and Variation in Taiwanese General Population and the Cancer Cohort.

and () play essential roles in maintaining genome stability. Rapidly evolving human generates oncogenic variants causing high cancer risk. variation is ethnic-specific in reflecting adaptation and/or effects of genetic drift.

Ethnic-specific variation within Asia population: evidence from over 78 000 cancer and 40 000 non-cancer cases of Indian, Chinese, Korean and Japanese populations.

Background: Germline mutation in 1 and () is genetic predisposition for breast and ovarian cancer. Identification of mutation carriers is a critical step to prevent and treat the cancer in the mutation carriers. Human variation has been well determined as ethnic-specific by studies in Ashkenazi Jewish, Polish and Icelandic populations in the 1990s.