Publications by authors named "Jiating Ni"
Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations have been identified in more than 20% of human cancers as one of the most common oncogenes, especially in non-small cell lung, colorectal, and pancreatic cancers. KRAS regulates the activation of multiple proteins involved in cell growth and proliferation, such as extracellular regulated protein kinases and mammalian target of rapamycin, as a hub between the epidermal growth factor receptor (EGFR) and downstream MAPK and AKT pathways. However, due to the lack of a binding pocket, KRAS has long been considered an undruggable target in recent decades until the discovery of Sotorasib (AMG510).
View Article and Find Full Text PDFSynthesis, Antioxidant Activity, and Molecular Docking of Novel Paeoniflorin Derivatives.
Chem Biol Drug Des
September 2024
Article Synopsis
- * The study created and tested 25 PF derivatives for their antioxidant properties using various radical scavenging experiments and a cellular model with PC12 cells.
- * Among the derivatives, compound 22 exhibited strong antioxidant effects and was non-toxic to cells, likely due to a specific chemical modification enhancing its ability to combat oxidative stress by activating Nrf2 protein expression.
Article Synopsis
- The study investigates the effectiveness of the "schisandra-evodia" herb pair in treating Alzheimer's disease (AD) in rats through pharmacodynamic assessments and metabolomic analyses.
- Results indicated that S-E significantly improved long-term memory, spatial learning, and reduced cognitive impairment associated with Aβ in AD rats, while also enhancing neuron structure and reducing inflammation.
- Metabolomic analysis of serum and urine revealed changes in 40 serum and 38 urine metabolites, highlighting the impact of S-E on various metabolic pathways related to brain health, which could inform future clinical applications.
Unlabelled: and are traditional Chinese herbs used to treat neurodegenerative diseases. This study investigates the combined effects of SC and ER on learning and memory in an Alzheimer's disease rat model and their underlying mechanisms.
Methods: High-performance liquid chromatography was employed to analyze the primary active constituents of Schisandra and Evodia.