Continuous Electrosynthesis of Pure HO Solution with Medical-Grade Concentration by a Conductive Ni-Phthalocyanine-Based Covalent Organic Framework.

Electrosynthesis of HO provides an environmentally friendly alternative to the traditional anthraquinone method employed in industry, but suffers from impurities and restricted yield rate and concentration of HO. Herein, we demonstrated a Ni-phthalocyanine-based covalent-organic framework (COF, denoted as ) with a higher inherent conductivity of 1.14 × 10 S m, which exhibited an ultrahigh current density of 530 mA cm with a Faradaic efficiency (HO) of ∼100% at a low cell voltage of 3.

Integration of Plasmonic Ag(I) Clusters and Fe(II) Porphyrinates into Metal-Organic Frameworks for Efficient Photocatalytic CO Reduction Coupling with Photosynthesis of Pure HO.

Efficient photocatalytic CO reduction coupled with the photosynthesis of pure HO is a challenging and significant task. Herein, using classical CO photoreduction site iron porphyrinate as the linker, Ag(I) clusters were spatially separated and evenly distributed within a new metal-organic framework (MOF), namely AgTPyP-Fe. With water as electron donors, AgTPyP-Fe exhibited remarkable performances in artificial photosynthetic overall reaction with CO yield of 36.

Highly Efficient Electrosynthesis of Urea from CO and Nitrate by a Metal-Organic Framework with Dual Active Sites.

Electrosynthesis of urea from CO and NO is a sustainable alternative to energy-intensive industrial processes. The main challenge hindering the progress of this technology lies in the development of advanced electrocatalysts that efficiently utilize abundant, low-cost CO and nitrogen sources to yield urea with both high Faradaic efficiency (FE) and current density. In this work, we designed and prepared a new two-dimensional metal-organic framework (MOF), namely PcNi-Fe-O, constructed by nickel-phthalocyanine (NiPc) ligands and square-planar FeO nodes, as the electrocatalyst for urea electrosynthesis.

Efficient Capture and Electroreduction of Dilute CO into Highly Pure and Concentrated Formic Acid Aqueous Solution.

High-purity CO rather than dilute CO (15 vol %, CO/N/O = 15:80:5, v/v/v) similar to the flue gas is currently used as the feedstock for the electroreduction of CO, and the liquid products are usually mixed up with the cathode electrolyte, resulting in high product separation costs. In this work, we showed that a microporous conductive Bi-based metal-organic framework (, HHTP = 2,3,6,7,10,11-hexahydroxytriphenylene) can not only efficiently capture CO from the dilute CO under high humidity but also catalyze the electroreduction of the adsorbed CO into formic acid with a high current density of 80 mA cm and a Faradaic efficiency of 90% at a very low cell voltage of 2.6 V.

Utilisation of carbon dioxide and nitrate for urea electrosynthesis with a Cu-based metal-organic framework.

It is important and challenging to utilise CO and NO as a feedstock for electrosynthesis of urea. Herein, we reported a stable 2D metal-organic framework (MOF) Cu-HATNA, possessing planar CuO active sites, as an efficient electrocatalyst for coupling CO and NO into urea, achieving a high yield rate of 1.46 g h g with a current density of 44.

Continuously Producing Highly Concentrated and Pure Acetic Acid Aqueous Solution via Direct Electroreduction of CO.

It is crucial to achieve continuous production of highly concentrated and pure C chemicals through the electrochemical CO reduction reaction (eCORR) for artificial carbon cycling, yet it has remained unattainable until now. Despite one-pot tandem catalysis (dividing the eCORR to C into two catalytical reactions of CO to CO and CO to C) offering the potential for significantly enhancing reaction efficiency, its mechanism remains unclear and its performance is unsatisfactory. Herein, we selected different CO-to-CO catalysts and CO-to-acetate catalysts to construct several tandem catalytic systems for the eCORR to acetic acid.

Highly Efficient Electroreduction of CO to Ethanol via Asymmetric C-C Coupling by a Metal-Organic Framework with Heterodimetal Dual Sites.

The electroreduction of CO into value-added liquid fuels holds great promise for addressing global environmental and energy challenges. However, achieving highly selective yielding of multi-carbon oxygenates through the electrochemical CO reduction reaction (eCORR) is a formidable task, primarily due to the sluggish asymmetric C-C coupling reaction. In this study, a novel metal-organic framework () with unprecedented heterometallic Sn···Cu dual sites (namely, a pair of SnNO and CuN sites bridged by -N atoms) was designed to overcome this limitation.

