Publications by authors named "Jiatong Xu"
Article Synopsis
- - The study reviewed ultrasound characteristics of alveolar soft part sarcoma (ASPS) in 20 pediatric cases diagnosed from January 2014 to January 2024.
- - Tumors were found equally in the trunk/limbs and head/neck, with head and neck tumors being smaller and more symptomatic, yet showing less metastasis.
- - Key ultrasound features included hypoechoic masses with clear borders, varied echogenicity, and pronounced vascularity, highlighting a correlation between tumor size and metastasis risk.
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by binding to the 3'-untranslated regions of target mRNAs, influencing various biological processes at the post-transcriptional level. Identifying miRNA transcription start sites (TSSs) and transcription factors' (TFs) regulatory roles is crucial for elucidating miRNA function and transcriptional regulation. miRStart 2.
View Article and Find Full Text PDFIron death is a novel type of programmed cell death caused by excessive accumulation of iron-dependent lipid peroxidation products; however, the function of iron death during porcine oocyte maturation and embryo growth is poorly understood. This study was conducted to investigate the mechanism of ferric ammonium citrate (FAC) in regulating iron death in mature oocytes in vitro through the NRF2 signaling pathway, and subsequent embryonic development. The experiment was divided into four groups: 0 (control group), 2, 5, and 10 μM FAC.
View Article and Find Full Text PDFObjectives: This study aimed to investigate the association between contrast-enhanced ultrasound-detected (CEUS) perfusion patterns of carotid plaque and the occurrence of stroke.
Materials And Methods: This prospective observational study finally enrolled 256 patients (151 of them having undergone CEUS) from 7851 patients who underwent carotid artery ultrasound from May 2019 to December 2019 with the endpoint being the occurrence of stroke. The risk factors and carotid ultrasound fetures was obtained from those patients.
Article Synopsis
- Previous studies suggest that gay and bisexual men show homogamy in their partner preferences, particularly related to physique.
- The research analyzed 188,716 profiles from Blued, a popular gay dating app in China, using multiple group latent class analysis to identify physique preference patterns across different body types.
- Findings revealed seven classes of physique preferences, highlighting that body type significantly influences attraction, with specific preferences emerging based on one's own physique and sexual self-labeling (top, bottom, versatile).
Article Synopsis
- Understanding the sol-gel transition of different glucans reveals how their unique molecular structures influence their gelation behaviors, which is important for various applications.
- The study used computational simulations and advanced spectroscopy methods to analyze the differences in gelation between methylated (1,3)-β-d-glucan (MECD) and methylated (1,4)-β-d-glucan (MC), despite them having similar degrees of substitution.
- The findings show that MECD forms a compact, irregular helical gel while MC undergoes a "coil-to-ring" transition, highlighting that variations in hydrophobic interactions and hydrogen bonding significantly affect their gelation patterns.
Article Synopsis
- Time-series experiments help us understand biological processes over time, but identifying causal mechanisms can be challenging.
- This study introduces a new algorithm that combines known biological networks with gene expression data to map out signaling pathways during the transition from aerobic to anaerobic conditions.
- The research identifies a novel regulatory network involving environmentally responsive genes that influence nitrogen metabolism regulators, ultimately affecting cell motility, enhancing our understanding of microbial physiology and its potential biotechnological applications.
Introduction And Importance: Congenital hepatoblastoma is an exceedingly rare neoplasm, predominantly documented as isolated instances, with contentious aspects surrounding its therapeutic approaches and prognostic implications. This study aims to comprehensively summarize and evaluate the management experience of congenital hepatoblastoma (CHB).
Case Presentation: This cohort comprised five infants diagnosed with hepatoblastoma, confirmed through pathological examination, and with an onset of symptoms before 28 days of age.
[Long-term auditory monitoring in children with Alport syndrome based on different degrees of renal injury].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
January 2024
To investigate long-term auditory changes and characteristics of Alport syndrome（AS） patients with different degrees of renal injury. Retrospectively analyzing clinical data of patients diagnosed AS from January 2007 to September 2022, including renal pathology, genetic detection and hearing examination. A long-term follow-up focusing on hearing and renal function was conducted.
View Article and Find Full Text PDFArticle Synopsis
- Schistosomiasis is a major neglected tropical disease that affects mostly economically underdeveloped tropical regions, making it a significant public health challenge.
- Effective control of the disease requires more than just medication; it involves managing the life cycle of intermediate host snails, which are crucial for the transmission of schistosomiasis.
- Research on the immune interactions between specific snail species (like B. glabrata and O. hupensis) and the schistosome parasites is key to developing environmentally friendly strategies for disease prevention and control.
Article Synopsis
- Nanocellulose is an eco-friendly nanomaterial gaining popularity for its versatile applications, yet its rheological properties, particularly yielding behavior, need further study.
- This research focused on comparing the viscoelasticity, thixotropy, and yielding behavior of two types of nanocellulose: rod-shaped cellulose nanocrystals (CNCs) and filamentous cellulose nanofibrils (CNFs).
- Findings indicated that CNF suspensions exhibit stronger thixotropic behavior and higher yield stress than CNC suspensions, linked to their higher aspect ratio and structural strength, providing valuable insights for practical uses of nanocellulose.
Background: Allergic rhinitis (AR) is a common nasal inflammatory disorder that severely affects an individual's quality of life (QoL) and poses a heavy financial burden. In addition to routine treatments, probiotic intervention has emerged as a promising strategy for preventing and alleviating allergic diseases. The main objective of this study was to determine the effect of a novel multi-strain probiotic mixture on AR symptoms and investigate potential targets underlying the probiotic intervention.
