Publications by authors named "Jiaqi Wang"

Hepatocellular carcinoma (HCC) is a highly malignant cancer and lacks effective therapeutic targets. The role of LIM/homeobox protein Lhx3 (LHX3) has been extensively studied in various tumor tissues, where it has been identified as a promoter of tumorigenesis and malignancy. However, the specific functional role and potential mechanism of LHX3 in human HCCs are not clearly clarified.

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Objective: The incidence of vertebral fragile fractures peaked among the elderly population, and identifying individuals at high risk of vertebral fractures and promptly instituting preventions are of critical importance. This study aims to determine the efficacy and values of Hounsfield unit (HU) values, vertebral bone quality (VBQ) scores, bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA), and quantitative computed tomography (QCT) to discriminate between patients with and without vertebral fractures.

Methods: A thorough search was conducted across PubMed, EMBASE, Cochrane Library, Web of Science, CNKI, and Wan Fang Database to identify potential studies that met the eligibility criteria.

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The de-ubiquitinase USP33 has been shown to possess either tumour-promoting or inhibitory effect on human cancer cells. However, all these findings are mainly based on in vitro cell culture models, and the in vivo evidence, which is more plausible to digest the functional role of USP33 in carcinogenic process, is still lacking. Here, we demonstrate that USP33 modulates DNA damage responses including cell cycle arrest and apoptosis induction through associating with p53.

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Dissolved organic carbon (DOC) and its biodegradability (BDOC%) in aquatic ecosystems significantly impact the global carbon cycle, varying greatly across rivers, lakes, and estuaries due to environmental and anthropogenic factors. However, a thorough understanding of these variations is still lacking. This study investigated the interactions between climate, hydrology, physiography, soil, land cover, and human activity on DOC dynamics in rivers, lakes, and estuaries.

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Macrophages that acquire an immunosuppressive phenotype play a crucial role in establishing the pre-metastatic niche (PMN), which is essential for facilitating breast cancer metastasis to distant organs. Our study showed that increased activity of the aryl hydrocarbon receptor (AHR) in lung macrophages plays a crucial role in establishing the immunosuppressive PMN in breast cancer. Specifically, AHR activation led to high expression of PD-L1 on macrophages by directly binding to the promoter of Pdl1.

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Epidemiological studies and a recent Mendelian randomization (MR) study have identified an association between low bone mass and an increased risk of scoliosis. Previous research suggests that bone loss in patients with scoliosis may be related to the RANK-RANKL-OPG system. This study is to investigate whether a causal relationship exists between the RANK-RANKL-OPG system and the development of scoliosis.

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Considering the demand for the construction of a sustainable future, it is essential to endow the conventional thermoset silicone adhesive with reuse capability and recyclability. Although various research attempts have been made by incorporating reversible linkages, developing sustainable silicone adhesives by natural linkers is still challenging, as the interface between the natural linker and the silicone is historically difficult. We exploited the possibility of utilizing -lipoic acid, a natural linker, to construct a sustainable silicone adhesive.

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Background: In the treatment of depression, medication plays a crucial role. However, insufficient patient adherence to medication often results in unsatisfactory treatment outcomes, increasing both the recurrence and rehospitalization rates of depression, and consequently imposing a greater economic burden on the healthcare system.

Objectives: Our objective was to examine the impact of pharmacogenomic testing on medication adherence and antidepressant switching rates among individuals diagnosed with depression.

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Understanding the ultrafast excitation, detection, transportation, and manipulation of nanoscale spin dynamics in the terahertz (THz) frequency range is critical to developing spintronic THz optoelectronic nanodevices. However, the diffraction limitation of the sub-millimeter waves - THz wavelengths - has impaired experimental investigation of spintronic THz nano-emission. Here, we present an approach to studying laser THz emission nanoscopy from W|CoFeB|Pt metasurfaces with ∼60-nm lateral spatial resolution.

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The ability to electrically manipulate spin states in magnetic materials is essential for the advancement of energy-efficient spintronic device, which is typically achieved in systems composed of a spin source and a magnetic target, where the magnetic state of the target is altered by a charge current. While theories suggest that ferromagnets could function as more versatile spin sources, direct experimental studies involving only the spin source and target layers have been lacking. Here electrical manipulation of spin states in noncolinear antiferromagnet MnSn using ferromagnets (Ni, Fe, NiFe, CoFeB) as the spin sources is reported.

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Platinum (Pt) catalyst performance loss caused by a high local oxygen transport resistance is an urgent problem to be solved for proton exchange membrane fuel cells (PEMFCs). Rationally arranging Pt particles on carbon support is the primary approach for reducing mass transport resistance. Herein, using a unique method coupling Hybrid Reverse Monte Carlo, molecular dynamics simulations, and experimental measurements, a Pt particle arrangement strategy is proposed to reduce local oxygen transport resistance, based on a molecular-level understanding of its impact.

