Passive Prophylactic Administration with a Single Dose of Anti-Fel d 1 Monoclonal Antibodies REGN1908-1909 in Cat Allergen-induced Allergic Rhinitis: A Randomized, Double-Blind, Placebo-controlled Clinical Trial.

Sensitization to Fel d 1 ( allergen 1) contributes to persistent allergic rhinitis and asthma. Existing treatment options for cat allergy, including allergen immunotherapy, are only moderately effective, and allergen immunotherapy has limited use because of safety concerns. To explore the relationship among the pharmacokinetic, clinical, and immunological effects of anti-Fel d 1 monoclonal antibodies (REGN1908-1909) in patients after treatment.

Low potential detection of indole-3-acetic acid based on the peroxidase-like activity of hemin/reduced graphene oxide nanocomposite.

An amperometric sensor was firstly established for the detection of indole-3-acetic acid (IAA) at low potential based on the hemin/reduced graphene oxide (hemin/rGO) composite. The hemin/rGO nanocomposite was prepared by a simple and facile hydrothermal method without using any reducing agent. It exhibited peroxidase-like activity for the catalytic oxidation of IAA in the presence of oxygen.

Hierarchical porous TiO2 fabricated from magnolia grandiflora petals templates for the immobilization and electrical wiring of proteins.

Hierarchical porous titanium dioxide (hp-TiO2) was prepared using natural magnolia grandiflora petals as templates and was further employed for the immobilization of horseradish peroxidase (HRP). Scanning electron microscopy (SEM) and nitrogen adsorption-desorption measurement revealed the wrinkled and porous structure of the obtained hp-TiO2. Fourier transform infrared spectroscopy (FT-IR) indicated the effective immobilization and conformation retention of HRP on hp-TiO2.

Electrochemical method assisted immobilization and orientation of myoglobin into biomimetic brij 56 film and its direct electrochemistry study.

A simple cyclic voltammetric method was applied to assemble and orient a model protein, namely, myoglobin (Mb), into a biocompatible Brij 56 film. Ultraviolet-visible and circular dichroism spectra indicated that Mb in Brij 56 matrix preserved its secondary structure. Fourier transform infrared spectra confirmed the formation of hydrogen bonds between Mb and Brij 56.

Forchlorfenuron detection based on its inhibitory effect towards catalase immobilized on boron nitride substrate.

An enzymatic procedure based on a catalase biosensor for the detection of forchlorfenuron (CPPU) has been reported in this work. Catalase was immobilized on boron nitride (BN) sheets dispersed in chitosan by adsorption. The immobilized catalase exhibited direct electron transfer character and excellent electrocatalytic activity towards H2O2 reduction.

Preparation, structural diversity and characterization of a family of Cd(II)-organic frameworks.

Two Cd(II)-organic frameworks based on 5-iodoisophthalate (IIP(2-)), {[Cd(IIP)(bte)(H2O)]·H2O}n (1) and [Cd(IIP)(bpp)(H2O)]n (2), were obtained either at an ambient temperature or under solvothermal conditions at 120 °C in the presence of 1,4-bis(1,2,4-triazol-1-yl)ethane (bte) and 1,3-bis(4-pyridyl)propane (bpp) as auxiliary ligands, respectively. 1 is a novel discrete single-walled Cd(II)-organic tube (SWCOT) which further extends into a 3D supramolecular interdigitated microporous columnar architecture supported by C-I···I halogen bonds and hydrogen bonds, while 2 exhibits an interesting two-fold interpenetrated 3D diamond network architecture. When the auxiliary ligands bte or bpp were replaced by a longer spacer ligand with more flexibility, 1,4-bis(triazol-1-ylmethyl)benzene (bbtz), the unique discrete single-walled Cd(II)-organic nanotube (SWCONT), {[Cd(IIP)(bbtz)(H2O)]·H2O}n (3), which further extends into a 3D supramolecular microporous framework supported by face-to-face π···π stacking interactions and hydrogen bonds, was generated at room temperature.