Advances and prospects of tumor immunotherapy mediated by immune cell-derived biomimetic metal-organic frameworks.

The clinical translational success of nanomedicine and immunotherapy has already proved the immense potential in the field of nanotechnology and immunization. However, the development of nanomedicine is confronted with challenges such as potential toxicity and unclear nano-bio interactions. The efficacy of immunotherapy is limited to only a few groups.

Multi-functional, conformal systems with ultrathin crystalline-silicon-based bioelectronics for characterization of intraocular pressure and ocular surface temperature.

Technologies that established in vivo evaluations of soft-tissue biomechanics and temperature are essential to biological research and clinical diagnostics, particularly for a wide range of eye-related diseases such as glaucoma. Of importance are advanced bioelectronic devices for high-precise monitoring of intraocular pressure (IOP) and various ocular temperatures, as clinically proven uses for glaucoma diagnosis. Existing characterization methods are temporary, single point, and lack microscale resolution, failing to measure continuous IOP fluctuation across the long-term period.

LC-MS untargeted metabolomics reveals metabolic disturbance and ferroptosis in MWCNTs-induced hepatotoxicity of Cyprinus carpio.

In recent years, there is a great concern about the potential adverse effects of carbon nanotubes (CNTs) on the aquatic systems due to their increasingly extensive application. In this study, juvenile Cyprinus carpio were exposed to multi-walled CNTs (MWCNTs) at concentrations of 0, 0.25, and 2.

Tool State Recognition Based on POGNN-GRU under Unbalanced Data.

Accurate recognition of tool state is important for maximizing tool life. However, the tool sensor data collected in real-life scenarios has unbalanced characteristics. Additionally, although graph neural networks (GNNs) show excellent performance in feature extraction in the spatial dimension of data, it is difficult to extract features in the temporal dimension efficiently.

The association between physical fitness and mental health among college students: a cross-sectional study.

Introduction: Physical inactivity and mental health disorders are emerging threats to public health in China. Previous research on links between exercise and mental wellbeing have focused on clinical populations, with little evidence from the general population, particularly younger adults. We aimed to investigate associations between physical fitness and mental health in Chinese college students.

A comparative study of F-PSMA-1007 PET/CT and pelvic MRI in newly diagnosed prostate cancer.

Purpose: To evaluate the difference in the diagnostic efficacy of F-PSMA-1007 PET/CT and pelvic MRI in primary prostate cancer, as well as the correlation between the two methods and histopathological parameters and serum PSA levels.

Methods: A total of 41 patients with suspected prostate cancer who underwent F-PSMA-1007 PET/CT imaging in our department from 2018 to 2023 were retrospectively collected. All patients underwent F-PSMA-1007 PET/CT and MRI scans.

Bacterial composition and physicochemical characteristics of sorghum based on environmental factors in different regions of China.

The fermentation process for Jiang-flavored baijiu using sorghum as the raw material involves a variety of microorganisms. However, the specific physicochemical characteristics of sorghum and microbial composition on its surface have not been fully elucidated. We aimed to perform a comprehensive comparative analysis of the variations in physicochemical properties and surface microflora in waxy sorghum samples from three prominent production regions in China (Renhuai, Jinsha, and Duyun).

Alginate and chitosan surface coating reduces the phytotoxicity of CeO nanoparticles to duckweed (Lemna minor L.).

Little is known about the effect of surface coatings on the fate and toxicity of CeO nanoparticles (NPs) to aquatic plants. In this study, we modified nCeO with chitosan (Cs) and alginate (Al) to obtain positively charged nCeO@Cs and negatively charged nCeO@Al, respectively, and exposed them to a representative aquatic plant, duckweed (Lemna minor L.).

Posterior capsular radial sign: a novel method to confirm anterior vitreous cortex resection in phacovitrectomy.

Background: The main purpose of this paper is to introduce a method that can accurately locate the posterior capsule of the lens to facilitate a relatively complete resection of the anterior vitreous body.

Methods: A total of 51 patients in the experimental group and control group were enrolled in this study. Phacoemulsification combined with vitrectomy was performed in all cases.

Metal-phenolic network as precursor complex coating for forward osmosis membrane with enhanced antifouling property.

In this study, a multi-functional layer was developed based on the commercially available cellulose triacetate (CTA) forward osmosis (FO) membrane to improve its antifouling property. Tannic acid/ferric ion (TA/Fe) complexes were firstly coated as a precursor layer on the membrane surface via self-assembly. Afterwards, the tannic acid/diethylenetriamine (TA/DETA) hydrophilic functional layer was further coated, following Ag/polyvinylpyrrolidone (PVP) anti-bacterial layer was formed through the reducibility of TA to obtain TA/Fe-TA/DETA-Ag/PVP-modified membrane.

Agomirs upregulating carboxypeptidase E expression rescue hippocampal neurogenesis and memory deficits in Alzheimer's disease.

Background: Adult neurogenesis occurs in the subventricular zone (SVZ) and the subgranular zone of the dentate gyrus in the hippocampus. The neuronal stem cells in these two neurogenic niches respond differently to various physiological and pathological stimuli. Recently, we have found that the decrement of carboxypeptidase E (CPE) with aging impairs the maturation of brain-derived neurotrophic factor (BDNF) and neurogenesis in the SVZ.

Single-chain fluorescent integrators for mapping G-protein-coupled receptor agonists.

G protein-coupled receptors (GPCRs) transduce the effects of many neuromodulators including dopamine, serotonin, epinephrine, acetylcholine, and opioids. The localization of synthetic or endogenous GPCR agonists impacts their action on specific neuronal pathways. In this paper, we show a series of single-protein chain integrator sensors that are highly modular and could potentially be used to determine GPCR agonist localization across the brain.

