Publications by authors named "Jiaqing Cheng"
Although tumor cell-derived microparticles (MPs) vaccines have reportedly induced antitumor immune reactions for various cancers, the mechanism by which MPs derived from Hepa1-6 cells are taken up by dendritic cells (DCs) and provide the MPs antigens message to CD8+ T cells to exert their anti-hepatocellular carcinoma (HCC) effects remain unclear. Furthermore, the role of MPs in combination with the small-molecule drug MSI-1436, an inhibitor of protein tyrosine phosphatase 1B (PTP1B), in HCC has not yet been reported. In this study, protein mass spectrometry combined with cytology revealed that MPs are mainly taken up by DCs via the clathrin-mediated endocytosis and phagocytosis pathway and localized mainly in lysosomes.
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- Cellular senescence (CS) is linked to cancer progression, and this study explored its impact on gastric cancer (GC) by analyzing CS-related genes using the CellAge and TCGA databases.
- Researchers used a clustering method to categorize GC patients into two distinct subtypes (C1 and C2) based on these genes, revealing significant differences in gene expression, survival rates, and immune environments between the subtypes.
- A risk model was created identifying eight key genes, allowing for the classification of patients into high-risk (poor prognosis and greater drug resistance) and low-risk groups (better outcomes and potential benefits from immunotherapy).