Publications by authors named "Jiating Dai"
Background: The clinical application of Doxorubicin (DOX) is constrained due to its cardiotoxic side effects. Oxidative stress and inflammation are crucial mechanisms driving doxorubicin-induced cardiotoxicity (DIC). Peroxiredoxin 5 (Prx5) is central to these inflammatory responses.
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- This study examines the effectiveness and safety of pulsed field ablation (PFA) for treating atrioventricular nodal reentrant tachycardia (AVNRT), focusing on its impact on dual-pathway electrophysiology.
- All 40 patients achieved acute success with PFA, showing an average total ablation time of 7.9 seconds, and 80% experienced induced slow junctional rhythm; however, there were instances of transient atrioventricular block in 17.5% of patients.
- The study concludes that while PFA is highly effective for slow pathway modification, there are risks of transient AV block, especially when performed close to the His bundle,
Article Synopsis
- Doxorubicin (DOX) is limited in its clinical use due to cardiotoxicity caused by oxidative stress and inflammation, while the role of Sulfiredoxin 1 (Srxn1) in this process is not well understood.* -
- In this study, researchers overexpressed Srxn1 in mice and found that it improved cardiac function and reduced injury by decreasing oxidative stress and inflammation caused by DOX treatment.* -
- The study concluded that Srxn1 protects against DOX-induced cardiac damage by modulating the Sirt1/NLRP3 signaling pathway, suggesting it could be a promising therapeutic target for preventing myocardial injury from DOX.*
Article Synopsis
- - The study evaluated the effectiveness and safety of pulsed field ablation (PFA) as a treatment for accessory pathways (APs) in ten conscious patients, achieving a 100% acute procedural success rate with 60% treated in just one application.
- - With an average ablation time of only 6.3 seconds per site, the procedure demonstrated quick results, though one patient experienced brief sinus arrest, which was resolved without lasting complications.
- - The conclusion suggests that PFA is a feasible and efficient method for treating APs, and further research is needed to explore its broader applications in ablation therapies.
Article Synopsis
- - The study investigates the use of a novel focal contact force-sensing pulsed field ablation (PFA) catheter for treating paroxysmal supraventricular tachycardia (PSVT), as prior data on this application is limited.
- - In a pilot study involving 10 patients, successful ablation was achieved quickly without the need for anesthesia, with average procedure times and effective maintenance of sinus rhythm noted over a 6-month follow-up period.
- - No serious adverse events occurred during the procedure or follow-up, highlighting the treatment's safety and efficacy in conscious patients.
Previous studies have reported that visfatin can regulate macrophage polarisation, which has been demonstrated to participate in cardiac remodelling. The aims of this study were to investigate whether visfatin participates in transverse aortic constriction (TAC)-induced cardiac remodelling by regulating macrophage polarisation. First, TAC surgery and angiotensin II (Ang II) infusion were used to establish a mouse cardiac remodelling model, visfatin expression was measured, and the results showed that TAC surgery or Ang II infusion increased visfatin expression in the serum and heart in mice, and phenylephrine or hydrogen peroxide promoted the release of visfatin from macrophages in vitro.
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