Associations between brake and tire wear-related PM metal components, particulate oxidative stress potential, and autism spectrum disorder in Southern California.

Background: Air pollution is a global health concern, with fine particulate matter (PM) constituents posing potential risks to human health, including children's neurodevelopment. Here we investigated associations between exposure during pregnancy and infancy to specific traffic-related PM components with Autism Spectrum Disorder (ASD) diagnosis.

Methods: For exposure assessment, we estimated PM components related to traffic exposure (Barium [Ba] as a marker of brake dust and Zinc [Zn] as a tire wear marker, Black Carbon [BC]) and oxidative stress potential (OSP) markers (Hydroxyl Radical [OP] formation, Dithiothreitol activity [OP], reactive oxygen species [ROS]) modeled with land use regression with co-kriging based on an intensive air monitoring campaign.

Influence of multi-walled carbon nanotubes on the toxicity of ZnO nanoparticles in the intestinal histopathology, apoptosis, and microbial community of common carp.

In recent years, carbon nanotubes (CNTs) have gained tremendous attention due to their widespread application. Previous research indicated that carbon nanomaterials can affect the toxicity of some pollutants. In this study, we investigated the influence of multi-walled CNTs (MWCNTs) on the toxicity of ZnO nanoparticles (ZnONPs) in the intestine of common carp (Cyprinus carpio).

Fine Particulate Matter Metal Composition, Oxidative Potential, and Adverse Birth Outcomes in Los Angeles.

Background: Although many studies have linked prenatal exposure to to adverse birth outcomes, little is known about the effects of exposure to specific constituents of or mechanisms that contribute to these outcomes.

Objectives: Our objective was to investigate effects of oxidative potential and metal components from non-exhaust traffic emissions, such as brake and tire wear, on the risk of preterm birth (PTB) and term low birth weight (TLBW).

Methods: For a birth cohort of 285,614 singletons born in Los Angeles County, California, in the period 2017-2019, we estimated speciated exposures modeled from land use regression with cokriging, including brake and tire wear related metals (barium and zinc), black carbon, and three markers of oxidative potential (OP), including modeled reactive oxygen species based on measured iron and copper (ROS), OH formation (), and dithiothreitol (DTT) loss ().

Polydopamine modified cerium-based MOFs/ chitosan aerogel beads for the efficient phosphate removal.

The metal organic frameworks (MOFs) are considered as the effective adsorbents for phosphate removal, while their ultrafine powders limit their practical application. In this study, we fabricate two chitosan (CS) gel beads added with different cerium-based MOFs and coated with PDA for phosphate adsorption. The MOFs doped in beads are CM1 and CM2, in which the Ce(III)/Ce(IV) ratio is 0.

Chemotherapeutic Drugs Endow Gastric Cancer Mesenchymal Stem Cells with Stronger Tumor-Promoting Ability.

Gastric cancer (GC) is one of the most aggressive tumors and has a poor prognosis. It has been demonstrated that gastric cancer mesenchymal stem cells (GC-MSCs) can promote the progression, metastasis, and chemoresistance of GC through various mechanisms, but the effect of GC-MSCs on GC during chemotherapy is still unknown. In this study, flow cytometry, CCK8 assay, migration assay, colony formation assay, and western blot were conducted.

Intravenous nanocrystals: fabrication, solidification, in vivo fate, and applications for cancer therapy.

Introduction: Intravenous nanocrystals (INCs) have shown intrinsic advantages in antitumor applications, particularly their properties of high drug loading, low toxicity, and controllable size. Therefore, it has a very bright application prospect as a drug delivery system.

Areas Covered: The ideal formulation design principles, fabrication, solidification, in vivo fate of INCs, the applications in drug delivery system (DDS) and the novel applications are covered in this review.

Interaction of Cerium Oxide Nanoparticles and Ionic Cerium with Duckweed ( L.): Uptake, Distribution, and Phytotoxicity.

As one of the most widely used nanomaterials, CeO nanoparticles (NPs) might be released into the aquatic environment. In this paper, the interaction of CeO NPs and Ce ions (0~10 mg/L) with duckweed ( L.) was investigated.

A bifunctional anti-PCSK9 scFv/Exendin-4 fusion protein exhibits enhanced lipid-lowering effects via targeting multiple signaling pathways in HFD-fed mice.

Fusion protein which encompasses more than one functional component, has become one of the most important representatives of macromolecular drugs for disease treatment since that monotherapy itself might not be effective enough to eradicate the disease. In this study, we sought to construct a bifunctional antibody fusion protein by fusing anti-PCSK9 scFv with Exendin-4 for simultaneously lowering both LDL-C and TG. Firstly, three Ex4-anti-PCSK9 scFv fusion proteins were constructed by genetically connecting the C-terminal of Exendin-4 to the N-terminal of anti-PCSK9 scFv through various flexible linker peptides (G4S)n (n = 2, 3, 4).

Fluorogenic chemically induced dimerization.

A new chemically induced dimerization (CID) pair exhibits fluorescence upon dimerization for the first time. Moreover, the CID pair is small in size and offers easily reversible dimerization that can be repeated multiple times.

Robust quantification of the burst of OH radicals generated by ambient particles in nascent cloud droplets using a direct-to-reagent approach.

Reactive oxygen species (ROS) play a central role in chemistry in cloud water, as well as in other aqueous phases such as lung fluid and in wastewater treatment. Recently, work simulating nascent cloud droplets showed that aerosol particles produce a large burst of OH radicals when they first take up water. This activity stops abruptly, within two minutes.