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Article Synopsis
  • Chiral organic-inorganic hybrid perovskite nanocrystals are emerging as effective materials for producing circularly polarized light due to their high photoluminescence efficiency and charge-carrier mobility.
  • * Researchers developed bichiral formamidinium lead bromide (FAPbBr) nanocrystals that successfully create circularly polarized LEDs at room temperature, utilizing the collaboration between a chiral interior spacer and surface ligand.
  • * The resulting LEDs show increased luminescence asymmetry and external quantum efficiency, highlighting the potential for these nanocrystals in future chiroptoelectronic technologies.
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This study aimed to develop a compensatory growth model using growing beef cattle by changing dietary protein and to investigate the underlying mechanisms of compensatory protein deposition in muscle tissue. Twelve Charolais bulls were randomly assigned to one of two groups with two periods: 1) a control group (CON) fed a 13% crude protein (CP) diet for 6 weeks; 2) a treatment group (REC) fed a 7% CP diet for 4 weeks (restriction period) and fed a 13% CP diet in the following 2 weeks (re-alimentation period). Growth performance, digestibility, nitrogen balance, targeted metabolomics of amino acids (AA) in plasma, and transcriptional profiling in muscle tissue were analyzed.

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Lakes are sources of atmospheric carbon dioxide (CO), contributing to global climate change. Temporal variations in lake CO emissions are pronounced, with algal growth and precipitation identified as important drivers. Eutrophic lakes often act as atmospheric CO sinks during the growing season.

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Article Synopsis
  • - Metformin, commonly used for type 2 diabetes, enters the environment through urban sewage, producing disinfection byproducts like compounds C and Y, which may be toxic and harmful to health.
  • - ADMET predictions showed compounds C and Y could cause liver damage and cross the blood-brain barrier, with significant differences in acute toxicity between male and female mice tested.
  • - A new method was developed for detecting compound C in water, highlighting the need for better monitoring of its potential health impacts as it can also disrupt gut microbiota and affect brain and liver function.
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  • Spore-forming bacteria in the dairy industry are resilient and can survive heating, leading to milk spoilage and contamination via biofilms.
  • A study analyzed 165 raw milk samples from six regions in China across all seasons using metagenomics, identifying 207 species of spore-forming bacteria, predominantly from the genera Bacillus and Paenibacillus darwinianus.
  • Seasonal changes had a more significant effect than regional differences on bacterial composition, with spring and summer samples showing more unique species, highlighting the need for tailored prevention strategies in handling raw milk.
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Article Synopsis
  • Adipose tissue is classified into three types: brown adipose tissue (BAT), white adipose tissue (WAT), and beige adipose tissue, each serving unique roles in energy metabolism.
  • Extracellular vesicles (EVs) facilitate communication between cells and carry various biomolecules, but comparative analysis of EVs from different adipose tissues has not been fully examined.
  • The study focuses on isolating small extracellular vesicles (sEVs) from various adipose tissues, analyzing their microRNA content, and exploring how these miRNAs may influence intercellular communication and the specific functions of adipose tissues.
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Alfalfa is primarily stored as silage or hay in livestock production. Previous research has shown that the storage method of grass significantly influences milk composition. This study aimed to investigate milk production performance and lipid composition in dairy cows fed diets consisting of alfalfa hay or alfalfa silage as roughage.

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Terrestrial ecosystems represent the most direct and principal reservoirs of plastic contamination on Earth. The toxic effects of microplastic exposure on terrestrial plants have been analyzed from the perspectives of direct toxicity, indirect toxicity, and combined toxicity with other pollutants. By investigating the impacts on the growth, behavior, and oxidative stress responses of soil animals, the toxicological patterns of microplastics have been elucidated.

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Background: Pediatric epilepsy is the most common disease of pediatric neurological diseases in China. Current demographic characteristics and economic burdens are needed to guide public health policy. In this study, we provide the demographic characteristics and economic burden of pediatric epilepsy patients in China from 2016 to 2021, and describe the change trend and correlation of demographic characteristics and economic burden by province.

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In this paper, chiral aryl iodides were used for the first time to catalyze the formation of C-O and C-N bonds of inactive olefins to obtain optically active aminolactone derivatives. The reaction is compatible with various substituted alkenyl carboxylic acid substrates. This method usually shows high activity and enantioselectivity, with a yield of up to 83% and an ee of up to 99%.

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Article Synopsis
  • - Alzheimer's disease (AD) may be linked to chronic infections, specifically from Toxoplasma gondii, as researchers found higher Toxoplasma-specific antibodies in AD patients compared to healthy controls.
  • - A study involving serum samples from 109 AD patients and 114 healthy individuals used ELISA tests to detect antibodies and applied logistic regression to analyze risk factors.
  • - The findings suggest chronic Toxoplasma infection could be a significant risk factor for developing AD, highlighting the importance of considering infectious diseases in understanding AD's onset.
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Acetaldehyde is a key carbonyl by-product during red wine alcoholic fermentation; it is reactive and takes part in certain reactions involving anthocyanin. The aim of this study was to investigate the influence of SO and condensed tannin on the acetaldehyde accumulation of () during alcoholic fermentation and the ripple effect on wine anthocyanin. In this study, six sets of Cabernet Sauvignon alcoholic fermentation with two different sulfur levels (HS and LS) were carried out by adding exogenous condensed tannins before fermentation (T0) in the acetaldehyde rise period (TA) of and at the end of fermentation (TE), separately.

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