Identification of Potential Diagnostic Biomarkers of Carotid Atherosclerosis in Obese Populations.

Objective: This study aimed to investigate the potential mechanisms and biomarkers between Obesity (OB) and carotid atherosclerosis (CAS).

Methods: The GSE12828, GSE125771, GSE43292, and GSE100927 datasets were combined and normalized to obtain CAS-related differentially expressed genes (DEGs), and OB-related DEGs were obtained from the GSE151839 dataset and the GeneCards database. Unsupervised cluster analysis was conducted on CAS samples based on the DEGs of CAS and OB.

A highly sensitive and fast-response fluorescence nanoprobe for in vivo imaging of hypochlorous acid.

Fluorescent probes for in vivo hypochlorous acid (HClO) imaging often face challenges of low selectivity and high cytotoxicity, largely due to poor analyte recognition and water-insoluble aromatic skeletons. To address this, we synthesized fluorescein hydrazide by introducing a spiro-lactam unit into fluorescein, which offers high emission intensity and molar absorption. The five-membered heterocycle in fluorescein hydrazide is selectively disrupted by HClO, enhancing the conjugated system and electron delocalization of the fluorophore, resulting in highly sensitive fluorescence detection of HClO.

Correlation of Sensitization with Mucus Plugging in COPD.

Background: Both sensitization and mucus plugs are associated with poor clinical outcomes in COPD. However, little is known about the association between hypersensitivity and mucus plugging in patients with COPD.

Methods: We retrospectively enrolled COPD patients who had visited Peking University Third Hospital and received measurement of the specific IgE ( sIgE) from Oct 1, 2018 to Sep 30, 2023.

The Association of Blood Eosinophils and Neutrophils Expressing Eosinophilic Surface Markers with the Severity and Outcome of COVID-19.

(1) Background: The implication of type 2 (T2) inflammatory response in COVID-19 remains controversial. This study aimed to evaluate the association of eosinophils, neutrophils expressing eosinophilic surface markers and T2 cytokines with the severity and outcome of COVID-19. (2) Methods: Patients who were admitted to hospital due to COVID-19 from 18 December 2022 to 31 January 2023 were enrolled.

Total parietal peritonectomy and multivisceral resection for extensive cytoreductive surgery in pseudomyxoma peritonei: En bloc "Rolled-up carpet" technique and perioperative and oncologic outcomes.

Background: Patients diagnosed with pseudomyxoma peritonei (PMP) of appendiceal origin typically present with high tumor burden and require extensive cytoreductive surgery (CRS) to achieve optimal cytoreduction. This study describes an en bloc "rolled-up carpet" surgical technique for total parietal peritonectomy and multivisceral resection while also analyzing the perioperative and tumor outcomes of this technique.

Methods: The study reviewed the data of 7 patients underwent en bloc "rolled-up carpet" extensive CRS between August 2020 and April 2023.

A predictive model for the classification of emergency intensive care unit patients with systemic inflammatory response syndrome based on a similarity network fusion algorithm.

Background: Intensive care unit-acquired weakness (ICU-AW) is a prevalent and severe neuromuscular complication in critically ill patients. It is a consequence of critical illness and is characterized by systemic inflammatory response syndrome (SIRS)-induced metabolic stress and multiple organ dysfunctions. Moreover, ICU-AW is one of the most important factors affecting the prognosis of patients with SIRS, Electrophysiological examination is an effective method for early identification and monitoring of the course of the disease and is essential for accurate diagnosis of critical illness neuromyopathy (CINM).

Feasibility and value of modular splenic hilar lymphadenectomy technique in laparoscopic total gastrectomy: a retrospective-controlled research.

Background: This study aims to investigate the feasibility and value of modular splenic hilar lymphadenectomy (MSHL) in LTG for advanced PGC located at the greater curvature.

Study Design: A retrospective-controlled research included 54 patients diagnosed with advanced PGC located at the greater curvature who underwent LTG combined with spleen-preserving hilar lymphadenectomy between January 2020 and December 2022 at the same treatment center. A total of 20 patients underwent classic splenic hilar lymphadenectomy (CSHL) using a medial approach (classic group), while 34 patients underwent MSHL (modular group).