View Article and Find Full Text PDFSepsis-associated acute kidney injury (SA-AKI) is a severe and life-threatening condition with high morbidity and mortality among emergency patients, and it poses a significant risk of chronic renal failure. Clinical treatments for SA-AKI remain reactive and non-specific, lacking effective diagnostic biomarkers or treatment targets. In this study, we established an SA-AKI mouse model using lipopolysaccharide (LPS) and performed proteomics and metabolomics analyses.
View Article and Find Full Text PDFEthnopharmacological Relevance: Sophorae Flavescentis Radix (Kushen) is the primary herb component of Compound Kushen Injection (CKI), an approved clinical treatment for tumors. Despite CKI's widespread use, the underlying mechanisms of Kushen regarding microRNA-target and pathway remain unclear in non-small cell lung cancer (NSCLC).
Aim Of The Study: This study aimed to elucidate the crucial miRNAs-targets and pathways responsible for the Kushen's impact on NSCLC.
Background: Indocyanine green (ICG) fluorescence guided surgery has been used to treat childhood hepatoblastoma (HB), but the advantages and disadvantages of this technique have not been fully discussed. The purpose of this study is to summarize the experience and to explore the clinical value of this technique for children with HB.
Methods: 45 children with HB who underwent ICG fluorescence guided surgery (n = 22) and general surgery (n = 23) in our center from January 2020 to December 2022 were enrolled retrospectively.
Article Synopsis
- - This study examines the use of Indocyanine Green (ICG) fluorescence imaging in pediatric renal cancers, highlighting its safety and feasibility during surgical procedures.
- - Researchers analyzed data from 7 pediatric cases, confirming that ICG successfully visualized tumors in 6 instances and allowed for the identification of sentinel lymph nodes in 3 patients, with no reported adverse reactions.
- - Findings suggest that while ICG imaging is beneficial for targeted surgeries, factors like dosage and renal blood flow can impact its effectiveness, indicating a need for optimized administration methods in future applications.
Article Synopsis
- The study investigates the CT and MRI characteristics of hairy polyps, predominantly described in previous case reports, to better understand their imaging features and associated conditions.
- In reviewing 14 patients, the research revealed a significant female-to-male ratio, with the majority of masses originating from the back of the soft palate and showing a common appearance of pedicled masses with fat and soft tissue.
- The findings indicate that while hairy polyps typically exhibit certain imaging traits, variations can occur, and they may be linked to other congenital issues; CT and MRI are effective diagnostic tools in these cases.
Article Synopsis
- Renal tubular epithelial cells rely heavily on mitochondrial energy supply, and ALDH2 is crucial for alcohol metabolism and ATP production; however, its role in kidney injury isn't fully understood.
- In models of acute kidney injury, ALDH2 levels were significantly reduced, and knockout mice exhibited worse kidney damage and cell death after cisplatin treatment, while activating ALDH2 showed protective effects.
- ALDH2 activation improves mitochondrial function by interacting with PGC-1α, boosting mitochondrial biogenesis, suggesting that targeting ALDH2 could be a promising therapy for preventing acute kidney injury.
Background: Chronic active Epstein‒Barr virus infection (CAEBV) is an intractable and progressive disease. T cells or NK cells infected by EBV can proliferate and infiltrate into multiple organs. CAEBV combined with gastrointestinal involvement is a rare clinical disease that has not been well described, and sometimes it may clinically mimic gastroenteritis or inflammatory bowel disease.
View Article and Find Full Text PDFBackground: Indocyanine green (ICG) navigation surgery has been used for hepatoblastoma (HB) in children but the technique has been reported for using in other childhood liver cancers were rare. This article summarizes the application experience of ICG in HB and other childhood liver cancers in children and explores the role of fluorescence intensity measurement in identifying tumors.
Methods: To summarize the clinical experience of children with liver cancer treated by ICG navigation surgery.
Background: Benign splenic lesions are rarely encountered. This study aimed to review the clinical characteristics and surgical outcomes in a case series of 30 pediatric patients.
Methods: From January 1st, 2001 to December 31st, 2021, 30 pediatric patients from a single center were consecutively included.
Background: Overweight/obesity and depression are highly co-occurring conditions with shared pathophysiology as well as social and economic determinants. To our knowledge, this is the first systematic review aims to comprehensively synthesize extant literature with a focus on the effectiveness of interventions targeting obesity and depression comorbidity.
Methods: We searched databases including MEDLINE, ProQuest Central, Web of Science, PsycINFO, Cochrane Library, from inception of the databases until Nov 12, 2021.
Article Synopsis
- - The study examines the link between cognitive behavioral therapy (CBT) and changes in peripheral interleukin-6 (IL-6) levels in individuals with depression, revealing that IL-6 levels significantly decrease after CBT treatment.
- - A systematic review included 10 studies with 940 participants, showing a small but notable effect of CBT on reducing IL-6 levels, particularly in sessions lasting 8 weeks or less and in participants diagnosed with major depressive disorder (MDD).
- - The findings suggest that CBT may have a similar influence on IL-6 as other depression treatments, highlighting an important connection in understanding antidepressant mechanisms.
Article Synopsis
- - In September 2021, a leaf spot disease affecting about 10% of blue honeysuckle 'Lanjingling' was observed in a field in Dandong City, China, with symptoms including black mildew spots and yellow halos on leaves.
- - Small leaf samples were cultured, resulting in six purified strains of the fungus, identified as Alternaria alternata based on morphological characteristics and measurements.
- - Molecular analysis confirmed the identity of the fungus through gene amplification and sequencing, leading to a greenhouse experiment that replicated the disease symptoms on healthy plants when exposed to the fungal spores.