression Design for Radiofrequency Microelectromechanical System Switch Based on a Flexible Substrate.

A novel stress suppression design for flexible RF MEMS switches has been presented and demonstrated through theoretical and experimental research to isolate the stress caused by substrate bending. An RF MEMS switch with an S-shaped microspring structure was fabricated by the two-step etching process as a developmental step toward miniaturization and high reliability. The RF MEMS switches with an S-shaped microspring exhibited superior microwave performance and stable driving voltage under different substrate curvatures compared to the conventional non-microspring switches, demonstrating that the bending stress is successfully suppressed by the S-shaped microspring and the island structure.

Playing for 3D Human Recovery.

Image- and video-based 3D human recovery (i.e., pose and shape estimation) have achieved substantial progress.

Adversarial multi-task underwater acoustic target recognition: Toward robustness against various influential factors.

Underwater acoustic target recognition based on passive sonar faces numerous challenges in practical maritime applications. One of the main challenges lies in the susceptibility of signal characteristics to diverse environmental conditions and data acquisition configurations, which can lead to instability in recognition systems. While significant efforts have been dedicated to addressing these influential factors in other domains of underwater acoustics, they are often neglected in the field of underwater acoustic target recognition.

Advancing robust underwater acoustic target recognition through multitask learning and multi-gate mixture of experts.

Underwater acoustic target recognition has emerged as a prominent research area within the field of underwater acoustics. However, the current availability of authentic underwater acoustic signal recordings remains limited, which hinders data-driven acoustic recognition models from learning robust patterns of targets from a limited set of intricate underwater signals, thereby compromising their stability in practical applications. To overcome these limitations, this study proposes a recognition framework called M3 (multitask, multi-gate, multi-expert) to enhance the model's ability to capture robust patterns by making it aware of the inherent properties of targets.

Equivalent analysis model of a GaN LED used as a receiver.

In general, visible light communication (VLC) uses LEDs as transmitters. However, LEDs can serve as receivers to construct a simple duplex VLC system that uses only two LEDs instead of one LED and one photo-diode (PD). There is a lack of effective equivalent analysis models for characterizing and evaluating the inherent behavioral characteristics of LEDs used as receivers.

Recent Advances in High-Rate Solar-Driven Interfacial Evaporation.

Recent advances in solar-driven interfacial evaporation (SDIE) have led to high evaporation rates that open promising avenues for practical utilization in freshwater production and industrial application for pollutant and nutrient concentration, and resource recovery. Breakthroughs in overcoming the theoretical limitation of 2D interfacial evaporation have allowed for developing systems with high evaporation rates. This study presents a comprehensive review of various evaporator designs that have achieved pure evaporation rates beyond 4 kg m h, including structural and material designs allowing for rapid evaporation, passive 3D designs, and systems coupled with alternative energy sources of wind and joule heating.

Impacts of sulfamethoxazole stress on vegetable growth and rhizosphere bacteria and the corresponding mitigation mechanism.

Antibiotics are an important pharmaceutical class excessively used by humans. Its presence in the soil can impact plant growth and induce antibiotic resistance. This research studies the effect of sulfamethoxazole (SMX) on plant growth, rhizosphere bacteria composition, and resistance genes.

Percutaneous endoscopic lumbar discectomy for single and double segment lumbar disc herniation with sciatic scoliosis in adults: a retrospective study.

Objective: Sciatic scoliosis can be seen in patients with lumbar disc herniation. Percutaneous endoscopic lumbar discectomy (PELD) is a common surgical method for the treatment of lumbar disc herniation. The difference between single-segment lumbar disc herniation and double-segment lumbar disc herniation with Sciatic Scoliosis in adults after PELD needs further study.

Physiologically-based pharmacokinetic modeling for optimal dosage prediction of olaparib when co-administered with CYP3A4 modulators and in patients with hepatic/renal impairment.

This study aimed to develop a physiologically-based pharmacokinetic (PBPK) model to predict the maximum plasma concentration (C) and trough concentration (C) at steady-state of olaparib (OLA) in Caucasian, Japanese and Chinese. Furthermore, the PBPK model was combined with mean and 95% confidence interval to predict optimal dosing regimens of OLA when co-administered with CYP3A4 modulators and administered to patients with hepatic/renal impairment. The dosing regimens were determined based on safety and efficacy PK threshold C (< 12,500 ng/mL) and C (772-2500 ng/mL).

Fate of sulfamerazine by synchronous adsorption and photocatalysis dependent on natural organic matter properties.

Natural organic matter (NOM) can impede the removal of organic micro-pollutants (OMPs) through several mechanisms, including inner filter effect, competition with the target OMP, and radical scavenging, during synchronous adsorption/photocatalysis of multi-functional composites. In this study, the fate and inhibitory mechanisms of sulfamerazine (SMZ, a model OMP) that occurred in presence of seven different NOM samples (i.e.

Effect of different titration methods on right heart function and prognosis in patients with acute respiratory distress syndrome.

Background: Acute respiratory distress syndrome (ARDS) is a common disease in intensive critical care(ICU), and the use of positive end-expiratory pressure(PEEP) during mechanical ventilation can increase the right heart afterload and eventually cause right heart dysfunction. For these factors causing acute cor pulmonale(ACP), especially inappropriate mechanical ventilation settings, it is important to explore the effect of PEEP on right heart function.

Objective: To investigate the effects of three titration methods on right heart function and prognosis in patients with ARDS.

Water and heat exchange responses to flooding and local storm events in the hyporheic zone driven by a meandering bend.

The hyporheic zone, i.e. the groundwater-surface water interface within riverine/riparian ecosystems, plays a key role in water transport, energy flow and biogeochemical cycling at watershed scales.

Noncontact Conjunctiva: A Better Mitomycin C Application Site for Trabeculectomy.

Introduction: Bleb scarring is the most important complication of trabeculectomy. Changing the application position of mitomycin C (MMC) during trabeculectomy might affect the surgery outcome. Our aim is to compare the effectiveness and safety of intraocular pressure (IOP) lowering in two different application sites of mitomycin in trabeculectomy.