Impacts of chloride ions on the electrochemical decomplexation and degradation of Cr(III)-EDTA: Reaction mechanisms of HO and RCS.

The removal of Cr(III)-organic complexes, encompassing both decomplexation and ligand degradation, presents significant challenges in industrial wastewater treatment. As one of the most common anions in wastewater, Cl significantly improves the efficiency of electrochemically removing Cr(III)-organic complexes through generated reactive chlorine species (RCS). In the electrochemical chlorine (EC/Cl) process, extensive experimentation revealed that ClO plays a dominant role in the degradation of Cr(III)-EDTA, surpassing the effects of free chlorine, direct electrooxidation, HO, and other RCS.

City-level synergy and co-benefits of mitigating CO emissions and air pollution in China.

Synergistic control of carbon emissions and pollutant concentrations can efficiently tackle climate change and air pollution. The synergistic performance and co-benefits yielded by controlling these factors are urgent and critical issues in China. Accordingly, a comprehensive indicator for assessing synergistic performance is pioneered, and co-benefits of mitigating CO and PM in Chinese cities are evaluated.

The role of CBL family ubiquitin ligases in cancer progression and therapeutic strategies.

The CBL (Casitas B-lineage lymphoma) family, as a class of ubiquitin ligases, can regulate signal transduction and activate receptor tyrosine kinases through various tyrosine kinase-dependent pathways. There are three members of the family: c-CBL, CBL-b, and CBL-c. Numerous studies have demonstrated the important role of CBL in various cellular pathways, particularly those involved in the occurrence and progression of cancer, hematopoietic development, and regulation of T cell receptors.

Innovative pancreas-guided technique for splenic flexure mobilization in laparoscopic left hemicolectomy.

Objective: Splenic flexure mobilization (SFM) is a major challenge in laparoscopic left hemicolectomy. This study aims to assess the safety and effectiveness of the pancreas-guided SFM technique during laparoscopic left hemicolectomy.

Methods: From January 2018 to December 2023, 352 patients with left-sided colon cancer underwent laparoscopic left hemicolectomy.

A Principal Component Regression-Based Electrophysiological Study of Patients with Severe Infections.

Objective: Severe infections can lead to neuromyopathy in critically ill patients, resulting in limb weakness and difficulty in weaning from a ventilator. This study aims to assess the electrophysiological test results in patients with severe infection and their correlation with severity scores (APACHE II and SOFA).

Methods: Thirty-one patients with severe infection in the EICU were prospectively studied.

Tailoring the Molecular Planarity of Perylene Diimide-Based Third Component toward Efficient Ternary Organic Solar Cells.

Incorporating a third component into binary organic solar cells (b-OSCs) has provided a potential platform to boost power conversion efficiency (PCEs). However, gaining control over the non-equilibrium blend morphology via the molecular design of the perylene diimide (PDI)-based third component toward efficient ternary organic solar cells (t-OSCs) still remains challenging. Herein, two novel PDI derivatives are developed with tailored molecular planarity, namely ufBTz-2PDI and fBTz-2PDI, as the third component for t-OSCs.

Elevated CD4 T Cell Senescence Associates with Impaired Immune Responsiveness in Severe COVID-19.

Aging is a critical risk factor for unfavorable clinical outcomes among COVID-19 patients and may impact vaccine efficacy. However, whether the senescence of T cells is associated with severe COVID-19 outcome in elderly individuals is unclear. Using flow cytometry, we analyzed the frequency of senescent T cells (Tsens) in peripheral blood from 100 hospitalized elderly COVID-19 patients and compared differences between those with mild/moderate and severe/critical illness.

Global trends and partial forecast of adverse effects of medical treatment from 1990 to 2019: an epidemiological analysis based on the global burden of disease study 2019.

Background: The possibility of adverse effects of medical treatment (AEMT) is increasing worldwide, but little is known about AEMT in China. This study analyzed the health burden of AEMT in China in recent years through the Global Burden of Disease Study (GBD) 2019 and compared it with the worldwide average level and those in different sociodemographic index (SDI) regions.