Simultaneous Capture of CO Boosting Its Electroreduction in the Micropores of a Metal-organic Framework.

Integration of CO capture capability from simulated flue gas and electrochemical CO reduction reaction (eCO RR) active sites into a catalyst is a promising cost-effective strategy for carbon neutrality, but is of great difficulty. Herein, combining the mixed gas breakthrough experiments and eCO RR tests, we showed that an Ag cluster-based metal-organic framework (1-NH , aka Ag bpy-NH ), simultaneously possessing CO capture sites as "CO relays" and eCO RR active sites, can not only utilize its micropores to efficiently capture CO from simulated flue gas (CO  : N =15 : 85, at 298 K), but also catalyze eCO RR of the adsorbed CO into CO with an ultra-high CO conversion of 60 %. More importantly, its eCO RR performance (a Faradaic efficiency (CO) of 96 % with a commercial current density of 120 mA cm at a very low cell voltage of -2.

Self-Accelerating Effect in a Covalent-Organic Framework with Imidazole Groups Boosts Electroreduction of CO to CO.

Solvent effect plays an important role in catalytic reaction, but there is little research and attention on it in electrochemical CO reduction reaction (eCO RR). Herein, we report a stable covalent-organic framework (denoted as PcNi-im) with imidazole groups as a new electrocatalyst for eCO RR to CO. Interestingly, compared with neutral conditions, PcNi-im not only showed high Faraday efficiency of CO product (≈100 %) under acidic conditions (pH ≈ 1), but also the partial current density was increased from 258 to 320 mA cm .

Precise Engineering of a Se/Te Nanochaperone for Reinvigorating Cancer Radio-Immunotherapy.

Facilely synthesized nanoradiosensitizers with well-controlled structure and multifunctionality are greatly desired to address the challenges of cancer radiotherapy. In this work, a universal method is developed for synthesizing chalcogen-based TeSe nano-heterojunctions (NHJs) with rod-, spindle-, or dumbbell-like morphologies by engineering the surfactant and added selenite. Interestingly, dumbbell-shaped TeSe NHJs (TeSe NDs) as chaperone exhibit better radio-sensitizing activities than the other two nanostructural shapes.

Improvement of catalytic activity of sorbose dehydrogenase for deoxynivalenol degradation by rational design.

Deoxynivalenol (DON) is the most frequently contaminated mycotoxin in food and feed worldwide, causing significant economic losses and health risks. Physical and chemical detoxification methods are widely used, but they cannot efficiently and specifically remove DON. In the study, the combination of bioinformatics screening and experimental verification confirmed that sorbose dehydrogenase (SDH) can effectively convert DON to 3-keto-DON and a substance that removes four hydrogen atoms for DON.

Cyclic Trinickel(II) Clusters in a Metal-Azolate Framework for Efficient Overall Water Splitting.

Herein, a stable metal-azolate framework with cyclic trinickel(II) clusters, namely [Ni (μ -O)(BTPP)(OH)(H O) ] (Ni-BTPP, H BTPP=1,3,5-tris((1H-pyrazol-4-yl)phenylene)benzene), achieved a current density of 50 mA cm at a cell voltage of 1.8 V in 1.0 M KOH solution, while the current density of 20%Pt/C@NF||IrO @NF is just 35.

Real-Time Forest Fire Detection by Ensemble Lightweight YOLOX-L and Defogging Method.

Forest fires can destroy forest and inflict great damage to the ecosystem. Fortunately, forest fire detection with video has achieved remarkable results in enabling timely and accurate fire warnings. However, the traditional forest fire detection method relies heavily on artificially designed features; CNN-based methods require a large number of parameters.

Synergistic Effect in a Metal-Organic Framework Boosting the Electrochemical CO Overall Splitting.

It is a very important but still challenging task to develop bifunctional electrocatalysts for highly efficient CO overall splitting. Herein, we report a stable metal-organic framework (denoted as -), composed of (2,3,9,10,16,17,23,24-octahydroxyphthalocyaninato)nickel(II) (PcNi-(O)) ligands and the planar CoO nodes, for CO overall splitting. When working as both cathode and anode catalysts (i.

Correction: Selenium-driven enhancement of synergistic cancer chemo-/radiotherapy by targeting nanotherapeutics.

