Publications by authors named "Jiaru Fu"
Anxiety disorders are one of the most epidemic and chronic psychiatric disorders. An incomplete understanding of anxiety pathophysiology has limited the development of highly effective drugs against these disorders. GPR17 has been shown to be involved in multiple sclerosis and some acute brain injury disorders.
View Article and Find Full Text PDFEffects of drug-induced liver injury on the in vivo fate of liposomes.
Eur J Pharm Biopharm
August 2024
Article Synopsis
- Liposomes are highly studied for targeted drug delivery, but their effectiveness can be impacted by liver conditions, which are often overlooked in research.
- This study focused on how drug-induced liver injury (DILI) affects the pharmacokinetics and distribution of liposomes using animal models of liver damage.
- Results showed that liposomes have longer circulation in the blood and greater accumulation in the liver during DILI, with macrophages remaining key players in their uptake, raising both opportunities and concerns for clinical applications in liver-injured patients.
Polyethylene glycol (PEG) plays important roles in stabilizing and lengthening circulation time of lipid nanoparticle (LNP) vaccines. Nowadays various levels of PEG antibodies have been detected in human blood, but the impact and mechanism of PEG antibodies on the in vivo performance of LNP vaccines has not been clarified thoroughly. By illustrating the distribution characteristics of PEG antibodies in human, the present study focused on the influence of PEG antibodies on the safety and efficacy of LNP-mRNA vaccine against COVID-19 in animal models.
View Article and Find Full Text PDF