The Recent Research Progress of the Tumor mRNA Vaccine.

Tumors have long posed a significant threat to human life and health, and the messenger ribonucleic acid (mRNA) vaccine is seen as an attractive approach for cancer immunotherapy due to its developmental simplicity, rapid manufacture, and increased immune safety and efficiency. In this review, we have summarized details of the developmental history of mRNA vaccines, discussed the basic molecular structure and the effect on the stable and translation level of mRNA, analyzed the underlying immune efficiency and mechanisms on tumors, and assessed the current status of clinical research. We explored the treatment and application prospects of mRNA vaccines, aiming to provide perspectives on the future of mRNA tumor vaccines for ongoing clinical research.

Regulation and Mechanism of miR-518d through the PPAR-Mediated NF-B Pathway in the Development of Gestational Diabetes Mellitus.

Objectives: To observe the role of miR-518d in pregnant women with gestational diabetes mellitus (GDM) and its adjusting effects on PPAR and to explore the regulatory mechanisms of the NF-B pathway in the development and progression of GDM.

Methods: Placenta tissues and peripheral plasma were obtained from pregnant women with normal pregnancy and GDM, respectively, followed by the detections of miR-518d contents by RT-PCR and the expression levels of inflammatory factors using ELISA. Human placenta trophoblast cells (HTR8/SVneo) were cultured under the conditions of physiological glucose (PG group) and high glucose level (HG group).

[Correlation between thyroid hormones and renal function in severe pre-eclampsia patients with hypothyroidism].

Objective: To study effects of different degree of hypothyroidism in severe pre-eclampsia (S-PE) pregnant women on renal function and the correlation between them.

Methods: 46 S-PE patients with subclinical hypothyroidism (SCH) registered for treatment in the Shengjing Hospital of China Medical University from May 2011 to March 2013 were selected into SCH group, and 23 S- PE with overt hypothyroidism (OH) were selected into OH group, and 109 S- PE with normal thyroid stimulating hormone (TSH) levels were selected into simple group. Thyroid hormone and kidney function tests were analyzed in pregnant women with S-PE.

[Thyroid hormone changes in women with pre-eclampsia and its relationship with the presence of pre-eclampsia].

Objective: To study thyroid hormone changes in women with pre-eclampsia patients, the characteristics of thyroid disease and its relationship with pre-eclampsia.

Methods: From May 2011 to December 2012 171 patients with pre-eclampsia who delivered in Shengjing Hospital of China Medical University were recruited as pre-eclampsia(PE) group, among which 114 cases were defined as early onset pre-eclampsia (EP) group and 57 cases were defined as late onset pre-eclampsia (LP) group. And 171 healthy women with same age and same stage of pregnancy were selected as the control group.

The pattern of thyroid function of subclinical hypothyroid women with levothyroxine treatment during pregnancy.

In this study, we researched the pattern of thyroid function of subclinical hypothyroid (SCH) women with levothyroxine (LT4) throughout pregnancy and determined the optimal dosages of LT4 for such women. 56 SCH pregnant women were followed regularly prospectively. They were divided into three groups: group A (n = 29.

The prevalence of thyroid disorders during early pregnancy in China: the benefits of universal screening in the first trimester of pregnancy.

Context: Maternal thyroid disorders during early pregnancy can influence pregnancy outcome and fetal development. The recent Endocrine Society Clinical Practice Guideline recommends a case-finding approach in which pregnant women who are at high risk for developing thyroid disease are tested.

Objective: The purpose of this study was to use the first trimester-specific reference intervals of thyroid-related hormones to explore the prevalence of thyroid dysfunction during early pregnancy and to analyze effectiveness of different screening strategies.

[A clinical study on gestational transient thyrotoxicosis].

Objective: To investigate the prevalence of gestational transient thyrotoxicosis (GTT) and analyze the cause of thyrotoxicosis encountered in this period.

Methods: An epidemiologic survey in ten hospitals in Shenyang was performed and 534 pregnant women during the first trimester of pregnancy filled questionnaire, received physical examination and had serum thyroid-stimulating hormone (TSH), free T(4) (FT(4)), free T(3) (FT(3)), thyroid peroxidase antibody (TPOAb), thyrotrophin receptor antibody (TRAb), and human chorionic gonadotrophin (hCG) tests.

Results: (1) The total prevalence of thyrotoxicosis was 9.