Correction for 'Selenium-driven enhancement of synergistic cancer chemo-/radiotherapy by targeting nanotherapeutics' by Xinxin Liu , , 2021, , 4691-4700, https://doi.org/10.1039/d1bm00348h.

Rational Design of Metal-Organic Frameworks for Electroreduction of CO to Hydrocarbons and Carbon Oxygenates.

Since CO can be reutilized by using renewable electricity in form of product diversity, electrochemical CO reduction (ECR) is expected to be a burgeoning strategy to tackle environmental problems and the energy crisis. Nevertheless, owing to the limited selectivity and reaction efficiency for a single component product, ECR is still far from a large-scale application. Therefore, designing high performance electrocatalysts is the key objective in CO conversion and utilization.

Single-Product Faradaic Efficiency for Electrocatalytic of CO to CO at Current Density Larger than 1.2 A cm in Neutral Aqueous Solution by a Single-Atom Nanozyme.

Electroreduction of CO to CO is a promising approach for the cycling use of CO , while it still suffers from impractical current density and durability. Here we report a single-atom nanozyme (Ni-N -C) that achieves industrial-scale performance for CO -to-CO conversion with a Faradaic efficiency (FE) exceeded 97 % over -0.8--2.

In situ-transition nanozyme triggered by tumor microenvironment boosts synergistic cancer radio-/chemotherapy through disrupting redox homeostasis.

Disrupting redox homeostasis in the tumor microenvironment (TME), like excessive HO, glutathione (GSH) and weak acidity, has been proved as an effective tumor therapeutic strategy. Herein, we constructed a TME-responsive nanozyme, DOX@HMSN/MnO(R), with reversible Mn/Mn transition in situ triggered by TME to perturb the intrinsic redox homeostasis and catalyze reactive oxygen species (ROS) overproduction. In addition, this nanozyme could react with excess GSH in TME to produce GSSG, resulting in the consumption of reducing agents to suppress ROS clearance.

A Stable and Conductive Covalent Organic Framework with Isolated Active Sites for Highly Selective Electroreduction of Carbon Dioxide to Acetate.

Electroreduction of CO to acetate provides a promising strategy to reduce CO emissions and store renewable energy, but acetate is usually a by-product. Here, we show a stable and conductive two-dimensional phthalocyanine-based covalent-organic framework (COF) as an electrocatalyst for reduction of CO to acetate with a single-product Faradaic efficiency (FE) of 90.3(2)% at -0.

Bioactive Nanoenzyme Reverses Oxidative Damage and Endoplasmic Reticulum Stress in Neurons under Ischemic Stroke.

Designing translational antioxidative agents that could scavenge free radicals produced during reperfusion in brain ischemia stroke and alleviate neurologic damage is the main objective for ischemic stroke treatment. Herein, we explored and simply synthesized a biomimic and translational MnO nanoenzyme (HSA-MnO) to constrain ischemic stroke reperfusion-induced nervous system injury. This nanosystem exhibits reduced levels of inflammation and prolonged circulation time and potent ROS scavenging activities.

A Cu(111)@metal-organic framework as a tandem catalyst for highly selective CO electroreduction to CH.

Here, we report an improved tandem catalytic mechanism for electroreduction of CO to CH. Cu(111) nanoparticles with an average size of 5.5 ± 0.

Electrostatic Attraction-Driven Assembly of a Metal-Organic Framework with a Photosensitizer Boosts Photocatalytic CO Reduction to CO.

Reducing CO into fuels via photochemical reactions relies on highly efficient photocatalytic systems. Herein, we report a new and efficient photocatalytic system for CO reduction. Driven by electrostatic attraction, an anionic metal-organic framework (HHTP = 2,3,6,7,10,11-hexahydroxytriphenylene) as host and a cationic photosensitizer [Ru(phen)] (phen = 1,10-phenanthroline) as guest were self-assembled into a photocatalytic system , which showed high activity for photocatalytic CO reduction under laboratory light source (CO production rate of 130(5) mmol g h, selectivity of 92.

Anti-Inflammatory Nanotherapeutics by Targeting Matrix Metalloproteinases for Immunotherapy of Spinal Cord Injury.

Neuroinflammation is critically involved in the repair of spinal cord injury (SCI), and macrophages associated with inflammation propel the degeneration or recovery in the pathological process. Currently, efforts have been focused on obtaining efficient therapeutic anti-inflammatory drugs to treat SCI. However, these drugs are still unable to penetrate the blood spinal cord barrier and lack the ability to target lesion areas, resulting in unsatisfactory clinical efficacy.