Lead toxicity in Nicotiana tabacum L.: Damage antioxidant system and disturb plant metabolism.

In this study, we treated tobacco seedlings with 0, 200, 400, and 800 mg/kg Pb, and explored the response mechanism of tobacco under Pb stress through a combination of growth physiology and metabolomics analysis. The physiological results showed that compared with CK, with the increase of Pb concentration, Pb treatment inhibited tobacco growth, reduced the biomass and photosynthetic pigment content of tobacco seedlings, and severely damaged the chloroplast structure. In addition, compared with CK, the pore conductivity and pore density of Pb800 treatment decreased by 45.

Molybdenum Can Regulate the Expression of Molybdase Genes, Affect Molybdase Activity and Metabolites, and Promote the Cell Wall Bio-Synthesis of Tobacco Leaves.

Molybdenum (Mo) is widely used as a micronutrient fertilizer to improve plant growth and soil quality. However, the interactions between cell wall biosynthesis and molybdenum have not been explored sufficiently. This study thoroughly investigated the regulatory effects of different concentrations of Mo on tobacco cell wall biosynthesis from physiological and metabolomic aspects.

The close association of micronutrients with COVID-19.

Objectives: The present study was conducted to explore the performance of micronutrients in the prediction and prevention of coronavirus disease 2019 (COVID-19).

Methods: This is an observational case-control study. 149 normal controls (NCs) and 214 COVID-19 patients were included in this study.

Clinical prediction of HBV-associated cirrhosis using machine learning based on platelet and bile acids.

Objectives: The present study was conducted to evaluate the performance of serum bile acids in the prediction of cirrhosis in chronic hepatitis B (CHB) population.

Methods: Dysregulated metabolites were explored using untargeted and targeted metabolomic analyses. A machine learning model based on platelet (PLT) and several bile acids was constructed using light gradient boosting machine (LightGBM), to differentiate HBV-associated cirrhosis (BAC) from CHB patients.