Methods: We calculated the age-standardized rate (ASR) of deaths, disability-adjusted life years (DALYs), years of life lost (YLLs), years lived with disability (YLDs), incidence and prevalence attributed to AEMT in China, worldwide and countries with different sociodemographic indices during 1990-2019 using the latest data and methods from the GBD 2019.

Symptoms and medical resource utilization of patients with bronchiectasis after SARS-CoV-2 infection.

Background: The impact of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on patients with bronchiectasis in terms of symptoms, self-management and medical resource utilization was unknown.

Objective: To describe the impact of infection by SARS-CoV-2 on fluctuation of symptoms, self-management and medical resource utilization of patients with bronchiectasis during the pandemic of COVID-19.

Methods: This was a single-center cross-sectional questionnaire study performed in Peking University Third Hospital.

Modelling and Research on Intuitionistic Fuzzy Goal-Based Attack and Defence Game for Infrastructure Networks.

Network attack and defence games are gradually becoming a new approach through which to study the protection of infrastructure networks such as power grids and transportation networks. Uncertainty factors, such as the subjective decision preferences of attackers and defenders, are not considered in existing attack and defence game studies for infrastructure networks. In this paper, we introduce, respectively, the attacker's and defender's expectation value, rejection value, and hesitation degree of the target, as well as construct an intuitionistic fuzzy goal-based attack and defence game model for infrastructure networks that are based on the maximum connectivity slice size, which is a network performance index.

Advances in targeted therapy for pancreatic cancer.

Pancreatic cancer (PC) represents a group of malignant tumours originating from pancreatic duct epithelial cells and acinar cells, and the 5-year survival rate of PC patients is only approximately 12%. Molecular targeted drugs are specific drugs designed to target and block oncogenes, and they have become promising strategies for the treatment of PC. Compared to traditional chemotherapy drugs, molecular targeted drugs have greater targeting precision, and they have significant therapeutic effects and minimal side effects.

Improved Interlaminar Properties of Glass Fiber/Epoxy Laminates by the Synergic Modification of Soft and Rigid Particles.

Poor interlaminar fracture toughness has been a major issue in glass fiber-reinforced epoxy resin (GF/EP) laminate composites. In this paper, soft carboxy-terminated nitrile (CTBN) rubber particles and rigid nano-SiO are used to toughen the epoxy resin (EP) matrix to improve the interlayer properties of GF/EP laminate composites. The effects of adding two toughening agents on the mechanical and interlayer properties of GF/EP laminates were studied.

Association of blood total immunoglobulin E and eosinophils with radiological features of bronchiectasis.

Background: Our study aimed to investigate whether serum total IgE and blood eosinophils were associated with radiological features of bronchiectasis in a Chinese cohort.

Methods: We retrospectively enrolled bronchiectasis patients who visited Peking University Third Hospital from Jan 1, 2012 to Oct 7, 2021. The clinical, laboratory and chest CT characteristics were analyzed in association with serum total IgE level and blood eosinophil count.

The role of reactive phosphate species in the abatement of micropollutants by activated peroxymonosulfate in the treatment of phosphate-rich wastewater.

This study investigated the mechanisms of forming reactive species to degrade micropollutants through the activation of peroxymonosulfate (PMS) by phosphate, a prevalent ion in wastewater. Considering the density functional theory results, the formation of hydrogen bonds between phosphate and PMS molecules might be the crucial step in the overall reactions, which prefers producing OH and reactive phosphate species (RPS, namely HPO, HPO, and PO) to yielding SO. Besides, in the phosphate (5 mM)/PMS system at pH = 8, HPO was modeled to be the dominant radical with a steady-state concentration of 3.

Geometric-phase-based axicon lens for computational achromatic imaging.

Conventional optical imaging systems usually utilize several lenses within a precise assembly to eliminate chromatic aberration, which increases the difficulty of system integration. In recent years, with the rapid development of metasurfaces and liquid crystals (LCs), planar optical elements provide feasible solutions to realize flexible light manipulation and lightweight systems. However, there also exists chromatic aberration, which can be corrected but at the cost of a complex device design.