Ammonium Sensing Patch with Ultrawide Linear Range and Eliminated Interference for Universal Body Fluids Analysis.

Ammonium level in body fluids serves as one of the critical biomarkers for healthcare, especially those relative to liver diseases. The continuous and real-time monitoring in both invasive and non-invasive manners is highly desired, while the ammonium concentrations vary largely in different body fluids. Besides, the sensing reliability based on ion-selective biosensors can be significantly interfered by potassium ions.

Myocardial delivery of miR30d with peptide-functionalized milk-derived extracellular vesicles for targeted treatment of hypertrophic heart failure.

miR30d has been shown to reverse cardiac hypertrophy. However, effective delivery of miR30d to the heart is challenging. Here, we engineered milk-derived extracellular vesicles (mEVs) by surface functionalization with an ischemic myocardium-targeting peptide (IMTP) and encapsulated miR30d to develop a formulation, the miR30d-mEVs, enabling targeted delivery of miR30d to the injured heart.