Risk Factors and Predictive Analysis of Acute Severe Abdominal Pain After Hepatic Artery Infusion Chemotherapy in Patients with Hepatocellular Carcinoma.

Purpose: To investigate the incidence patterns and risk factors of acute abdominal pain following hepatic arterial infusion chemotherapy (HAIC) in liver cancer patients and develop a preliminary prediction model for post-HAIC abdominal pain.

Patients And Methods: Four hundred hepatocellular carcinoma patients who underwent HAIC at the Affiliated Cancer Hospital of Shandong First Medical University from January 2021 to March 2023 were retrospectively analyzed. The patients were categorized into two groups (abdominal pain and no abdominal pain) based on the occurrence of acute moderate to severe abdominal pain within 24 h after HAIC.

Acridine-based dyes as high-performance near-infrared Raman reporter molecules for cell imaging.

A surface-enhanced Raman scattering (SERS) nanoprobe has been proven to be a promising tool for near-infrared (NIR) biomedical imaging and diagnosis because of its high sensitivity and selectivity. However, the development of NIR SERS reporters has been a bottleneck impeding the preparation of ultrasensitive SERS probes. Herein, we report the design and synthesis of a series of SERS reporters in the NIR region based on 10-methylacridine (AD).